lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4023
Symbol	LPL
Synonymous	HDLCQ11\|LIPD
Full name	lipoprotein lipase
Gene description	-
Cytoband	8p22
Gene type	protein-coding
Synonymous	MIM:609708; HGNC:HGNC:6677; Ensembl:ENSG00000175445; HPRD:01999; Vega:OTTHUMG00000036645

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.73G>A; p.V25M; 8:19939513-19939513	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.237C>T; p.I79I; 8:19948328-19948328	skin	malignant_melanoma	Substitution - coding silent
c.111C>T; p.I37I; 8:19948202-19948202	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1193A>G; p.D398G; 8:19960954-19960954	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.339G>A; p.W113*; 8:19951858-19951858	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.913T>C; p.C305R; 8:19955978-19955978	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1423G>T; p.G475C; 8:19962215-19962215	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.125C>T; p.A42V; 8:19948216-19948216	skin	malignant_melanoma	Substitution - Missense
c.894G>T; p.E298D; 8:19955959-19955959	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.125C>T; p.A42V; 8:19948216-19948216	skin	malignant_melanoma	Substitution - Missense
c.421T>C; p.W141R; 8:19951940-19951940	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.892G>C; p.E298Q; 8:19955957-19955957	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.892G>C; p.E298Q; 8:19955957-19955957	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.60C>A; p.A20A; 8:19939500-19939500	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.621C>T; p.D207D; 8:19954199-19954199	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.783C>A; p.D261E; 8:19955848-19955848	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.168C>G; p.L56L; 8:19948259-19948259	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.57C>T; p.T19T; 8:19939497-19939497	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.921G>T; p.K307N; 8:19955986-19955986	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.921G>T; p.K307N; 8:19955986-19955986	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1342G>A; p.E448K; 8:19962134-19962134	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.775+1G>A; p.?; 8:19954354-19954354	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.1018+2T>C; p.?; 8:19956085-19956085	oesophagus; lower_third	carcinoma; adenocarcinoma	Unknown
c.256G>T; p.G86*; 8:19951775-19951775	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.743C>T; p.A248V; 8:19954321-19954321	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.217A>T; p.S73C; 8:19948308-19948308	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.751G>A; p.V251M; 8:19954329-19954329	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.54G>A; p.L18L; 8:19939494-19939494	breast	carcinoma	Substitution - coding silent
c.1213T>G; p.L405V; 8:19960974-19960974	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.409C>T; p.R137W; 8:19951928-19951928	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.405G>A; p.V135V; 8:19951924-19951924	thyroid	other; neoplasm	Substitution - coding silent
c.290C>T; p.A97V; 8:19951809-19951809	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.290C>T; p.A97V; 8:19951809-19951809	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1059G>C; p.E353D; 8:19959300-19959300	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.277C>T; p.P93S; 8:19951796-19951796	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1351T>C; p.S451P; 8:19962143-19962143	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.297G>A; p.L99L; 8:19951816-19951816	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.767G>C; p.G256A; 8:19954345-19954345	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.106G>A; p.D36N; 8:19948197-19948197	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.397C>A; p.Q133K; 8:19951916-19951916	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.941G>A; p.G314D; 8:19956006-19956006	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.768A>G; p.G256G; 8:19954346-19954346	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.135C>A; p.T45T; 8:19948226-19948226	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.768A>G; p.G256G; 8:19954346-19954346	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.768A>G; p.G256G; 8:19954346-19954346	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1186G>C; p.E396Q; 8:19960947-19960947	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.768A>G; p.G256G; 8:19954346-19954346	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.458T>C; p.V153A; 8:19953338-19953338	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.792G>T; p.V264V; 8:19955857-19955857	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.353A>T; p.Q118L; 8:19951872-19951872	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.38T>A; p.V13E; 8:19939478-19939478	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.30T>C; p.T10T; 8:19939470-19939470	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.112G>A; p.E38K; 8:19948203-19948203	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.112G>A; p.E38K; 8:19948203-19948203	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.112G>A; p.E38K; 8:19948203-19948203	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.112G>A; p.E38K; 8:19948203-19948203	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1188G>T; p.E396D; 8:19960949-19960949	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.56C>A; p.T19N; 8:19939496-19939496	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1061G>C; p.S354T; 8:19959302-19959302	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.718C>T; p.Q240*; 8:19954296-19954296	pancreas	NS	Substitution - Nonsense
c.303G>T; p.K101N; 8:19951822-19951822	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.303G>T; p.K101N; 8:19951822-19951822	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1326G>C; p.V442V; 8:19962118-19962118	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.1326G>C; p.V442V; 8:19962118-19962118	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1221C>G; p.L407L; 8:19960982-19960982	breast	carcinoma	Substitution - coding silent
c.590G>A; p.R197H; 8:19954168-19954168	pleura	pulmonary_blastoma	Substitution - Missense
c.15C>A; p.A5A; 8:19939455-19939455	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.278C>A; p.P93Q; 8:19951797-19951797	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.1427+6C>A; p.?; 8:19962225-19962225	pancreas	carcinoma	Unknown
c.526G>A; p.V176I; 8:19953406-19953406	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.559C>T; p.P187S; 8:19954137-19954137	thyroid	carcinoma	Substitution - Missense
c.440A>C; p.N147T; 8:19953320-19953320	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.142G>T; p.D48Y; 8:19948233-19948233	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.551C>T; p.P184L; 8:19954129-19954129	urinary_tract; bladder	carcinoma	Substitution - Missense
c.375G>A; p.A125A; 8:19951894-19951894	prostate	carcinoma	Substitution - coding silent
c.521A>C; p.K174T; 8:19953401-19953401	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.521A>C; p.K174T; 8:19953401-19953401	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1276T>C; p.F426L; 8:19961037-19961037	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1405T>C; p.S469P; 8:19962197-19962197	liver	carcinoma	Substitution - Missense
c.1405T>C; p.S469P; 8:19962197-19962197	liver	carcinoma	Substitution - Missense
c.1151C>T; p.S384F; 8:19960912-19960912	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1272C>A; p.P424P; 8:19961033-19961033	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.613T>G; p.F205V; 8:19954191-19954191	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.248C>A; p.T83K; 8:19948339-19948339	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.307G>T; p.E103*; 8:19951826-19951826	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.508A>C; p.S170R; 8:19953388-19953388	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.293C>T; p.A98V; 8:19951812-19951812	liver	carcinoma	Substitution - Missense
c.642A>C; p.R214S; 8:19954220-19954220	central_nervous_system; brain	glioma	Substitution - Missense
c.293C>T; p.A98V; 8:19951812-19951812	liver	carcinoma	Substitution - Missense
c.429+9G>T; p.?; 8:19951957-19951957	skin; leg	malignant_melanoma; nodular	Unknown
c.702G>A; p.P234P; 8:19954280-19954280	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.279delA; p.K94fs*78; 8:19951798-19951798	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1043A>C; p.H348P; 8:19959284-19959284	skin	malignant_melanoma	Substitution - Missense
c.688G>T; p.V230F; 8:19954266-19954266	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.582C>A; p.A194A; 8:19954160-19954160	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.757G>A; p.A253T; 8:19954335-19954335	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.584C>T; p.P195L; 8:19954162-19954162	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.372C>T; p.S124S; 8:19951891-19951891	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1209C>G; p.L403L; 8:19960970-19960970	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.175G>A; p.G59R; 8:19948266-19948266	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.175G>A; p.G59R; 8:19948266-19948266	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.789A>G; p.L263L; 8:19955854-19955854	liver	carcinoma	Substitution - coding silent
c.1263G>A; p.W421*; 8:19961024-19961024	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1263G>A; p.W421*; 8:19961024-19961024	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Nonsense
c.1233T>C; p.S411S; 8:19960994-19960994	liver	carcinoma	Substitution - coding silent
c.1233T>C; p.S411S; 8:19960994-19960994	liver	carcinoma	Substitution - coding silent
c.1324G>A; p.V442M; 8:19962116-19962116	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.36C>A; p.A12A; 8:19939476-19939476	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.566T>A; p.F189Y; 8:19954144-19954144	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.146C>T; p.T49I; 8:19948237-19948237	breast	carcinoma	Substitution - Missense
c.1108G>A; p.V370M; 8:19959349-19959349	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.189C>T; p.S63S; 8:19948280-19948280	skin	malignant_melanoma	Substitution - coding silent
c.847G>A; p.E283K; 8:19955912-19955912	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1344G>T; p.E448D; 8:19962136-19962136	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1344G>T; p.E448D; 8:19962136-19962136	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.737G>A; p.G246E; 8:19954315-19954315	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.313G>C; p.D105H; 8:19951832-19951832	NS	NS	Substitution - Missense
c.547G>A; p.D183N; 8:19954125-19954125	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.767G>A; p.G256E; 8:19954345-19954345	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1290G>A; p.K430K; 8:19961051-19961051	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.250-9C>T; p.?; 8:19951760-19951760	pancreas	carcinoma	Unknown
c.748C>T; p.R250C; 8:19954326-19954326	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.662T>A; p.I221N; 8:19954240-19954240	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.282A>C; p.K94N; 8:19951801-19951801	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.647C>T; p.S216F; 8:19954225-19954225	liver	carcinoma	Substitution - Missense
c.647C>T; p.S216F; 8:19954225-19954225	liver	carcinoma	Substitution - Missense
c.1295G>A; p.R432K; 8:19961056-19961056	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1295G>A; p.R432K; 8:19961056-19961056	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.292G>A; p.A98T; 8:19951811-19951811	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.776-2A>G; p.?; 8:19955839-19955839	stomach	carcinoma; adenocarcinoma	Unknown
c.451G>A; p.D151N; 8:19953331-19953331	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1003C>G; p.Q335E; 8:19956068-19956068	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1170C>A; p.S390S; 8:19960931-19960931	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.828C>T; p.I276I; 8:19955893-19955893	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.346C>T; p.R116W; 8:19951865-19951865	large_intestine	adenoma	Substitution - Missense
c.656G>A; p.R219Q; 8:19954234-19954234	pancreas	carcinoma	Substitution - Missense
c.648C>T; p.S216S; 8:19954226-19954226	skin	malignant_melanoma	Substitution - coding silent
c.373G>A; p.A125T; 8:19951892-19951892	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.373G>A; p.A125T; 8:19951892-19951892	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.373G>A; p.A125T; 8:19951892-19951892	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1415A>G; p.K472R; 8:19962207-19962207	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.960C>T; p.V320V; 8:19956025-19956025	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.638C>T; p.T213I; 8:19954216-19954216	skin	malignant_melanoma	Substitution - Missense
c.1114G>A; p.E372K; 8:19959355-19959355	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation