lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4033
Symbol	LRMP
Synonymous	JAW1
Full name	lymphoid-restricted membrane protein
Gene description	protein Jaw1
Cytoband	12p12.1
Gene type	protein-coding
Synonymous	MIM:602003; HGNC:HGNC:6690; Ensembl:ENSG00000118308; HPRD:03593; Vega:OTTHUMG00000170192

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.874C>T; p.P292S; 12:25101310-25101310	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1034G>A; p.R345K; 12:25104046-25104046	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1258T>A; p.Y420N; 12:25107818-25107818	liver	carcinoma	Substitution - Missense
c.1486C>T; p.P496S; 12:25108046-25108046	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1258T>A; p.Y420N; 12:25107818-25107818	liver	carcinoma	Substitution - Missense
c.1210C>T; p.L404F; 12:25107004-25107004	skin	malignant_melanoma	Substitution - Missense
c.705G>A; p.V235V; 12:25097008-25097008	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.546C>T; p.S182S; 12:25090137-25090137	skin	malignant_melanoma	Substitution - coding silent
c.471A>G; p.E157E; 12:25090062-25090062	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1437G>A; p.T479T; 12:25107997-25107997	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.282C>A; p.D94E; 12:25083460-25083460	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1061C>G; p.S354*; 12:25104375-25104375	ovary	carcinoma; serous_carcinoma	Substitution - Nonsense
c.480A>T; p.R160S; 12:25090071-25090071	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.441T>C; p.T147T; 12:25089766-25089766	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.124A>G; p.I42V; 12:25079450-25079450	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.124A>G; p.I42V; 12:25079450-25079450	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.969A>G; p.L323L; 12:25103872-25103872	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1379G>A; p.G460D; 12:25107939-25107939	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.590G>C; p.C197S; 12:25090181-25090181	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.832G>T; p.E278*; 12:25101268-25101268	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1282A>G; p.T428A; 12:25107842-25107842	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.243A>G; p.Q81Q; 12:25079762-25079762	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.548G>A; p.R183H; 12:25090139-25090139	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1149-1G>T; p.?; 12:25106942-25106942	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.485C>T; p.S162F; 12:25090076-25090076	skin	malignant_melanoma	Substitution - Missense
c.784G>A; p.V262I; 12:25101220-25101220	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1204C>T; p.P402S; 12:25106998-25106998	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.242A>G; p.Q81R; 12:25079761-25079761	liver	carcinoma	Substitution - Missense
c.242A>G; p.Q81R; 12:25079761-25079761	liver	carcinoma	Substitution - Missense
c.728G>A; p.G243E; 12:25097031-25097031	skin	malignant_melanoma	Substitution - Missense
c.389C>T; p.P130L; 12:25089629-25089629	skin	malignant_melanoma	Substitution - Missense
c.701G>A; p.R234Q; 12:25097004-25097004	skin	malignant_melanoma	Substitution - Missense
c.728G>A; p.G243E; 12:25097031-25097031	skin	malignant_melanoma	Substitution - Missense
c.39A>G; p.E13E; 12:25079258-25079258	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.475C>A; p.L159I; 12:25090066-25090066	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.73G>A; p.E25K; 12:25079399-25079399	skin; upper_back	malignant_melanoma	Substitution - Missense
c.932A>G; p.K311R; 12:25102240-25102240	skin	malignant_melanoma	Substitution - Missense
c.1008G>A; p.M336I; 12:25104020-25104020	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.231G>A; p.T77T; 12:25079750-25079750	skin	malignant_melanoma	Substitution - coding silent
c.231G>A; p.T77T; 12:25079750-25079750	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1141G>A; p.E381K; 12:25104455-25104455	skin	malignant_melanoma	Substitution - Missense
c.155T>A; p.L52Q; 12:25079674-25079674	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.106T>G; p.S36A; 12:25079432-25079432	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.78T>G; p.Y26*; 12:25079404-25079404	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.787G>A; p.E263K; 12:25101223-25101223	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1054T>C; p.L352L; 12:25104368-25104368	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.926A>T; p.N309I; 12:25102234-25102234	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.506G>T; p.W169L; 12:25090097-25090097	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.343G>A; p.E115K; 12:25088127-25088127	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.950G>A; p.R317K; 12:25103853-25103853	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.946C>T; p.R316*; 12:25103849-25103849	pancreas	carcinoma	Substitution - Nonsense
c.946C>T; p.R316*; 12:25103849-25103849	pancreas	carcinoma	Substitution - Nonsense
c.946C>T; p.R316*; 12:25103849-25103849	pancreas	carcinoma	Substitution - Nonsense
c.245G>A; p.G82D; 12:25083423-25083423	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.126A>G; p.I42M; 12:25079452-25079452	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.371G>A; p.G124E; 12:25088155-25088155	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1425G>A; p.E475E; 12:25107985-25107985	skin	malignant_melanoma	Substitution - coding silent
c.886G>A; p.D296N; 12:25101322-25101322	skin	malignant_melanoma	Substitution - Missense
c.582C>T; p.I194I; 12:25090173-25090173	skin	malignant_melanoma	Substitution - coding silent
c.1172C>T; p.S391F; 12:25106966-25106966	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1048C>T; p.R350C; 12:25104362-25104362	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1261G>T; p.D421Y; 12:25107821-25107821	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1021C>T; p.R341*; 12:25104033-25104033	skin	malignant_melanoma	Substitution - Nonsense
c.844G>T; p.V282F; 12:25101280-25101280	breast	carcinoma	Substitution - Missense
c.496A>T; p.K166*; 12:25090087-25090087	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.932A>T; p.K311M; 12:25102240-25102240	stomach	adenocarcinoma	Substitution - Missense
c.42C>T; p.R14R; 12:25079261-25079261	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.72G>A; p.R24R; 12:25079398-25079398	skin	malignant_melanoma	Substitution - coding silent
c.247A>G; p.T83A; 12:25083425-25083425	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1452C>A; p.I484I; 12:25108012-25108012	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.310A>C; p.N104H; 12:25083488-25083488	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1338A>C; p.A446A; 12:25107898-25107898	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.555G>T; p.L185F; 12:25090146-25090146	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1033A>G; p.R345G; 12:25104045-25104045	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1434G>C; p.W478C; 12:25107994-25107994	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.811A>G; p.K271E; 12:25101247-25101247	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1033A>G; p.R345G; 12:25104045-25104045	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1417C>T; p.Q473*; 12:25107977-25107977	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1322T>C; p.L441P; 12:25107882-25107882	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.325G>A; p.E109K; 12:25088109-25088109	skin	malignant_melanoma	Substitution - Missense
c.18T>A; p.S6R; 12:25069425-25069425	thyroid	other; neoplasm	Substitution - Missense
c.1177G>A; p.E393K; 12:25106971-25106971	skin	malignant_melanoma	Substitution - Missense
c.421C>G; p.L141V; 12:25089661-25089661	thyroid	other; neoplasm	Substitution - Missense
c.110C>T; p.S37L; 12:25079436-25079436	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.110C>T; p.S37L; 12:25079436-25079436	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.444T>A; p.S148S; 12:25089769-25089769	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.1362G>C; p.L454F; 12:25107922-25107922	urinary_tract; bladder	carcinoma	Substitution - Missense
c.429A>T; p.Q143H; 12:25089669-25089669	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1255G>A; p.V419I; 12:25107049-25107049	skin	malignant_melanoma	Substitution - Missense
c.1156G>A; p.D386N; 12:25106950-25106950	skin	malignant_melanoma	Substitution - Missense
c.1402G>A; p.D468N; 12:25107962-25107962	pancreas	carcinoma	Substitution - Missense
c.259C>A; p.H87N; 12:25083437-25083437	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1231C>A; p.P411T; 12:25107025-25107025	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.800G>A; p.R267K; 12:25101236-25101236	skin	malignant_melanoma	Substitution - Missense
c.1146A>G; p.L382L; 12:25104460-25104460	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.318A>G; p.E106E; 12:25088102-25088102	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1319_1320CC>TT; p.A440V; 12:25107879-25107880	skin; neck	malignant_melanoma	Substitution - Missense
c.230C>T; p.T77M; 12:25079749-25079749	pancreas	carcinoma	Substitution - Missense
c.479G>T; p.R160I; 12:25090070-25090070	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1030A>G; p.R344G; 12:25104042-25104042	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1008G>C; p.M336I; 12:25104020-25104020	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.43G>A; p.V15M; 12:25079262-25079262	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.202G>A; p.E68K; 12:25079721-25079721	liver	carcinoma	Substitution - Missense
c.207G>A; p.E69E; 12:25079726-25079726	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.570G>A; p.L190L; 12:25090161-25090161	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.206A>T; p.E69V; 12:25079725-25079725	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1479C>G; p.H493Q; 12:25108039-25108039	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.25G>A; p.E9K; 12:25079244-25079244	skin	malignant_melanoma	Substitution - Missense
c.185A>T; p.N62I; 12:25079704-25079704	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation