lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4100
Symbol	MAGEA1
Synonymous	CT1.1\|MAGE1
Full name	melanoma antigen family A1
Gene description	MAGE-1 antigen\|antigen MZ2-E\|cancer/testis antigen 1.1\|cancer/testis antigen family 1, member 1\|melanoma antigen MAGE-1\|melanoma antigen family A 1\|melanoma antigen family A, 1 (directs expression of antigen MZ2-E)\|melanoma-associated antigen 1\|melanoma-a
Cytoband	Xq28
Gene type	protein-coding
Synonymous	MIM:300016; HGNC:HGNC:6796; Ensembl:ENSG00000198681; HPRD:02059; Vega:OTTHUMG00000024192

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.872G>T; p.R291L; 23:153183261-153183261	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.429C>A; p.I143I; 23:153182818-153182818	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.871C>T; p.R291C; 23:153183260-153183260	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.871C>T; p.R291C; 23:153183260-153183260	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.512T>C; p.L171P; 23:153182901-153182901	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.882C>T; p.F294F; 23:153183271-153183271	skin	malignant_melanoma	Substitution - coding silent
c.528T>C; p.G176G; 23:153182917-153182917	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.528T>C; p.G176G; 23:153182917-153182917	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.712C>A; p.L238M; 23:153183101-153183101	central_nervous_system; brainstem	glioma; astrocytoma_Grade_II	Substitution - Missense
c.332G>A; p.G111D; 23:153182721-153182721	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.559C>T; p.Q187*; 23:153182948-153182948	skin	malignant_melanoma	Substitution - Nonsense
c.694T>C; p.Y232H; 23:153183083-153183083	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; chronic_myeloid_leukaemia	Substitution - Missense
c.694T>C; p.Y232H; 23:153183083-153183083	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; chronic_myeloid_leukaemia	Substitution - Missense
c.333T>G; p.G111G; 23:153182722-153182722	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.813C>T; p.L271L; 23:153183202-153183202	kidney	other; neoplasm	Substitution - coding silent
c.432C>T; p.F144F; 23:153182821-153182821	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.666G>T; p.E222D; 23:153183055-153183055	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.833A>G; p.K278R; 23:153183222-153183222	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.564C>T; p.I188I; 23:153182953-153182953	skin	malignant_melanoma	Substitution - coding silent
c.389A>G; p.E130G; 23:153182778-153182778	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.472G>C; p.D158H; 23:153182861-153182861	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.553G>A; p.D185N; 23:153182942-153182942	skin	malignant_melanoma	Substitution - Missense
c.187G>C; p.A63P; 23:153182576-153182576	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.833A>C; p.K278T; 23:153183222-153183222	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.126C>T; p.T42T; 23:153182515-153182515	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.94A>G; p.T32A; 23:153182483-153182483	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.94A>G; p.T32A; 23:153182483-153182483	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.633_634GG>TT; p.E211_E212>D*; 23:153183022-153183023	lung	carcinoma; adenocarcinoma	Complex - compound substitution
c.513T>C; p.L171L; 23:153182902-153182902	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.214C>T; p.R72*; 23:153182603-153182603	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.793C>T; p.L265L; 23:153183182-153183182	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - coding silent
c.196A>G; p.T66A; 23:153182585-153182585	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.832A>G; p.K278E; 23:153183221-153183221	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.832A>G; p.K278E; 23:153183221-153183221	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.832A>G; p.K278E; 23:153183221-153183221	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.836T>C; p.V279A; 23:153183225-153183225	breast	carcinoma	Substitution - Missense
c.463T>C; p.F155L; 23:153182852-153182852	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.463T>C; p.F155L; 23:153182852-153182852	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.510C>T; p.V170V; 23:153182899-153182899	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.495C>T; p.T165T; 23:153182884-153182884	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.495C>T; p.T165T; 23:153182884-153182884	pancreas	carcinoma	Substitution - coding silent
c.664G>C; p.E222Q; 23:153183053-153183053	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.426G>A; p.E142E; 23:153182815-153182815	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.682G>A; p.E228K; 23:153183071-153183071	skin	malignant_melanoma	Substitution - Missense
c.24G>A; p.L8L; 23:153182413-153182413	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.494C>A; p.T165N; 23:153182883-153182883	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.697G>T; p.G233W; 23:153183086-153183086	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.833A>T; p.K278I; 23:153183222-153183222	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.442T>C; p.S148P; 23:153182831-153182831	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.381A>C; p.E127D; 23:153182770-153182770	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.698G>T; p.G233V; 23:153183087-153183087	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.511C>T; p.L171F; 23:153182900-153182900	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.511C>T; p.L171F; 23:153182900-153182900	skin	malignant_melanoma	Substitution - Missense
c.273T>C; p.S91S; 23:153182662-153182662	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.286T>C; p.S96P; 23:153182675-153182675	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.887C>T; p.S296F; 23:153183276-153183276	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.286T>C; p.S96P; 23:153182675-153182675	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.446A>G; p.E149G; 23:153182835-153182835	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.388G>A; p.E130K; 23:153182777-153182777	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.908G>A; p.R303K; 23:153183297-153183297	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.348A>G; p.K116K; 23:153182737-153182737	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.834A>G; p.K278K; 23:153183223-153183223	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.834A>G; p.K278K; 23:153183223-153183223	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.612G>A; p.M204I; 23:153183001-153183001	skin	malignant_melanoma	Substitution - Missense
c.573G>T; p.K191N; 23:153182962-153182962	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.309T>G; p.T103T; 23:153182698-153182698	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.619G>A; p.G207S; 23:153183008-153183008	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.135G>T; p.E45D; 23:153182524-153182524	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.488A>C; p.D163A; 23:153182877-153182877	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.893G>A; p.R298H; 23:153183282-153183282	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.658G>A; p.V220M; 23:153183047-153183047	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.10G>C; p.E4Q; 23:153182399-153182399	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.272C>A; p.S91Y; 23:153182661-153182661	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.736G>A; p.E246K; 23:153183125-153183125	skin	malignant_melanoma	Substitution - Missense
c.898G>A; p.A300T; 23:153183287-153183287	thyroid	carcinoma	Substitution - Missense
c.736G>A; p.E246K; 23:153183125-153183125	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.469A>G; p.I157V; 23:153182858-153182858	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.196A>T; p.T66S; 23:153182585-153182585	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.469A>G; p.I157V; 23:153182858-153182858	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.723A>C; p.Q241H; 23:153183112-153183112	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.559C>G; p.Q187E; 23:153182948-153182948	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.440C>T; p.A147V; 23:153182829-153182829	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.799G>A; p.G267S; 23:153183188-153183188	skin	malignant_melanoma	Substitution - Missense
c.879C>A; p.F293L; 23:153183268-153183268	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.319G>C; p.A107P; 23:153182708-153182708	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.194C>T; p.P65L; 23:153182583-153182583	skin	malignant_melanoma	Substitution - Missense
c.187G>A; p.A63T; 23:153182576-153182576	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation