lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4060
Symbol	LUM
Synonymous	LDC\|SLRR2D
Full name	lumican
Gene description	KSPG lumican\|keratan sulfate proteoglycan lumican\|lumican proteoglycan
Cytoband	12q21.33
Gene type	protein-coding
Synonymous	MIM:600616; HGNC:HGNC:6724; HPRD:02793

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.967C>A; p.P323T; 12:91104215-91104215	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.967C>A; p.P323T; 12:91104215-91104215	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.255C>T; p.A85A; 12:91108725-91108725	skin	malignant_melanoma	Substitution - coding silent
c.517G>A; p.E173K; 12:91108463-91108463	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.122G>A; p.C41Y; 12:91108858-91108858	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.539T>G; p.F180C; 12:91108441-91108441	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.602C>G; p.S201C; 12:91108378-91108378	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.749C>A; p.S250Y; 12:91108231-91108231	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.749C>A; p.S250Y; 12:91108231-91108231	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.594A>T; p.R198S; 12:91108386-91108386	central_nervous_system; brain	glioma	Substitution - Missense
c.337T>A; p.S113T; 12:91108643-91108643	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.558C>T; p.L186L; 12:91108422-91108422	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.161A>G; p.D54G; 12:91108819-91108819	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.76C>T; p.P26S; 12:91108904-91108904	skin	malignant_melanoma	Substitution - Missense
c.778G>A; p.D260N; 12:91108202-91108202	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.260A>T; p.E87V; 12:91108720-91108720	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.511C>A; p.L171M; 12:91108469-91108469	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.559G>A; p.E187K; 12:91108421-91108421	skin	malignant_melanoma	Substitution - Missense
c.559G>A; p.E187K; 12:91108421-91108421	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.718G>A; p.E240K; 12:91108262-91108262	skin	malignant_melanoma	Substitution - Missense
c.718G>A; p.E240K; 12:91108262-91108262	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.718G>A; p.E240K; 12:91108262-91108262	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.718G>A; p.E240K; 12:91108262-91108262	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.718G>A; p.E240K; 12:91108262-91108262	skin	malignant_melanoma	Substitution - Missense
c.421G>A; p.D141N; 12:91108559-91108559	skin	malignant_melanoma	Substitution - Missense
c.718G>A; p.E240K; 12:91108262-91108262	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.718G>A; p.E240K; 12:91108262-91108262	breast	carcinoma	Substitution - Missense
c.718G>A; p.E240K; 12:91108262-91108262	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.718G>A; p.E240K; 12:91108262-91108262	skin; mucosal	malignant_melanoma	Substitution - Missense
c.718G>A; p.E240K; 12:91108262-91108262	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.383T>C; p.L128P; 12:91108597-91108597	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.944G>T; p.R315L; 12:91104238-91104238	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.441C>T; p.N147N; 12:91108539-91108539	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.441C>T; p.N147N; 12:91108539-91108539	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.929G>T; p.R310L; 12:91104253-91104253	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.929G>T; p.R310L; 12:91104253-91104253	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.915G>T; p.K305N; 12:91104267-91104267	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.412T>A; p.S138T; 12:91108568-91108568	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.301C>T; p.L101F; 12:91108679-91108679	skin	malignant_melanoma	Substitution - Missense
c.573G>A; p.L191L; 12:91108407-91108407	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.250A>G; p.K84E; 12:91108730-91108730	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.615C>T; p.V205V; 12:91108365-91108365	skin	malignant_melanoma	Substitution - coding silent
c.749C>G; p.S250C; 12:91108231-91108231	breast	carcinoma	Substitution - Missense
c.861G>T; p.E287D; 12:91108119-91108119	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.725C>T; p.A242V; 12:91108255-91108255	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.382C>A; p.L128M; 12:91108598-91108598	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.517G>T; p.E173*; 12:91108463-91108463	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.12T>C; p.S4S; 12:91108968-91108968	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.944G>A; p.R315H; 12:91104238-91104238	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.944G>A; p.R315H; 12:91104238-91104238	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.944G>A; p.R315H; 12:91104238-91104238	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.944G>A; p.R315H; 12:91104238-91104238	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.222G>A; p.R74R; 12:91108758-91108758	skin	malignant_melanoma	Substitution - coding silent
c.617C>A; p.S206Y; 12:91108363-91108363	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.634T>G; p.L212V; 12:91108346-91108346	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.345G>T; p.L115F; 12:91108635-91108635	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.184C>A; p.P62T; 12:91108796-91108796	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.575G>A; p.S192N; 12:91108405-91108405	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.733G>A; p.G245R; 12:91108247-91108247	skin	malignant_melanoma	Substitution - Missense
c.174G>A; p.L58L; 12:91108806-91108806	skin	malignant_melanoma	Substitution - coding silent
c.535G>A; p.A179T; 12:91108445-91108445	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.583C>A; p.Q195K; 12:91108397-91108397	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.989G>A; p.R330H; 12:91104193-91104193	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.989G>A; p.R330H; 12:91104193-91104193	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.839A>G; p.Y280C; 12:91108141-91108141	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.389_390delAG; p.E130fs*17; 12:91108590-91108591	bone	osteosarcoma	Deletion - Frameshift
c.70G>A; p.D24N; 12:91108910-91108910	skin	malignant_melanoma	Substitution - Missense
c.507T>C; p.N169N; 12:91108473-91108473	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.988C>T; p.R330C; 12:91104194-91104194	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.988C>T; p.R330C; 12:91104194-91104194	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.988C>T; p.R330C; 12:91104194-91104194	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.988C>T; p.R330C; 12:91104194-91104194	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.641A>G; p.N214S; 12:91108339-91108339	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.583C>T; p.Q195*; 12:91108397-91108397	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.575G>C; p.S192T; 12:91108405-91108405	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.31G>A; p.A11T; 12:91108949-91108949	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.703C>T; p.R235C; 12:91108277-91108277	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.977A>T; p.Y326F; 12:91104205-91104205	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.977A>T; p.Y326F; 12:91104205-91104205	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.703C>T; p.R235C; 12:91108277-91108277	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.784T>C; p.S262P; 12:91108196-91108196	large_intestine; colon	NS	Substitution - Missense
c.36G>A; p.L12L; 12:91108944-91108944	skin	malignant_melanoma	Substitution - coding silent
c.36G>A; p.L12L; 12:91108944-91108944	skin	malignant_melanoma	Substitution - coding silent
c.699T>A; p.Y233*; 12:91108281-91108281	liver	carcinoma	Substitution - Nonsense
c.699T>A; p.Y233*; 12:91108281-91108281	liver	carcinoma	Substitution - Nonsense
c.217C>T; p.L73F; 12:91108763-91108763	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.547C>T; p.L183F; 12:91108433-91108433	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.294T>C; p.D98D; 12:91108686-91108686	stomach	adenocarcinoma	Substitution - coding silent
c.413C>A; p.S138Y; 12:91108567-91108567	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.115C>G; p.P39A; 12:91108865-91108865	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.334T>C; p.F112L; 12:91108646-91108646	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.336C>A; p.F112L; 12:91108644-91108644	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.334T>C; p.F112L; 12:91108646-91108646	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.661C>G; p.P221A; 12:91108319-91108319	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.683T>C; p.F228S; 12:91108297-91108297	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.493C>A; p.H165N; 12:91108487-91108487	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.460T>A; p.S154T; 12:91108520-91108520	liver	carcinoma	Substitution - Missense
c.1000G>A; p.E334K; 12:91104182-91104182	skin	malignant_melanoma	Substitution - Missense
c.905C>T; p.S302F; 12:91104277-91104277	skin	malignant_melanoma	Substitution - Missense
c.743G>A; p.G248E; 12:91108237-91108237	skin	malignant_melanoma	Substitution - Missense
c.697T>A; p.Y233N; 12:91108283-91108283	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.743G>A; p.G248E; 12:91108237-91108237	skin	malignant_melanoma	Substitution - Missense
c.743G>A; p.G248E; 12:91108237-91108237	skin	malignant_melanoma	Substitution - Missense
c.397G>C; p.G133R; 12:91108583-91108583	breast	carcinoma	Substitution - Missense
c.891C>T; p.I297I; 12:91104291-91104291	skin	malignant_melanoma	Substitution - coding silent
c.509G>T; p.R170L; 12:91108471-91108471	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.764C>T; p.S255F; 12:91108216-91108216	skin	malignant_melanoma	Substitution - Missense
c.617C>T; p.S206F; 12:91108363-91108363	skin	malignant_melanoma	Substitution - Missense
c.336C>T; p.F112F; 12:91108644-91108644	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.718G>T; p.E240*; 12:91108262-91108262	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.929G>A; p.R310H; 12:91104253-91104253	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.634T>C; p.L212L; 12:91108346-91108346	skin	malignant_melanoma	Substitution - coding silent
c.335T>C; p.F112S; 12:91108645-91108645	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.968C>T; p.P323L; 12:91104214-91104214	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.585G>C; p.Q195H; 12:91108395-91108395	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.510G>A; p.R170R; 12:91108470-91108470	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.64G>C; p.D22H; 12:91108916-91108916	kidney	carcinoma; renal_cell_carcinoma	Substitution - Missense
c.274C>A; p.L92M; 12:91108706-91108706	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.378C>G; p.N126K; 12:91108602-91108602	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.508C>A; p.R170R; 12:91108472-91108472	large_intestine; colon	NS	Substitution - coding silent
c.60C>G; p.Y20*; 12:91108920-91108920	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.918C>T; p.I306I; 12:91104264-91104264	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation