lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4317
Symbol	MMP8
Synonymous	CLG1\|HNC\|MMP-8\|PMNL-CL
Full name	matrix metallopeptidase 8
Gene description	PMN leukocyte collagenase\|PMNL collagenase\|collagenase 2\|matrix metalloproteinase 8 (neutrophil collagenase)\|matrix metalloproteinase-8\|neutrophil collagenase
Cytoband	11q22.3
Gene type	protein-coding
Synonymous	MIM:120355; HGNC:HGNC:7175; Ensembl:ENSG00000118113; HPRD:00385; Vega:OTTHUMG00000167587

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1305T>A; p.H435Q; 11:102713447-102713447	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.872T>C; p.L291P; 11:102716332-102716332	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.872T>C; p.L291P; 11:102716332-102716332	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.872T>C; p.L291P; 11:102716332-102716332	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.842C>A; p.P281H; 11:102716362-102716362	central_nervous_system; brain	glioma	Substitution - Missense
c.224C>T; p.T75M; 11:102722552-102722552	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.594C>T; p.A198A; 11:102721429-102721429	thyroid	other; neoplasm	Substitution - coding silent
c.275G>A; p.G92E; 11:102722501-102722501	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.661C>A; p.H221N; 11:102718537-102718537	breast	carcinoma	Substitution - Missense
c.593C>T; p.A198V; 11:102721430-102721430	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.593C>T; p.A198V; 11:102721430-102721430	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.29T>A; p.L10Q; 11:102724827-102724827	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.177C>T; p.I59I; 11:102722599-102722599	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.24A>G; p.P8P; 11:102724832-102724832	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.177C>T; p.I59I; 11:102722599-102722599	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.177C>T; p.I59I; 11:102722599-102722599	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.177C>T; p.I59I; 11:102722599-102722599	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.325G>A; p.E109K; 11:102722451-102722451	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.935G>C; p.R312T; 11:102715405-102715405	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.935G>C; p.R312T; 11:102715405-102715405	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.283G>A; p.D95N; 11:102722493-102722493	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.939C>T; p.V313V; 11:102715401-102715401	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.940G>A; p.E314K; 11:102715400-102715400	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.940G>A; p.E314K; 11:102715400-102715400	skin; abdomen	malignant_melanoma	Substitution - Missense
c.1379A>C; p.K460T; 11:102713373-102713373	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.268C>T; p.R90C; 11:102722508-102722508	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.33C>T; p.L11L; 11:102724823-102724823	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1084C>T; p.P362S; 11:102714662-102714662	skin; upper_leg	malignant_melanoma	Substitution - Missense
c.1084C>T; p.P362S; 11:102714662-102714662	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.583C>A; p.H195N; 11:102721440-102721440	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.439A>T; p.I147F; 11:102721671-102721671	skin	malignant_melanoma	Substitution - Missense
c.537C>T; p.I179I; 11:102721486-102721486	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.310G>A; p.G104R; 11:102722466-102722466	skin; chest	malignant_melanoma	Substitution - Missense
c.691C>T; p.P231S; 11:102718507-102718507	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.606G>C; p.W202C; 11:102721417-102721417	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.867C>T; p.T289T; 11:102716337-102716337	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.827C>A; p.P276H; 11:102716377-102716377	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1201C>A; p.Q401K; 11:102713847-102713847	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.951T>C; p.F317F; 11:102715389-102715389	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1134C>T; p.D378D; 11:102714612-102714612	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.873C>T; p.L291L; 11:102716331-102716331	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.873C>T; p.L291L; 11:102716331-102716331	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.956C>A; p.S319Y; 11:102715384-102715384	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.149C>T; p.S50F; 11:102722627-102722627	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.178G>A; p.V60I; 11:102722598-102722598	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.149C>T; p.S50F; 11:102722627-102722627	skin; shoulder	malignant_melanoma	Substitution - Missense
c.181G>A; p.E61K; 11:102722595-102722595	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.885A>G; p.I295M; 11:102716319-102716319	skin	malignant_melanoma	Substitution - Missense
c.1120G>A; p.V374I; 11:102714626-102714626	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1308C>A; p.V436V; 11:102713444-102713444	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.234A>C; p.P78P; 11:102722542-102722542	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.8C>G; p.S3C; 11:102724848-102724848	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1273G>C; p.D425H; 11:102713775-102713775	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.960A>G; p.L320L; 11:102715380-102715380	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.412G>C; p.E138Q; 11:102721698-102721698	skin; lower_leg	malignant_melanoma	Substitution - Missense
c.903-5G>T; p.?; 11:102715442-102715442	liver	carcinoma	Unknown
c.311G>A; p.G104E; 11:102722465-102722465	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.112G>A; p.E38K; 11:102722664-102722664	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.112G>A; p.E38K; 11:102722664-102722664	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.457C>A; p.Q153K; 11:102721653-102721653	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1078G>A; p.G360S; 11:102714668-102714668	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.876T>C; p.R292R; 11:102716328-102716328	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.876T>C; p.R292R; 11:102716328-102716328	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1274A>G; p.D425G; 11:102713774-102713774	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1274A>G; p.D425G; 11:102713774-102713774	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1274A>G; p.D425G; 11:102713774-102713774	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1274A>G; p.D425G; 11:102713774-102713774	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1274A>G; p.D425G; 11:102713774-102713774	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.532G>T; p.G178*; 11:102721491-102721491	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.114A>G; p.E38E; 11:102722662-102722662	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.62T>C; p.F21S; 11:102724794-102724794	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.261A>C; p.K87N; 11:102722515-102722515	skin; face	malignant_melanoma	Substitution - Missense
c.1295-5delT; p.?; 11:102713462-102713462	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.1295-5delT; p.?; 11:102713462-102713462	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.814G>A; p.G272R; 11:102716390-102716390	liver	carcinoma	Substitution - Missense
c.814G>A; p.G272R; 11:102716390-102716390	liver	carcinoma	Substitution - Missense
c.512C>T; p.S171F; 11:102721511-102721511	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1036+2T>A; p.?; 11:102715302-102715302	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.836G>T; p.C279F; 11:102716368-102716368	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.787C>T; p.L263F; 11:102716417-102716417	skin	malignant_melanoma	Substitution - Missense
c.202C>T; p.R68*; 11:102722574-102722574	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1330G>T; p.A444S; 11:102713422-102713422	thyroid	carcinoma	Substitution - Missense
c.665C>A; p.S222Y; 11:102718533-102718533	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.172G>T; p.V58L; 11:102722604-102722604	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.286A>T; p.S96C; 11:102722490-102722490	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.286A>T; p.S96C; 11:102722490-102722490	liver	carcinoma	Substitution - Missense
c.217A>C; p.N73H; 11:102722559-102722559	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.232C>T; p.P78S; 11:102722544-102722544	skin; face	malignant_melanoma	Substitution - Missense
c.1261G>C; p.E421Q; 11:102713787-102713787	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1294+9G>A; p.?; 11:102713745-102713745	liver	carcinoma	Unknown
c.1140T>A; p.A380A; 11:102714606-102714606	pancreas	carcinoid-endocrine_tumour	Substitution - coding silent
c.210delT; p.F70fs*3; 11:102722566-102722566	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.533G>A; p.G178E; 11:102721490-102721490	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.533G>A; p.G178E; 11:102721490-102721490	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.875G>T; p.R292L; 11:102716329-102716329	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.126A>G; p.Q42Q; 11:102722650-102722650	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.126A>G; p.Q42Q; 11:102722650-102722650	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.104A>G; p.D35G; 11:102722672-102722672	liver	carcinoma	Substitution - Missense
c.104A>G; p.D35G; 11:102722672-102722672	liver	carcinoma	Substitution - Missense
c.514C>T; p.P172S; 11:102721509-102721509	skin	malignant_melanoma	Substitution - Missense
c.385G>A; p.V129I; 11:102721725-102721725	skin	malignant_melanoma	Substitution - Missense
c.1139C>T; p.A380V; 11:102714607-102714607	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.762C>T; p.I254I; 11:102718436-102718436	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.762C>T; p.I254I; 11:102718436-102718436	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.762C>T; p.I254I; 11:102718436-102718436	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.903-1G>A; p.?; 11:102715438-102715438	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.762C>T; p.I254I; 11:102718436-102718436	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.917G>T; p.R306M; 11:102715423-102715423	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.89C>A; p.T30K; 11:102724767-102724767	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1026C>T; p.F342F; 11:102715314-102715314	skin	malignant_melanoma	Substitution - coding silent
c.469G>T; p.D157Y; 11:102721641-102721641	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.1188G>C; p.W396C; 11:102714558-102714558	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1326T>G; p.Y442*; 11:102713426-102713426	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.880G>T; p.E294*; 11:102716324-102716324	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1242A>C; p.S414S; 11:102713806-102713806	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.113A>G; p.E38G; 11:102722663-102722663	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1041C>T; p.N347N; 11:102714705-102714705	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1A>C; p.M1L; 11:102724855-102724855	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.707A>C; p.Y236S; 11:102718491-102718491	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.272G>T; p.C91F; 11:102722504-102722504	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.874C>T; p.R292C; 11:102716330-102716330	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation