lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	4016
Symbol	LOXL1
Synonymous	LOL\|LOXL
Full name	lysyl oxidase-like 1
Gene description	lysyl oxidase homolog 1\|lysyl oxidase-like protein 1
Cytoband	15q22
Gene type	protein-coding
Synonymous	MIM:153456; HGNC:HGNC:6665; Ensembl:ENSG00000129038; HPRD:08861; Vega:OTTHUMG00000137595

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1176C>T; p.S392S; 15:73942927-73942927	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1376G>A; p.S459N; 15:73947093-73947093	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.597C>G; p.D199E; 15:73927380-73927380	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.574G>T; p.D192Y; 15:73927357-73927357	pancreas	carcinoma; acinar_carcinoma	Substitution - Missense
c.458G>A; p.G153D; 15:73927241-73927241	thyroid	other; neoplasm	Substitution - Missense
c.458G>A; p.G153D; 15:73927241-73927241	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.458G>A; p.G153D; 15:73927241-73927241	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.458G>A; p.G153D; 15:73927241-73927241	thyroid	other; neoplasm	Substitution - Missense
c.458G>A; p.G153D; 15:73927241-73927241	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1542G>A; p.A514A; 15:73947842-73947842	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.1542G>A; p.A514A; 15:73947842-73947842	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.1388T>C; p.L463P; 15:73947105-73947105	breast	carcinoma	Substitution - Missense
c.1216G>T; p.A406S; 15:73946421-73946421	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.422G>T; p.R141L; 15:73927205-73927205	thyroid	other; neoplasm	Substitution - Missense
c.422G>T; p.R141L; 15:73927205-73927205	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.422G>T; p.R141L; 15:73927205-73927205	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.422G>T; p.R141L; 15:73927205-73927205	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.422G>T; p.R141L; 15:73927205-73927205	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.422G>T; p.R141L; 15:73927205-73927205	thyroid	other; neoplasm	Substitution - Missense
c.422G>T; p.R141L; 15:73927205-73927205	large_intestine; rectum	NS	Substitution - Missense
c.422G>T; p.R141L; 15:73927205-73927205	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1266C>T; p.F422F; 15:73946471-73946471	skin	malignant_melanoma	Substitution - coding silent
c.647C>G; p.A216G; 15:73927430-73927430	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1246G>T; p.V416L; 15:73946451-73946451	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1549G>A; p.D517N; 15:73947849-73947849	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1262G>A; p.R421H; 15:73946467-73946467	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1543G>A; p.D515N; 15:73947843-73947843	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1443C>T; p.C481C; 15:73947160-73947160	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.411G>C; p.T137T; 15:73927194-73927194	prostate	carcinoma	Substitution - coding silent
c.411G>C; p.T137T; 15:73927194-73927194	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1120C>T; p.P374S; 15:73942871-73942871	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1711A>C; p.I571L; 15:73949567-73949567	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.403G>T; p.D135Y; 15:73927186-73927186	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1506G>A; p.Q502Q; 15:73947223-73947223	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.579C>T; p.P193P; 15:73927362-73927362	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.579C>T; p.P193P; 15:73927362-73927362	skin	malignant_melanoma	Substitution - coding silent
c.1383C>T; p.Y461Y; 15:73947100-73947100	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1383C>T; p.Y461Y; 15:73947100-73947100	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1190C>T; p.A397V; 15:73942941-73942941	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1261C>T; p.R421C; 15:73946466-73946466	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.929A>C; p.Y310S; 15:73927712-73927712	pancreas	carcinoma	Substitution - Missense
c.1551C>T; p.D517D; 15:73947851-73947851	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1458C>A; p.T486T; 15:73947175-73947175	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1180C>T; p.R394C; 15:73942931-73942931	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1180C>T; p.R394C; 15:73942931-73942931	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1343G>A; p.C448Y; 15:73946548-73946548	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.1427A>G; p.H476R; 15:73947144-73947144	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1343G>A; p.C448Y; 15:73946548-73946548	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.476C>G; p.S159W; 15:73927259-73927259	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1684C>T; p.R562C; 15:73949540-73949540	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1684C>T; p.R562C; 15:73949540-73949540	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1684C>T; p.R562C; 15:73949540-73949540	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.208G>A; p.E70K; 15:73926991-73926991	liver	carcinoma	Substitution - Missense
c.208G>A; p.E70K; 15:73926991-73926991	liver	carcinoma	Substitution - Missense
c.1238A>T; p.D413V; 15:73946443-73946443	skin	malignant_melanoma	Substitution - Missense
c.592T>C; p.Y198H; 15:73927375-73927375	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.555C>T; p.V185V; 15:73927338-73927338	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1107C>T; p.L369L; 15:73942858-73942858	skin	malignant_melanoma	Substitution - coding silent
c.1177C>A; p.L393M; 15:73942928-73942928	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.638G>A; p.G213D; 15:73927421-73927421	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1533C>A; p.T511T; 15:73947833-73947833	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.661T>C; p.S221P; 15:73927444-73927444	ovary	other; neoplasm	Substitution - Missense
c.118C>T; p.R40W; 15:73926901-73926901	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1275C>T; p.R425R; 15:73946480-73946480	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1597C>T; p.L533F; 15:73947897-73947897	NS	malignant_melanoma	Substitution - Missense
c.1644C>T; p.F548F; 15:73949500-73949500	skin	malignant_melanoma	Substitution - coding silent
c.1066G>C; p.V356L; 15:73927849-73927849	thyroid	other; neoplasm	Substitution - Missense
c.1243G>A; p.D415N; 15:73946448-73946448	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1425delC; p.H476fs*29; 15:73947142-73947142	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - Frameshift
c.486C>T; p.A162A; 15:73927269-73927269	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.493A>G; p.S165G; 15:73927276-73927276	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1502C>T; p.T501I; 15:73947219-73947219	skin	malignant_melanoma	Substitution - Missense
c.1514G>A; p.S505N; 15:73947814-73947814	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1506+7C>T; p.?; 15:73947230-73947230	ovary	other; neoplasm	Unknown
c.1506+7C>T; p.?; 15:73947230-73947230	ovary	other; neoplasm	Unknown
c.1696G>A; p.A566T; 15:73949552-73949552	skin; trunk	malignant_melanoma	Substitution - Missense
c.420C>T; p.A140A; 15:73927203-73927203	skin	malignant_melanoma	Substitution - coding silent
c.1564G>A; p.D522N; 15:73947864-73947864	skin	malignant_melanoma	Substitution - Missense
c.1564G>A; p.D522N; 15:73947864-73947864	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.677A>C; p.Y226S; 15:73927460-73927460	ovary	other; neoplasm	Substitution - Missense
c.1398A>T; p.A466A; 15:73947115-73947115	kidney	other; neoplasm	Substitution - coding silent
c.1113C>T; p.D371D; 15:73942864-73942864	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1573G>A; p.D525N; 15:73947873-73947873	stomach	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation