lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4102
Symbol	MAGEA3
Synonymous	CT1.3\|HIP8\|HYPD\|MAGE3\|MAGEA6
Full name	melanoma antigen family A3
Gene description	MAGE-3 antigen\|antigen MZ2-D\|cancer/testis antigen 1.3\|cancer/testis antigen family 1, member 3\|melanoma antigen family A, 3\|melanoma-associated antigen 3
Cytoband	Xq28
Gene type	protein-coding
Synonymous	MIM:300174; HGNC:HGNC:6801; Ensembl:ENSG00000221867; HPRD:02166; Vega:OTTHUMG00000022640

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.640G>C; p.D214H; 23:152701472-152701472	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.242G>T; p.S81I; 23:152701074-152701074	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.438C>G; p.F146L; 23:152701270-152701270	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.937G>A; p.E313K; 23:152701769-152701769	skin	malignant_melanoma	Substitution - Missense
c.480G>T; p.L160L; 23:152701312-152701312	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.446T>C; p.V149A; 23:152701278-152701278	central_nervous_system; brain	glioma	Substitution - Missense
c.702G>A; p.R234R; 23:152701534-152701534	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.282G>A; p.G94G; 23:152701114-152701114	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.238T>G; p.W80G; 23:152701070-152701070	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.253G>C; p.E85Q; 23:152701085-152701085	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.899C>T; p.S300F; 23:152701731-152701731	skin	malignant_melanoma	Substitution - Missense
c.899C>T; p.S300F; 23:152701731-152701731	skin	malignant_melanoma	Substitution - Missense
c.899C>T; p.S300F; 23:152701731-152701731	skin	malignant_melanoma	Substitution - Missense
c.615C>T; p.V205V; 23:152701447-152701447	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.823C>T; p.P275S; 23:152701655-152701655	skin	malignant_melanoma	Substitution - Missense
c.615C>T; p.V205V; 23:152701447-152701447	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.777G>T; p.R259R; 23:152701609-152701609	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.835G>A; p.V279I; 23:152701667-152701667	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.677G>T; p.S226I; 23:152701509-152701509	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.580C>T; p.Q194*; 23:152701412-152701412	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.232C>T; p.P78S; 23:152701064-152701064	skin	malignant_melanoma	Substitution - Missense
c.714C>A; p.I238I; 23:152701546-152701546	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.632G>A; p.R211K; 23:152701464-152701464	skin	malignant_melanoma	Substitution - Missense
c.559G>A; p.D187N; 23:152701391-152701391	skin	malignant_melanoma	Substitution - Missense
c.559G>A; p.D187N; 23:152701391-152701391	skin	malignant_melanoma	Substitution - Missense
c.751G>T; p.V251L; 23:152701583-152701583	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.470C>T; p.S157F; 23:152701302-152701302	skin	malignant_melanoma	Substitution - Missense
c.502G>T; p.E168*; 23:152701334-152701334	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.883G>A; p.G295R; 23:152701715-152701715	skin	malignant_melanoma	Substitution - Missense
c.352C>A; p.H118N; 23:152701184-152701184	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.55C>T; p.R19*; 23:152700887-152700887	breast	carcinoma	Substitution - Nonsense
c.893A>G; p.H298R; 23:152701725-152701725	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.545T>C; p.L182P; 23:152701377-152701377	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.634G>T; p.E212*; 23:152701466-152701466	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.417C>T; p.V139V; 23:152701249-152701249	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.309C>A; p.S103S; 23:152701141-152701141	bone; humerus	chondrosarcoma	Substitution - coding silent
c.523T>G; p.L175V; 23:152701355-152701355	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.481G>A; p.V161I; 23:152701313-152701313	skin	malignant_melanoma	Substitution - Missense
c.281G>A; p.G94E; 23:152701113-152701113	skin	malignant_melanoma	Substitution - Missense
c.813C>T; p.F271F; 23:152701645-152701645	skin	malignant_melanoma	Substitution - coding silent
c.352C>T; p.H118Y; 23:152701184-152701184	skin	malignant_melanoma	Substitution - Missense
c.940G>A; p.E314K; 23:152701772-152701772	breast	carcinoma	Substitution - Missense
c.906A>C; p.P302P; 23:152701738-152701738	breast	carcinoma	Substitution - coding silent
c.738C>G; p.L246L; 23:152701570-152701570	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.810A>G; p.E270E; 23:152701642-152701642	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.908C>T; p.P303L; 23:152701740-152701740	skin	malignant_melanoma	Substitution - Missense
c.460G>C; p.A154P; 23:152701292-152701292	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.721G>A; p.D241N; 23:152701553-152701553	skin	malignant_melanoma	Substitution - Missense
c.657G>T; p.E219D; 23:152701489-152701489	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.882T>C; p.S294S; 23:152701714-152701714	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.768G>C; p.L256L; 23:152701600-152701600	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.634_641delGAGGGCGA; p.E212fs*4; 23:152701466-152701473	liver	carcinoma	Deletion - Frameshift
c.418G>A; p.V140I; 23:152701250-152701250	breast	carcinoma	Substitution - Missense
c.831C>T; p.A277A; 23:152701663-152701663	skin	malignant_melanoma	Substitution - coding silent
c.387G>A; p.P129P; 23:152701219-152701219	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.530T>A; p.I177N; 23:152701362-152701362	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.766C>G; p.L256V; 23:152701598-152701598	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.729G>A; p.K243K; 23:152701561-152701561	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.639C>T; p.G213G; 23:152701471-152701471	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.456C>T; p.S152S; 23:152701288-152701288	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.492C>T; p.I164I; 23:152701324-152701324	skin	malignant_melanoma	Substitution - coding silent
c.443C>T; p.P148L; 23:152701275-152701275	skin	malignant_melanoma	Substitution - Missense
c.492C>T; p.I164I; 23:152701324-152701324	skin	malignant_melanoma	Substitution - coding silent
c.628G>A; p.A210T; 23:152701460-152701460	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.750C>T; p.F250F; 23:152701582-152701582	skin	malignant_melanoma	Substitution - coding silent
c.750C>T; p.F250F; 23:152701582-152701582	skin	malignant_melanoma	Substitution - coding silent
c.750C>T; p.F250F; 23:152701582-152701582	skin	malignant_melanoma	Substitution - coding silent
c.750C>T; p.F250F; 23:152701582-152701582	skin	malignant_melanoma	Substitution - coding silent
c.750C>T; p.F250F; 23:152701582-152701582	skin	malignant_melanoma	Substitution - coding silent
c.421G>A; p.G141R; 23:152701253-152701253	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.430C>A; p.Q144K; 23:152701262-152701262	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.821G>C; p.G274A; 23:152701653-152701653	pleura	pulmonary_blastoma	Substitution - Missense
c.491T>G; p.I164S; 23:152701323-152701323	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.804T>C; p.C268C; 23:152701636-152701636	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.663C>T; p.I221I; 23:152701495-152701495	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.641A>G; p.D214G; 23:152701473-152701473	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.288C>A; p.S96R; 23:152701120-152701120	thyroid	carcinoma	Substitution - Missense
c.373C>T; p.R125*; 23:152701205-152701205	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.373C>T; p.R125*; 23:152701205-152701205	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation