lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4046
Symbol	LSP1
Synonymous	WP34\|pp52
Full name	lymphocyte-specific protein 1
Gene description	47 kDa actin binding protein\|47 kDa actin-binding protein\|52 kDa phosphoprotein\|F-actin binding and cytoskeleton associated protein\|leufactin (leukocyte F-actin binding protein)\|leukocyte-specific protein 1\|lymphocyte-specific antigen WP34
Cytoband	11p15.5
Gene type	protein-coding
Synonymous	MIM:153432; HGNC:HGNC:6707; Ensembl:ENSG00000130592; HPRD:01083; Vega:OTTHUMG00000012252

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.834G>T; p.*278Y; 11:1887563-1887563	large_intestine; colon	carcinoma; adenocarcinoma	Nonstop extension
c.830C>A; p.P277H; 11:1887559-1887559	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.825G>A; p.P275P; 11:1887554-1887554	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.825G>A; p.P275P; 11:1887554-1887554	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.801G>A; p.E267E; 11:1887530-1887530	skin	malignant_melanoma	Substitution - coding silent
c.682G>T; p.D228Y; 11:1887252-1887252	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.773T>A; p.F258Y; 11:1887502-1887502	pancreas	carcinoma	Substitution - Missense
c.392delG; p.S131fs*13; 11:1884011-1884011	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.625G>A; p.E209K; 11:1886825-1886825	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.129G>A; p.E43E; 11:1881555-1881555	kidney	other; neoplasm	Substitution - coding silent
c.535G>T; p.A179S; 11:1886735-1886735	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.440T>C; p.I147T; 11:1884314-1884314	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.336G>A; p.R112R; 11:1883955-1883955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.433C>T; p.R145C; 11:1884307-1884307	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.805G>T; p.V269L; 11:1887534-1887534	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.475G>T; p.D159Y; 11:1884525-1884525	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.826G>T; p.A276S; 11:1887555-1887555	lung; left_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.564G>T; p.Q188H; 11:1886764-1886764	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.596C>T; p.A199V; 11:1886796-1886796	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.370G>A; p.E124K; 11:1883989-1883989	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.416G>A; p.R139K; 11:1884290-1884290	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.74G>A; p.R25K; 11:1881500-1881500	oesophagus	carcinoma	Substitution - Missense
c.270G>C; p.Q90H; 11:1883518-1883518	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.799G>A; p.E267K; 11:1887528-1887528	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.189C>T; p.Y63Y; 11:1883437-1883437	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.657G>A; p.P219P; 11:1886857-1886857	pancreas	carcinoma	Substitution - coding silent
c.560G>A; p.R187H; 11:1886760-1886760	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.217C>A; p.L73M; 11:1883465-1883465	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.799G>T; p.E267*; 11:1887528-1887528	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.104C>T; p.A35V; 11:1881530-1881530	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.123C>T; p.S41S; 11:1881549-1881549	pancreas	carcinoma	Substitution - coding silent
c.420C>T; p.T140T; 11:1884294-1884294	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.462G>C; p.K154N; 11:1884512-1884512	urinary_tract; bladder	carcinoma	Substitution - Missense
c.337A>C; p.T113P; 11:1883956-1883956	liver	carcinoma	Substitution - Missense
c.208G>A; p.E70K; 11:1883456-1883456	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.208G>A; p.E70K; 11:1883456-1883456	urinary_tract; bladder	carcinoma	Substitution - Missense
c.540C>T; p.G180G; 11:1886740-1886740	thyroid	carcinoma	Substitution - coding silent
c.94C>T; p.H32Y; 11:1881520-1881520	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.371A>G; p.E124G; 11:1883990-1883990	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.176G>A; p.G59D; 11:1883424-1883424	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.559C>T; p.R187C; 11:1886759-1886759	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.40G>T; p.D14Y; 11:1881466-1881466	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.651G>T; p.K217N; 11:1886851-1886851	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.342C>A; p.P114P; 11:1883961-1883961	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.179T>A; p.L60Q; 11:1883427-1883427	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.787C>T; p.H263Y; 11:1887516-1887516	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.611G>A; p.R204Q; 11:1886811-1886811	pancreas	carcinoma	Substitution - Missense
c.534C>T; p.T178T; 11:1886734-1886734	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.777G>T; p.V259V; 11:1887506-1887506	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.777G>T; p.V259V; 11:1887506-1887506	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.425C>A; p.S142Y; 11:1884299-1884299	breast	carcinoma	Substitution - Missense
c.112G>A; p.A38T; 11:1881538-1881538	thyroid	other; neoplasm	Substitution - Missense
c.621G>A; p.T207T; 11:1886821-1886821	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.556G>A; p.A186T; 11:1886756-1886756	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.645G>A; p.A215A; 11:1886845-1886845	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.130delC; p.Q46fs*31; 11:1881556-1881556	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.130delC; p.Q46fs*31; 11:1881556-1881556	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.368T>A; p.I123N; 11:1883987-1883987	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.317A>G; p.Q106R; 11:1883936-1883936	liver	carcinoma	Substitution - Missense
c.317A>G; p.Q106R; 11:1883936-1883936	liver	carcinoma	Substitution - Missense
c.228G>A; p.L76L; 11:1883476-1883476	breast	carcinoma	Substitution - coding silent
c.190G>A; p.E64K; 11:1883438-1883438	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.792G>A; p.G264G; 11:1887521-1887521	skin	malignant_melanoma	Substitution - coding silent
c.612G>T; p.R204R; 11:1886812-1886812	kidney	other; neoplasm	Substitution - coding silent
c.526A>G; p.I176V; 11:1884576-1884576	pancreas	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation