lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4319
Symbol	MMP10
Synonymous	SL-2\|STMY2
Full name	matrix metallopeptidase 10
Gene description	MMP-10\|matrix metalloprotease 10\|matrix metalloproteinase 10 (stromelysin 2)\|matrix metalloproteinase-10\|stromelysin 2\|stromelysin-2\|transin 2\|transin-2
Cytoband	11q22.3
Gene type	protein-coding
Synonymous	MIM:185260; HGNC:HGNC:7156; Ensembl:ENSG00000166670; HPRD:01704; Vega:OTTHUMG00000168083

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.943C>T; p.R315*; 11:102775311-102775311	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.943C>T; p.R315*; 11:102775311-102775311	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.562C>A; p.P188T; 11:102778684-102778684	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.222_223insC; p.T75fs*7; 11:102779628-102779629	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Insertion - Frameshift
c.518T>G; p.F173C; 11:102778728-102778728	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1210G>A; p.A404T; 11:102772863-102772863	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.107A>G; p.Q36R; 11:102779744-102779744	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.620C>T; p.S207L; 11:102778626-102778626	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.897C>A; p.S299R; 11:102776315-102776315	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1183G>A; p.E395K; 11:102772890-102772890	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.820G>T; p.V274L; 11:102776392-102776392	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.285C>T; p.D95D; 11:102779566-102779566	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.477G>A; p.M159I; 11:102779232-102779232	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.424G>C; p.E142Q; 11:102779285-102779285	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.1190A>C; p.K397T; 11:102772883-102772883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.79G>A; p.E27K; 11:102780513-102780513	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.387_388insA; p.D130fs*5; 11:102779321-102779322	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.194G>A; p.G65E; 11:102779657-102779657	skin	malignant_melanoma	Substitution - Missense
c.742T>C; p.F248L; 11:102776657-102776657	breast	carcinoma	Substitution - Missense
c.10C>G; p.L4V; 11:102780582-102780582	thyroid	other; neoplasm	Substitution - Missense
c.1203C>A; p.F401L; 11:102772870-102772870	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.791C>A; p.P264H; 11:102776421-102776421	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.227G>A; p.G76E; 11:102779624-102779624	skin	malignant_melanoma	Substitution - Missense
c.467C>T; p.A156V; 11:102779242-102779242	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.193G>A; p.G65R; 11:102779658-102779658	skin	malignant_melanoma	Substitution - Missense
c.1156A>G; p.K386E; 11:102772917-102772917	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.259C>T; p.R87C; 11:102779592-102779592	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.259C>T; p.R87C; 11:102779592-102779592	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.259C>T; p.R87C; 11:102779592-102779592	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.207C>A; p.F69L; 11:102779644-102779644	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.375A>G; p.P125P; 11:102779334-102779334	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.375A>G; p.P125P; 11:102779334-102779334	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.139G>T; p.D47Y; 11:102779712-102779712	skin	malignant_melanoma	Substitution - Missense
c.799G>A; p.A267T; 11:102776413-102776413	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.799G>A; p.A267T; 11:102776413-102776413	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.510T>G; p.F170L; 11:102778736-102778736	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1016T>C; p.L339S; 11:102775238-102775238	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.405A>G; p.K135K; 11:102779304-102779304	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.496+2T>C; p.?; 11:102779211-102779211	central_nervous_system; brain	glioma	Unknown
c.515C>T; p.S172F; 11:102778731-102778731	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.129C>A; p.N43K; 11:102779722-102779722	oesophagus	carcinoma	Substitution - Missense
c.311G>T; p.G104V; 11:102779540-102779540	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.916C>A; p.L306M; 11:102776296-102776296	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.916C>A; p.L306M; 11:102776296-102776296	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1386G>A; p.R462R; 11:102770838-102770838	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.787G>T; p.G263*; 11:102776612-102776612	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.1122C>T; p.G374G; 11:102772951-102772951	ovary	other; neoplasm	Substitution - coding silent
c.574G>A; p.G192R; 11:102778672-102778672	breast	carcinoma	Substitution - Missense
c.574G>A; p.G192R; 11:102778672-102778672	skin	malignant_melanoma	Substitution - Missense
c.1320A>T; p.L440F; 11:102772022-102772022	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1205T>G; p.F402C; 11:102772868-102772868	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.948A>G; p.R316R; 11:102775306-102775306	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.923T>A; p.F308Y; 11:102776289-102776289	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.93G>A; p.K31K; 11:102780499-102780499	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1124T>C; p.I375T; 11:102772949-102772949	liver	carcinoma	Substitution - Missense
c.1022C>T; p.A341V; 11:102775232-102775232	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.348-1G>T; p.?; 11:102779362-102779362	stomach	carcinoma; adenocarcinoma	Unknown
c.1095T>G; p.N365K; 11:102772978-102772978	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.187_188insA; p.I63fs*19; 11:102779663-102779664	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.503G>A; p.G168E; 11:102778743-102778743	skin	malignant_melanoma	Substitution - Missense
c.447C>A; p.S149S; 11:102779262-102779262	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.407C>A; p.A136D; 11:102779302-102779302	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.944G>A; p.R315Q; 11:102775310-102775310	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.502G>A; p.G168R; 11:102778744-102778744	skin	malignant_melanoma	Substitution - Missense
c.944G>A; p.R315Q; 11:102775310-102775310	oesophagus	carcinoma	Substitution - Missense
c.961C>T; p.P321S; 11:102775293-102775293	skin	malignant_melanoma	Substitution - Missense
c.400G>A; p.E134K; 11:102779309-102779309	skin	malignant_melanoma	Substitution - Missense
c.187delA; p.I63fs*12; 11:102779664-102779664	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1155G>A; p.R385R; 11:102772918-102772918	skin	malignant_melanoma	Substitution - coding silent
c.266C>G; p.P89R; 11:102779585-102779585	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.796C>G; p.P266A; 11:102776416-102776416	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.776A>G; p.Q259R; 11:102776623-102776623	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.344delA; p.Y115fs*4; 11:102779507-102779507	liver	carcinoma; hepatocellular_carcinoma	Deletion - Frameshift
c.867T>C; p.C289C; 11:102776345-102776345	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.746G>A; p.R249H; 11:102776653-102776653	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1001C>G; p.S334C; 11:102775253-102775253	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1429T>C; p.*477Q; 11:102770795-102770795	central_nervous_system; brainstem	glioma; astrocytoma_Grade_III	Nonstop extension
c.886G>A; p.D296N; 11:102776326-102776326	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.189C>T; p.I63I; 11:102779662-102779662	skin	malignant_melanoma	Substitution - coding silent
c.373C>T; p.P125S; 11:102779336-102779336	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1335T>G; p.F445L; 11:102770889-102770889	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.425A>G; p.E142G; 11:102779284-102779284	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.425A>G; p.E142G; 11:102779284-102779284	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.486T>C; p.F162F; 11:102779223-102779223	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.811G>T; p.E271*; 11:102776401-102776401	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.176T>G; p.I59S; 11:102779675-102779675	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.159_162delAAAG; p.K54fs*20; 11:102779689-102779692	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.749T>G; p.L250R; 11:102776650-102776650	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.283G>C; p.D95H; 11:102779568-102779568	breast	carcinoma	Substitution - Missense
c.1088G>T; p.R363I; 11:102772985-102772985	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.827C>T; p.T276I; 11:102776385-102776385	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.452T>A; p.L151Q; 11:102779257-102779257	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.621A>C; p.S207S; 11:102778625-102778625	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.510_511delTT; p.F170fs*4; 11:102778735-102778736	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.916C>T; p.L306L; 11:102776296-102776296	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.169A>G; p.N57D; 11:102779682-102779682	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1006C>T; p.P336S; 11:102775248-102775248	skin	malignant_melanoma	Substitution - Missense
c.1006C>T; p.P336S; 11:102775248-102775248	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation