lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	474
Symbol	ATOH1
Synonymous	ATH1\|HATH1\|MATH-1\|bHLHa14
Full name	atonal homolog 1 (Drosophila)
Gene description	class A basic helix-loop-helix protein 14\|helix-loop-helix protein hATH-1\|protein atonal homolog 1
Cytoband	4q22
Gene type	protein-coding
Synonymous	MIM:601461; HGNC:HGNC:797; HPRD:03270

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.677C>T; p.P226L; 4:93829603-93829603	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.95C>A; p.P32Q; 4:93829021-93829021	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.846G>A; p.A282A; 4:93829772-93829772	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.522G>T; p.G174G; 4:93829448-93829448	liver	carcinoma	Substitution - coding silent
c.522G>T; p.G174G; 4:93829448-93829448	liver	carcinoma	Substitution - coding silent
c.374G>A; p.R125Q; 4:93829300-93829300	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.281C>A; p.A94E; 4:93829207-93829207	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.102G>A; p.P34P; 4:93829028-93829028	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.505C>G; p.R169G; 4:93829431-93829431	kidney	carcinoma; renal_cell_carcinoma	Substitution - Missense
c.304_305insG; p.E104fs*96; 4:93829230-93829231	skin; head_neck	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.182C>A; p.P61Q; 4:93829108-93829108	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.931T>G; p.L311V; 4:93829857-93829857	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.474G>A; p.K158K; 4:93829400-93829400	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.768T>G; p.A256A; 4:93829694-93829694	stomach	adenocarcinoma	Substitution - coding silent
c.832G>A; p.A278T; 4:93829758-93829758	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.165C>G; p.L55L; 4:93829091-93829091	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.527A>G; p.N176S; 4:93829453-93829453	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.992C>T; p.S331L; 4:93829918-93829918	breast	carcinoma	Substitution - Missense
c.173G>T; p.S58I; 4:93829099-93829099	urinary_tract; bladder	carcinoma	Substitution - Missense
c.962A>G; p.Q321R; 4:93829888-93829888	liver	carcinoma	Substitution - Missense
c.962A>G; p.Q321R; 4:93829888-93829888	liver	carcinoma	Substitution - Missense
c.1057G>A; p.A353T; 4:93829983-93829983	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1018G>A; p.E340K; 4:93829944-93829944	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1017G>A; p.G339G; 4:93829943-93829943	skin	malignant_melanoma	Substitution - coding silent
c.739G>A; p.G247S; 4:93829665-93829665	liver	carcinoma	Substitution - Missense
c.739G>A; p.G247S; 4:93829665-93829665	liver	carcinoma	Substitution - Missense
c.916A>G; p.M306V; 4:93829842-93829842	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.500G>A; p.R167K; 4:93829426-93829426	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.892G>A; p.E298K; 4:93829818-93829818	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.5C>T; p.S2F; 4:93828931-93828931	breast	carcinoma	Substitution - Missense
c.29G>T; p.W10L; 4:93828955-93828955	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.82C>G; p.L28V; 4:93829008-93829008	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.860T>A; p.V287E; 4:93829786-93829786	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.531C>T; p.H177H; 4:93829457-93829457	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - coding silent
c.305delG; p.E104fs*3; 4:93829231-93829231	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.305delG; p.E104fs*3; 4:93829231-93829231	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.766G>A; p.A256T; 4:93829692-93829692	breast	carcinoma	Substitution - Missense
c.54C>T; p.D18D; 4:93828980-93828980	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.828C>A; p.F276L; 4:93829754-93829754	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.178G>A; p.D60N; 4:93829104-93829104	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.967G>A; p.V323M; 4:93829893-93829893	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.967G>A; p.V323M; 4:93829893-93829893	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.229G>A; p.A77T; 4:93829155-93829155	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.736G>T; p.G246W; 4:93829662-93829662	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.597G>A; p.E199E; 4:93829523-93829523	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.333C>T; p.G111G; 4:93829259-93829259	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - coding silent
c.1025delC; p.H344fs*>11; 4:93829951-93829951	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.104C>A; p.P35Q; 4:93829030-93829030	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1025delC; p.H344fs*>11; 4:93829951-93829951	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.599C>T; p.T200I; 4:93829525-93829525	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.516G>A; p.M172I; 4:93829442-93829442	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.720C>A; p.T240T; 4:93829646-93829646	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.783A>G; p.G261G; 4:93829709-93829709	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.783A>G; p.G261G; 4:93829709-93829709	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.783A>G; p.G261G; 4:93829709-93829709	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.252C>T; p.S84S; 4:93829178-93829178	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.973G>T; p.E325*; 4:93829899-93829899	liver	carcinoma	Substitution - Nonsense
c.373C>T; p.R125W; 4:93829299-93829299	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.305G>C; p.R102P; 4:93829231-93829231	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.891C>G; p.F297L; 4:93829817-93829817	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.579G>T; p.K193N; 4:93829505-93829505	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.579G>T; p.K193N; 4:93829505-93829505	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.571A>C; p.N191H; 4:93829497-93829497	breast	carcinoma	Substitution - Missense
c.376G>A; p.E126K; 4:93829302-93829302	skin	malignant_melanoma	Substitution - Missense
c.390G>C; p.K130N; 4:93829316-93829316	skin	malignant_melanoma	Substitution - Missense
c.407T>C; p.V136A; 4:93829333-93829333	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.259C>T; p.L87L; 4:93829185-93829185	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.756C>T; p.T252T; 4:93829682-93829682	skin	malignant_melanoma	Substitution - coding silent
c.575delA; p.D192fs*111; 4:93829501-93829501	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.750C>A; p.N250K; 4:93829676-93829676	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.884C>T; p.S295L; 4:93829810-93829810	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.568A>G; p.N190D; 4:93829494-93829494	prostate	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation