lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4324
Symbol	MMP15
Synonymous	MT2-MMP\|MTMMP2\|SMCP-2
Full name	matrix metallopeptidase 15 (membrane-inserted)
Gene description	MMP-15\|MT-MMP 2\|MT2MMP\|matrix metalloproteinase 15 (membrane-inserted)\|matrix metalloproteinase-15\|membrane-type matrix metalloproteinase 2\|membrane-type-2 matrix metalloproteinase
Cytoband	16q13
Gene type	protein-coding
Synonymous	MIM:602261; HGNC:HGNC:7161; Ensembl:ENSG00000102996; HPRD:03775; Vega:OTTHUMG00000133466

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.505C>T; p.R169C; 16:58039939-58039939	skin	malignant_melanoma	Substitution - Missense
c.505C>T; p.R169C; 16:58039939-58039939	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.527C>T; p.P176L; 16:58039961-58039961	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.225C>T; p.S75S; 16:58037534-58037534	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1186C>T; p.R396W; 16:58042252-58042252	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1169G>T; p.R390L; 16:58042235-58042235	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.226G>T; p.A76S; 16:58037535-58037535	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.240C>A; p.A80A; 16:58037549-58037549	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.430C>T; p.L144L; 16:58038384-58038384	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.719C>T; p.P240L; 16:58040153-58040153	skin	malignant_melanoma	Substitution - Missense
c.415T>C; p.W139R; 16:58038369-58038369	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.508G>T; p.V170L; 16:58039942-58039942	lung	carcinoma; mucoepidermoid_carcinoma	Substitution - Missense
c.876C>T; p.P292P; 16:58040664-58040664	skin	malignant_melanoma	Substitution - coding silent
c.574C>T; p.Q192*; 16:58040008-58040008	skin	malignant_melanoma	Substitution - Nonsense
c.359G>A; p.R120Q; 16:58038313-58038313	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1225G>A; p.G409R; 16:58042291-58042291	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1052G>C; p.G351A; 16:58041758-58041758	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.384T>G; p.R128R; 16:58038338-58038338	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.1141C>T; p.R381C; 16:58041847-58041847	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.587A>T; p.D196V; 16:58040021-58040021	breast	carcinoma	Substitution - Missense
c.399C>T; p.A133A; 16:58038353-58038353	skin	malignant_melanoma	Substitution - coding silent
c.1169G>A; p.R390H; 16:58042235-58042235	breast	carcinoma	Substitution - Missense
c.1851G>A; p.M617I; 16:58045287-58045287	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1869G>T; p.T623T; 16:58045305-58045305	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.379C>T; p.R127W; 16:58038333-58038333	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1678C>T; p.Q560*; 16:58045114-58045114	skin	malignant_melanoma	Substitution - Nonsense
c.830T>C; p.M277T; 16:58040618-58040618	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1161C>T; p.F387F; 16:58041867-58041867	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1834C>T; p.R612C; 16:58045270-58045270	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1776C>T; p.G592G; 16:58045212-58045212	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.781C>T; p.L261L; 16:58040569-58040569	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.221G>A; p.R74H; 16:58037530-58037530	meninges	meningioma; secretory	Substitution - Missense
c.186C>A; p.Y62*; 16:58037495-58037495	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Nonsense
c.967C>T; p.R323W; 16:58041673-58041673	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.967C>T; p.R323W; 16:58041673-58041673	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.937A>C; p.T313P; 16:58041643-58041643	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.937A>C; p.T313P; 16:58041643-58041643	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.937A>C; p.T313P; 16:58041643-58041643	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.1267T>C; p.Y423H; 16:58042333-58042333	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1683G>C; p.E561D; 16:58045119-58045119	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1861G>A; p.A621T; 16:58045297-58045297	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1164+1G>A; p.?; 16:58041871-58041871	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1420C>T; p.P474S; 16:58043326-58043326	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1081C>T; p.R361W; 16:58041787-58041787	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.968G>T; p.R323L; 16:58041674-58041674	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1052G>A; p.G351D; 16:58041758-58041758	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.199_200delAG; p.S67fs*80; 16:58037508-58037509	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.199_200delAG; p.S67fs*80; 16:58037508-58037509	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.1201C>G; p.L401V; 16:58042267-58042267	prostate	carcinoma	Substitution - Missense
c.1463G>A; p.R488H; 16:58043520-58043520	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.877G>A; p.E293K; 16:58040665-58040665	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.507C>T; p.R169R; 16:58039941-58039941	breast	carcinoma	Substitution - coding silent
c.509T>C; p.V170A; 16:58039943-58039943	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.351C>T; p.F117F; 16:58038305-58038305	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1787A>G; p.D596G; 16:58045223-58045223	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1470C>T; p.N490N; 16:58043527-58043527	breast	carcinoma	Substitution - coding silent
c.479C>T; p.S160L; 16:58039913-58039913	skin	malignant_melanoma	Substitution - Missense
c.382C>T; p.R128C; 16:58038336-58038336	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.631C>T; p.P211S; 16:58040065-58040065	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.649G>A; p.G217S; 16:58040083-58040083	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1126A>G; p.T376A; 16:58041832-58041832	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.888C>T; p.L296L; 16:58040676-58040676	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1209C>G; p.N403K; 16:58042275-58042275	breast	carcinoma	Substitution - Missense
c.295G>A; p.D99N; 16:58037604-58037604	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1143C>T; p.R381R; 16:58041849-58041849	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1384C>T; p.P462S; 16:58043290-58043290	skin	malignant_melanoma	Substitution - Missense
c.1825G>A; p.G609R; 16:58045261-58045261	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1825G>A; p.G609R; 16:58045261-58045261	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1281C>T; p.D427D; 16:58042347-58042347	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1281C>T; p.D427D; 16:58042347-58042347	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.596T>C; p.V199A; 16:58040030-58040030	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1514G>T; p.S505I; 16:58043571-58043571	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.890G>T; p.R297L; 16:58040678-58040678	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.664G>A; p.A222T; 16:58040098-58040098	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.749G>A; p.G250E; 16:58040537-58040537	breast	carcinoma	Substitution - Missense
c.1015C>A; p.P339T; 16:58041721-58041721	breast	carcinoma	Substitution - Missense
c.455C>T; p.T152M; 16:58039889-58039889	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.816C>A; p.N272K; 16:58040604-58040604	breast	carcinoma	Substitution - Missense
c.1584C>T; p.F528F; 16:58045020-58045020	skin	malignant_melanoma	Substitution - coding silent
c.238G>A; p.A80T; 16:58037547-58037547	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1113C>G; p.D371E; 16:58041819-58041819	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.506G>A; p.R169H; 16:58039940-58039940	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.506G>A; p.R169H; 16:58039940-58039940	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.359G>T; p.R120L; 16:58038313-58038313	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.380G>A; p.R127Q; 16:58038334-58038334	central_nervous_system; brain	glioma	Substitution - Missense
c.397G>A; p.A133T; 16:58038351-58038351	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1195C>T; p.R399C; 16:58042261-58042261	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.964C>T; p.R322W; 16:58041670-58041670	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1653C>T; p.S551S; 16:58045089-58045089	skin	malignant_melanoma	Substitution - coding silent
c.660C>A; p.A220A; 16:58040094-58040094	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.193C>G; p.Q65E; 16:58037502-58037502	urinary_tract; bladder	carcinoma	Substitution - Missense
c.376C>T; p.R126W; 16:58038330-58038330	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.786C>A; p.G262G; 16:58040574-58040574	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.644C>A; p.T215N; 16:58040078-58040078	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1611C>T; p.F537F; 16:58045047-58045047	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.965G>A; p.R322Q; 16:58041671-58041671	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1266C>A; p.A422A; 16:58042332-58042332	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.629C>T; p.S210L; 16:58040063-58040063	skin	malignant_melanoma	Substitution - Missense
c.1364C>A; p.T455N; 16:58043270-58043270	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1165-4_1165-3CC>TT; p.?; 16:58042227-58042228	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.734G>T; p.S245I; 16:58040168-58040168	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.495C>T; p.R165R; 16:58039929-58039929	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.572G>T; p.R191L; 16:58040006-58040006	skin	malignant_melanoma	Substitution - Missense
c.216C>T; p.T72T; 16:58037525-58037525	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.547C>T; p.P183S; 16:58039981-58039981	skin	malignant_melanoma	Substitution - Missense
c.396C>T; p.Y132Y; 16:58038350-58038350	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1617T>C; p.N539N; 16:58045053-58045053	pancreas	carcinoma	Substitution - coding silent
c.298G>A; p.E100K; 16:58037607-58037607	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.700C>G; p.H234D; 16:58040134-58040134	liver	carcinoma	Substitution - Missense
c.700C>G; p.H234D; 16:58040134-58040134	liver	carcinoma	Substitution - Missense
c.700C>G; p.H234D; 16:58040134-58040134	liver	carcinoma	Substitution - Missense
c.543G>T; p.E181D; 16:58039977-58039977	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1884G>A; p.M628I; 16:58045320-58045320	skin	malignant_melanoma	Substitution - Missense
c.748+1G>A; p.?; 16:58040183-58040183	urinary_tract; bladder	carcinoma	Unknown
c.1220C>T; p.P407L; 16:58042286-58042286	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.765G>A; p.L255L; 16:58040553-58040553	skin	malignant_melanoma	Substitution - coding silent
c.373C>A; p.L125M; 16:58038327-58038327	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1039C>T; p.P347S; 16:58041745-58041745	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1484G>T; p.R495L; 16:58043541-58043541	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.949C>A; p.P317T; 16:58041655-58041655	liver	carcinoma	Substitution - Missense
c.1500C>T; p.Y500Y; 16:58043557-58043557	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation