lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4277
Symbol	MICB
Synonymous	PERB11.2
Full name	MHC class I polypeptide-related sequence B
Gene description	MHC class I chain-related protein B\|MHC class I mic-B antigen\|MHC class I-like molecule PERB11.2-IMX\|stress inducible class I homolog
Cytoband	6p21.3
Gene type	protein-coding
Synonymous	MIM:602436; HGNC:HGNC:7091; Ensembl:ENSG00000204516; HPRD:03894; Vega:OTTHUMG00000031074

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.163C>T; p.P55S; 6:31505709-31505709	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.502T>A; p.F168I; 6:31506319-31506319	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.502T>A; p.F168I; 6:31506319-31506319	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.779G>T; p.G260V; 6:31507187-31507187	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.502T>A; p.F168I; 6:31506319-31506319	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.906G>A; p.V302V; 6:31507413-31507413	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.556G>C; p.D186H; 6:31506373-31506373	breast	carcinoma	Substitution - Missense
c.543C>T; p.R181R; 6:31506360-31506360	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1087G>A; p.A363T; 6:31509844-31509844	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1026G>T; p.E342D; 6:31509783-31509783	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1026G>C; p.E342D; 6:31509783-31509783	skin	malignant_melanoma	Substitution - Missense
c.285C>T; p.D95D; 6:31505831-31505831	skin	malignant_melanoma	Substitution - coding silent
c.9_10GG>TT; p.G4C; 6:31498202-31498203	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.322G>A; p.G108R; 6:31505868-31505868	skin	malignant_melanoma	Substitution - Missense
c.544G>A; p.A182T; 6:31506361-31506361	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.534A>C; p.T178T; 6:31506351-31506351	breast	carcinoma	Substitution - coding silent
c.870C>T; p.H290H; 6:31507278-31507278	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1105C>T; p.P369S; 6:31509862-31509862	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.951G>A; p.M317I; 6:31507458-31507458	breast	carcinoma	Substitution - Missense
c.492C>T; p.N164N; 6:31506309-31506309	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.406G>A; p.D136N; 6:31506223-31506223	central_nervous_system; brainstem	glioma; oligoastrocytoma_Grade_III	Substitution - Missense
c.406G>A; p.D136N; 6:31506223-31506223	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.485C>T; p.A162V; 6:31506302-31506302	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.263A>G; p.D88G; 6:31505809-31505809	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1136C>T; p.S379F; 6:31509893-31509893	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.145G>A; p.G49R; 6:31505691-31505691	skin	malignant_melanoma	Substitution - Missense
c.758delG; p.D255fs*90; 6:31507166-31507166	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.829G>A; p.E277K; 6:31507237-31507237	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.110A>G; p.Q37R; 6:31505656-31505656	urinary_tract; bladder	carcinoma	Substitution - Missense
c.238A>G; p.K80E; 6:31505784-31505784	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.325G>T; p.G109C; 6:31505871-31505871	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.424T>C; p.S142P; 6:31506241-31506241	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; large_cell	Substitution - Missense
c.76C>T; p.H26Y; 6:31505622-31505622	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.146G>A; p.G49E; 6:31505692-31505692	NS	malignant_melanoma	Substitution - Missense
c.190C>T; p.R64C; 6:31505736-31505736	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.932C>T; p.P311L; 6:31507439-31507439	skin	malignant_melanoma	Substitution - Missense
c.144G>A; p.E48E; 6:31505690-31505690	central_nervous_system; brain	glioma	Substitution - coding silent
c.968T>A; p.I323N; 6:31507475-31507475	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.684C>T; p.S228S; 6:31507092-31507092	skin	malignant_melanoma	Substitution - coding silent
c.1096G>A; p.G366R; 6:31509853-31509853	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.164C>T; p.P55L; 6:31505710-31505710	skin	malignant_melanoma	Substitution - Missense
c.86G>A; p.R29H; 6:31505632-31505632	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.363C>G; p.I121M; 6:31506180-31506180	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.363C>G; p.I121M; 6:31506180-31506180	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.363C>G; p.I121M; 6:31506180-31506180	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.775G>T; p.D259Y; 6:31507183-31507183	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.680C>T; p.A227V; 6:31507088-31507088	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.680C>T; p.A227V; 6:31507088-31507088	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.719G>A; p.R240H; 6:31507127-31507127	skin	malignant_melanoma	Substitution - Missense
c.996G>A; p.K332K; 6:31507503-31507503	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.581A>G; p.Y194C; 6:31506398-31506398	kidney	other; neoplasm	Substitution - Missense
c.207G>T; p.Q69H; 6:31505753-31505753	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.405C>T; p.Y135Y; 6:31506222-31506222	central_nervous_system; brain	glioma	Substitution - coding silent
c.520A>T; p.M174L; 6:31506337-31506337	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1072G>A; p.D358N; 6:31509829-31509829	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.806C>T; p.A269V; 6:31507214-31507214	ovary	other; neoplasm	Substitution - Missense
c.531G>A; p.K177K; 6:31506348-31506348	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1015G>T; p.E339*; 6:31507522-31507522	skin	malignant_melanoma	Substitution - Nonsense
c.1110G>C; p.L370L; 6:31509867-31509867	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1146C>T; p.G382G; 6:31509903-31509903	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.985C>T; p.P329S; 6:31507492-31507492	skin	malignant_melanoma	Substitution - Missense
c.541C>T; p.R181C; 6:31506358-31506358	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.893G>A; p.G298E; 6:31507400-31507400	skin	malignant_melanoma	Substitution - Missense
c.718C>T; p.R240C; 6:31507126-31507126	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1017G>A; p.E339E; 6:31507524-31507524	liver	carcinoma	Substitution - coding silent
c.1017G>A; p.E339E; 6:31507524-31507524	liver	carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation