lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4176
Symbol	MCM7
Synonymous	CDC47\|MCM2\|P1.1-MCM3\|P1CDC47\|P85MCM\|PNAS146\|PPP1R104
Full name	minichromosome maintenance complex component 7
Gene description	CDC47 homolog\|DNA replication licensing factor MCM7\|homolog of S. cerevisiae Cdc47\|minichromosome maintenance deficient 7\|protein phosphatase 1, regulatory subunit 104
Cytoband	7q21.3-q22.1
Gene type	protein-coding
Synonymous	MIM:600592; HGNC:HGNC:6950; Ensembl:ENSG00000166508; HPRD:01154; Vega:OTTHUMG00000154671

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1267A>C; p.T423P; 7:100094226-100094226	breast	carcinoma	Substitution - Missense
c.1045C>A; p.P349T; 7:100095796-100095796	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1268C>T; p.T423I; 7:100094225-100094225	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.328C>T; p.R110*; 7:100098155-100098155	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; essential_thrombocythaemia	Substitution - Nonsense
c.328C>T; p.R110*; 7:100098155-100098155	skin	malignant_melanoma	Substitution - Nonsense
c.1357G>C; p.D453H; 7:100093365-100093365	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.897C>T; p.L299L; 7:100095944-100095944	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.768G>A; p.G256G; 7:100096073-100096073	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.768G>A; p.G256G; 7:100096073-100096073	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.658C>T; p.R220*; 7:100097316-100097316	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.269A>G; p.Q90R; 7:100098214-100098214	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.549C>T; p.V183V; 7:100097654-100097654	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1154G>A; p.R385H; 7:100094339-100094339	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.410A>C; p.E137A; 7:100097881-100097881	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.637C>T; p.Q213*; 7:100097337-100097337	breast	carcinoma	Substitution - Nonsense
c.635C>G; p.S212C; 7:100097339-100097339	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.640C>G; p.L214V; 7:100097334-100097334	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.635C>G; p.S212C; 7:100097339-100097339	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.532C>T; p.L178L; 7:100097671-100097671	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.215A>G; p.N72S; 7:100098268-100098268	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.929C>A; p.A310D; 7:100095912-100095912	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1241G>A; p.R414Q; 7:100094252-100094252	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.508G>T; p.G170W; 7:100097695-100097695	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1116delC; p.S373fs*8; 7:100095422-100095422	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1503C>A; p.F501L; 7:100093061-100093061	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.274G>A; p.G92R; 7:100098209-100098209	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1545C>T; p.P515P; 7:100093019-100093019	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1304G>A; p.R435H; 7:100094189-100094189	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.512A>G; p.H171R; 7:100097691-100097691	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.289G>A; p.V97I; 7:100098194-100098194	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1203G>T; p.L401L; 7:100094290-100094290	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.647C>T; p.S216L; 7:100097327-100097327	breast	carcinoma	Substitution - Missense
c.471C>T; p.Y157Y; 7:100097732-100097732	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.882C>T; p.A294A; 7:100095959-100095959	skin	malignant_melanoma	Substitution - coding silent
c.1479C>G; p.V493V; 7:100093085-100093085	breast	carcinoma	Substitution - coding silent
c.165A>C; p.K55N; 7:100098605-100098605	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1391C>A; p.S464*; 7:100093331-100093331	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.466T>G; p.F156V; 7:100097737-100097737	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.355G>C; p.E119Q; 7:100097936-100097936	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1560G>A; p.A520A; 7:100093004-100093004	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.813C>T; p.F271F; 7:100096028-100096028	skin	malignant_melanoma	Substitution - coding silent
c.1516C>T; p.Q506*; 7:100093048-100093048	liver	carcinoma	Substitution - Nonsense
c.813C>T; p.F271F; 7:100096028-100096028	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1516C>T; p.Q506*; 7:100093048-100093048	liver	carcinoma	Substitution - Nonsense
c.444G>C; p.L148L; 7:100097847-100097847	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.717G>A; p.T239T; 7:100096124-100096124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.472G>A; p.E158K; 7:100097731-100097731	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.472G>A; p.E158K; 7:100097731-100097731	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.722C>G; p.A241G; 7:100096119-100096119	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.386A>G; p.K129R; 7:100097905-100097905	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.493G>A; p.A165T; 7:100097710-100097710	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.912C>T; p.A304A; 7:100095929-100095929	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.55-1G>T; p.?; 7:100098716-100098716	lung; right_upper_lobe	carcinoma; adenocarcinoma	Unknown
c.1297A>G; p.I433V; 7:100094196-100094196	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.116G>T; p.R39L; 7:100098654-100098654	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.631A>G; p.K211E; 7:100097343-100097343	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.733G>A; p.D245N; 7:100096108-100096108	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.995C>T; p.P332L; 7:100095846-100095846	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.550G>A; p.G184R; 7:100097653-100097653	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.550G>A; p.G184R; 7:100097653-100097653	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.459G>T; p.E153D; 7:100097744-100097744	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1119C>T; p.S373S; 7:100095419-100095419	skin	malignant_melanoma	Substitution - coding silent
c.285C>T; p.V95V; 7:100098198-100098198	skin	malignant_melanoma	Substitution - coding silent
c.1051C>T; p.R351*; 7:100095790-100095790	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.835C>T; p.R279C; 7:100096006-100096006	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1361T>C; p.V454A; 7:100093361-100093361	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.342G>A; p.Q114Q; 7:100098141-100098141	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1105C>T; p.R369W; 7:100095433-100095433	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.488C>A; p.S163*; 7:100097715-100097715	breast	carcinoma	Substitution - Nonsense
c.674G>C; p.S225T; 7:100096167-100096167	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1243G>T; p.E415*; 7:100094250-100094250	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1419G>A; p.G473G; 7:100093303-100093303	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.547G>T; p.V183F; 7:100097656-100097656	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.690C>A; p.G230G; 7:100096151-100096151	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1417G>A; p.G473R; 7:100093305-100093305	skin	malignant_melanoma	Substitution - Missense
c.1243G>A; p.E415K; 7:100094250-100094250	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.631_632delAA; p.K211fs*8; 7:100097342-100097343	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Deletion - Frameshift
c.1157A>G; p.Y386C; 7:100094336-100094336	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1052G>A; p.R351Q; 7:100095789-100095789	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1227C>T; p.Y409Y; 7:100094266-100094266	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1227C>T; p.Y409Y; 7:100094266-100094266	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.836G>A; p.R279H; 7:100096005-100096005	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.327C>A; p.F109L; 7:100098156-100098156	skin	malignant_melanoma	Substitution - Missense
c.1013G>A; p.R338Q; 7:100095828-100095828	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.510G>A; p.G170G; 7:100097693-100097693	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.507C>T; p.Y169Y; 7:100097696-100097696	bone; pelvis	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.192+1G>A; p.?; 7:100098577-100098577	oesophagus	carcinoma	Unknown
c.1497C>G; p.V499V; 7:100093067-100093067	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1043G>T; p.R348L; 7:100095798-100095798	stomach	adenocarcinoma	Substitution - Missense
c.1066C>T; p.R356W; 7:100095775-100095775	ovary	carcinoma; adenocarcinoma	Substitution - Missense
c.1591T>C; p.W531R; 7:100092973-100092973	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.538C>T; p.L180F; 7:100097665-100097665	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.715A>T; p.T239S; 7:100096126-100096126	large_intestine; colon	carcinoma	Substitution - Missense
c.1211A>T; p.Y404F; 7:100094282-100094282	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.715A>T; p.T239S; 7:100096126-100096126	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.715A>T; p.T239S; 7:100096126-100096126	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1048G>A; p.D350N; 7:100095793-100095793	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.551G>A; p.G184E; 7:100097652-100097652	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.34G>A; p.G12R; 7:100099043-100099043	thyroid	other; neoplasm	Substitution - Missense
c.1008C>T; p.L336L; 7:100095833-100095833	oesophagus; upper_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1440A>G; p.R480R; 7:100093124-100093124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.629C>A; p.A210D; 7:100097345-100097345	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1118C>T; p.S373F; 7:100095420-100095420	skin	malignant_melanoma	Substitution - Missense
c.1118C>T; p.S373F; 7:100095420-100095420	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.670C>T; p.R224C; 7:100097304-100097304	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.670C>T; p.R224C; 7:100097304-100097304	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.670C>T; p.R224C; 7:100097304-100097304	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1118C>T; p.S373F; 7:100095420-100095420	skin	malignant_melanoma	Substitution - Missense
c.718G>A; p.A240T; 7:100096123-100096123	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1574A>G; p.Y525C; 7:100092990-100092990	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.710G>A; p.G237E; 7:100096131-100096131	stomach	adenocarcinoma	Substitution - Missense
c.985A>G; p.I329V; 7:100095856-100095856	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.234G>A; p.T78T; 7:100098249-100098249	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.283G>T; p.V95F; 7:100098200-100098200	haematopoietic_and_lymphoid_tissue; skin	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.775G>A; p.V259M; 7:100096066-100096066	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.125G>A; p.G42E; 7:100098645-100098645	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.550G>T; p.G184W; 7:100097653-100097653	urinary_tract; bladder	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation