Cancer metastasis database

Annotation category 5

Gene information

Gene ID 47
Symbol

ACLY

Synonymous

ACL|ATPCL|CLATP

Full name

ATP citrate lyase

Gene description

ATP citrate synthase|ATP-citrate (pro-S-)-lyase|ATP-citrate synthase|citrate cleavage enzyme

Cytoband

17q21.2

Gene type

protein-coding

Synonymous

MIM:108728; HGNC:HGNC:115; Ensembl:ENSG00000131473; HPRD:00155; Vega:OTTHUMG00000133507

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.3150A>G; p.E1050E; 17:41868770-41868770

kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - coding silent

c.394G>A; p.V132I; 17:41909652-41909652

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2700C>T; p.H900H; 17:41872125-41872125

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.138C>A; p.D46E; 17:41913736-41913736

prostateadenomaSubstitution - Missense

c.2912T>C; p.M971T; 17:41871714-41871714

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2743C>T; p.R915*; 17:41872082-41872082

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.2548C>T; p.Q850*; 17:41873905-41873905

central_nervous_system; braingliomaSubstitution - Nonsense

c.3134G>T; p.R1045L; 17:41869043-41869043

prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.3253C>T; p.R1085C; 17:41867863-41867863

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1816A>T; p.T606S; 17:41887658-41887658

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1184-8C>A; p.?; 17:41898793-41898793

livercarcinomaUnknown

c.1184-8C>A; p.?; 17:41898793-41898793

livercarcinomaUnknown

c.2860A>G; p.I954V; 17:41871766-41871766

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.2615T>C; p.V872A; 17:41873838-41873838

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1071C>T; p.I357I; 17:41901808-41901808

upper_aerodigestive_tract; larynxcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1689T>C; p.H563H; 17:41892360-41892360

thyroidother; neoplasmSubstitution - coding silent

c.2494G>C; p.G832R; 17:41873959-41873959

breastcarcinomaSubstitution - Missense

c.559G>A; p.G187S; 17:41909046-41909046

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1927C>T; p.L643L; 17:41886257-41886257

skinmalignant_melanomaSubstitution - coding silent

c.2793C>T; p.I931I; 17:41872032-41872032

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.245A>G; p.K82R; 17:41912457-41912457

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.274G>A; p.E92K; 17:41912428-41912428

urinary_tract; bladdercarcinomaSubstitution - Missense

c.2637G>A; p.Q879Q; 17:41873816-41873816

lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1120_1125delACAATC; p.T374_I375delTI; 17:41901754-41901759

livercarcinoma; hepatocellular_carcinomaDeletion - In frame

c.1005C>A; p.G335G; 17:41904789-41904789

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.1148A>G; p.N383S; 17:41901731-41901731

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1148A>G; p.N383S; 17:41901731-41901731

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.859G>A; p.V287M; 17:41906535-41906535

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2078C>T; p.P693L; 17:41884269-41884269

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1285C>A; p.P429T; 17:41898684-41898684

breastcarcinomaSubstitution - Missense

c.1920T>G; p.G640G; 17:41886264-41886264

breastcarcinomaSubstitution - coding silent

c.3066C>G; p.I1022M; 17:41869111-41869111

urinary_tract; bladdercarcinomaSubstitution - Missense

c.2637G>C; p.Q879H; 17:41873816-41873816

urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.1838C>T; p.A613V; 17:41887636-41887636

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1422G>A; p.M474I; 17:41897756-41897756

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1422G>A; p.M474I; 17:41897756-41897756

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.2019C>T; p.I673I; 17:41886165-41886165

skinmalignant_melanomaSubstitution - coding silent

c.2996C>T; p.P999L; 17:41869529-41869529

breastcarcinomaSubstitution - Missense

c.976C>A; p.L326I; 17:41905549-41905549

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1394C>T; p.A465V; 17:41897784-41897784

oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1376C>T; p.S459F; 17:41897802-41897802

skinmalignant_melanomaSubstitution - Missense

c.3166G>A; p.A1056T; 17:41868754-41868754

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.2956C>T; p.R986*; 17:41869569-41869569

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.2956C>T; p.R986*; 17:41869569-41869569

large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.867C>T; p.S289S; 17:41905658-41905658

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.747G>A; p.E249E; 17:41907442-41907442

oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.604A>T; p.I202F; 17:41909001-41909001

breastcarcinomaSubstitution - Missense

c.343C>A; p.Q115K; 17:41910224-41910224

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.3239A>T; p.K1080M; 17:41867877-41867877

oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.1803C>A; p.I601I; 17:41887671-41887671

oesophaguscarcinomaSubstitution - coding silent

c.3275C>G; p.S1092*; 17:41867841-41867841

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.2751G>A; p.G917G; 17:41872074-41872074

urinary_tract; bladdercarcinomaSubstitution - coding silent

c.413G>A; p.G138E; 17:41909633-41909633

oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.541C>T; p.L181L; 17:41909064-41909064

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.965C>A; p.T322N; 17:41905560-41905560

large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.1592A>C; p.Y531S; 17:41893042-41893042

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.1048G>T; p.V350L; 17:41904746-41904746

livercarcinomaSubstitution - Missense

c.932C>T; p.P311L; 17:41905593-41905593

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1174G>T; p.G392*; 17:41901705-41901705

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1123A>G; p.I375V; 17:41901756-41901756

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2238G>A; p.G746G; 17:41883149-41883149

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.2391C>T; p.I797I; 17:41878799-41878799

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.3205T>C; p.F1069L; 17:41868715-41868715

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.979A>G; p.M327V; 17:41905546-41905546

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.3191G>A; p.G1064E; 17:41868729-41868729

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1293G>A; p.A431A; 17:41898676-41898676

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1958G>A; p.R653H; 17:41886226-41886226

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.441C>T; p.A147A; 17:41909605-41909605

central_nervous_system; braingliomaSubstitution - coding silent

c.3261G>A; p.P1087P; 17:41867855-41867855

large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.742C>T; p.P248S; 17:41907447-41907447

skinmalignant_melanomaSubstitution - Missense

c.3030A>T; p.V1010V; 17:41869495-41869495

urinary_tract; bladdercarcinomaSubstitution - coding silent

c.747+6G>T; p.?; 17:41907436-41907436

oesophaguscarcinoma; adenocarcinomaUnknown

c.2186G>T; p.R729L; 17:41883201-41883201

skinmalignant_melanomaSubstitution - Missense

c.2072+1G>A; p.?; 17:41886111-41886111

breastcarcinomaUnknown

c.1804C>T; p.P602S; 17:41887670-41887670

skinmalignant_melanomaSubstitution - Missense

c.730C>T; p.R244W; 17:41907459-41907459

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1372G>T; p.E458*; 17:41897806-41897806

kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Nonsense

c.1384G>A; p.D462N; 17:41897794-41897794

cervixcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2999C>T; p.A1000V; 17:41869526-41869526

livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.2998G>T; p.A1000S; 17:41869527-41869527

livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.2999C>T; p.A1000V; 17:41869526-41869526

livercarcinomaSubstitution - Missense

c.2998G>T; p.A1000S; 17:41869527-41869527

livercarcinomaSubstitution - Missense

c.1945T>A; p.S649T; 17:41886239-41886239

skinmalignant_melanomaSubstitution - Missense

c.2954T>C; p.M985T; 17:41869571-41869571

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.29C>T; p.T10M; 17:41913845-41913845

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.29C>T; p.T10M; 17:41913845-41913845

oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.348T>C; p.A116A; 17:41909698-41909698

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.2487-7C>T; p.?; 17:41873973-41873973

kidneycarcinoma; clear_cell_renal_cell_carcinomaUnknown

c.3216C>T; p.H1072H; 17:41867900-41867900

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.716C>T; p.P239L; 17:41907473-41907473

skinmalignant_melanomaSubstitution - Missense

c.255G>A; p.L85L; 17:41912447-41912447

urinary_tract; bladdercarcinomaSubstitution - coding silent

c.150G>A; p.L50L; 17:41913724-41913724

urinary_tract; bladdercarcinomaSubstitution - coding silent

c.2543G>A; p.R848Q; 17:41873910-41873910

breastcarcinomaSubstitution - Missense

c.1268C>T; p.P423L; 17:41898701-41898701

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.2410C>A; p.L804I; 17:41878180-41878180

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1848G>A; p.K616K; 17:41887626-41887626

large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.1561C>T; p.R521*; 17:41893073-41893073

stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1416_1417insC; p.A473fs*44; 17:41897761-41897762

central_nervous_system; brainglioma; astrocytoma_Grade_IVInsertion - Frameshift

c.723C>T; p.P241P; 17:41907466-41907466

lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1054G>A; p.A352T; 17:41904740-41904740

livercarcinomaSubstitution - Missense

c.1054G>A; p.A352T; 17:41904740-41904740

livercarcinomaSubstitution - Missense

c.512T>A; p.V171D; 17:41909534-41909534

stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.815A>T; p.K272I; 17:41906579-41906579

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.726C>T; p.F242F; 17:41907463-41907463

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.726C>T; p.F242F; 17:41907463-41907463

large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.3296T>C; p.M1099T; 17:41867820-41867820

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2221G>A; p.V741I; 17:41883166-41883166

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2750G>C; p.G917A; 17:41872075-41872075

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1989C>T; p.S663S; 17:41886195-41886195

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1781T>G; p.I594S; 17:41887693-41887693

skinmalignant_melanomaSubstitution - Missense

c.2183G>A; p.C728Y; 17:41883204-41883204

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2240C>T; p.T747M; 17:41883147-41883147

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.397C>T; p.L133L; 17:41909649-41909649

skinmalignant_melanomaSubstitution - coding silent

c.1811_1812CC>TT; p.A604V; 17:41887662-41887663

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.3223G>T; p.D1075Y; 17:41867893-41867893

thyroidcarcinomaSubstitution - Missense

c.3287C>T; p.P1096L; 17:41867829-41867829

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1008G>A; p.K336K; 17:41904786-41904786

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.2079G>A; p.P693P; 17:41884268-41884268

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.2567G>C; p.G856A; 17:41873886-41873886

breastcarcinomaSubstitution - Missense

c.1084C>T; p.R362*; 17:41901795-41901795

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.1273C>T; p.P425S; 17:41898696-41898696

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.2623C>T; p.L875F; 17:41873830-41873830

skinmalignant_melanomaSubstitution - Missense

c.2610C>T; p.G870G; 17:41873843-41873843

oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - coding silent

c.2701G>A; p.G901R; 17:41872124-41872124

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1364C>A; p.S455Y; 17:41897814-41897814

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1033G>A; p.A345T; 17:41904761-41904761

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2091C>G; p.F697L; 17:41884256-41884256

central_nervous_system; braingliomaSubstitution - Missense

c.3048G>A; p.S1016S; 17:41869477-41869477

endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.20C>T; p.S7L; 17:41913854-41913854

skinmalignant_melanomaSubstitution - Missense

c.1524C>T; p.A508A; 17:41893110-41893110

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.537-2A>C; p.?; 17:41909070-41909070

central_nervous_system; brainglioma; astrocytoma_Grade_IVUnknown

c.3143C>G; p.A1048G; 17:41868777-41868777

ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.2155-1G>T; p.?; 17:41883233-41883233

urinary_tract; bladdercarcinomaUnknown

c.3125C>T; p.S1042F; 17:41869052-41869052

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1A>T; p.M1L; 17:41913873-41913873

ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.891T>C; p.G297G; 17:41905634-41905634

stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.54C>T; p.F18F; 17:41913820-41913820

upper_aerodigestive_tract; mouthcarcinomaSubstitution - coding silent

c.54C>T; p.F18F; 17:41913820-41913820

upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.54C>T; p.F18F; 17:41913820-41913820

skinmalignant_melanomaSubstitution - coding silent

c.54C>T; p.F18F; 17:41913820-41913820

urinary_tract; bladdercarcinomaSubstitution - coding silent

c.1602-2A>G; p.?; 17:41892449-41892449

stomachcarcinoma; diffuse_adenocarcinomaUnknown

c.485C>T; p.P162L; 17:41909561-41909561

skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.980T>C; p.M327T; 17:41905545-41905545

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2778G>T; p.S926S; 17:41872047-41872047

oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.196C>T; p.R66C; 17:41912506-41912506

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.129G>C; p.L43F; 17:41913745-41913745

pancreascarcinoid-endocrine_tumourSubstitution - Missense

c.780T>G; p.S260R; 17:41906614-41906614

breastcarcinomaSubstitution - Missense

c.129G>C; p.L43F; 17:41913745-41913745

ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.2350G>T; p.V784L; 17:41878840-41878840

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2797_2798insG; p.D933fs*16; 17:41871828-41871829

large_intestinecarcinoma; adenocarcinomaInsertion - Frameshift

c.2350G>T; p.V784L; 17:41878840-41878840

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.2350G>T; p.V784L; 17:41878840-41878840

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.688A>C; p.K230Q; 17:41907501-41907501

lungcarcinoma; adenocarcinomaSubstitution - Missense

c.2549A>T; p.Q850L; 17:41873904-41873904

lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.3098T>G; p.F1033C; 17:41869079-41869079

endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.2799T>C; p.D933D; 17:41871827-41871827

stomachadenocarcinomaSubstitution - coding silent

c.443A>C; p.K148T; 17:41909603-41909603

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.16A>G; p.I6V; 17:41913858-41913858

lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1801A>G; p.I601V; 17:41887673-41887673

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.22G>A; p.E8K; 17:41913852-41913852

urinary_tract; bladdercarcinomaSubstitution - Missense

c.2622C>T; p.G874G; 17:41873831-41873831

livercarcinomaSubstitution - coding silent

c.1990G>A; p.G664R; 17:41886194-41886194

large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1990G>A; p.G664R; 17:41886194-41886194

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.3012C>T; p.L1004L; 17:41869513-41869513

skinmalignant_melanomaSubstitution - coding silent

c.2051G>A; p.G684D; 17:41886133-41886133

breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.2979C>T; p.Y993Y; 17:41869546-41869546

large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.1573T>G; p.S525A; 17:41893061-41893061

central_nervous_system; braingliomaSubstitution - Missense

c.2236G>A; p.G746R; 17:41883151-41883151

stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.654G>A; p.A218A; 17:41907535-41907535

lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1165C>T; p.R389W; 17:41901714-41901714

oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.2499G>C; p.L833F; 17:41873954-41873954

urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.60T>C; p.C20C; 17:41913814-41913814

stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1896G>A; p.G632G; 17:41886288-41886288

lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.708C>T; p.I236I; 17:41907481-41907481

skinmalignant_melanomaSubstitution - coding silent

c.573C>G; p.F191L; 17:41909032-41909032

skinmalignant_melanomaSubstitution - Missense

c.1752G>A; p.E584E; 17:41892297-41892297

large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.2643-7A>G; p.?; 17:41872189-41872189

livercarcinomaUnknown

c.2643-7A>G; p.?; 17:41872189-41872189

livercarcinomaUnknown

c.1641G>T; p.E547D; 17:41892408-41892408

kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.1264C>T; p.R422W; 17:41898705-41898705

stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.517G>A; p.A173T; 17:41909529-41909529

large_intestinecarcinoma; adenocarcinomaSubstitution - Missense