lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3984
Symbol	LIMK1
Synonymous	LIMK\|LIMK-1
Full name	LIM domain kinase 1
Gene description	LIM motif-containing protein kinase
Cytoband	7q11.23
Gene type	protein-coding
Synonymous	MIM:601329; HGNC:HGNC:6613; Ensembl:ENSG00000106683; HPRD:03210; Vega:OTTHUMG00000023448

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.92G>T; p.R31M; 7:74085784-74085784	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1911C>T; p.S637S; 7:74121268-74121268	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1829A>C; p.H610P; 7:74121186-74121186	breast	carcinoma	Substitution - Missense
c.794G>T; p.G265V; 7:74106156-74106156	breast	carcinoma	Substitution - Missense
c.1123G>A; p.E375K; 7:74107928-74107928	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1381C>T; p.L461F; 7:74111969-74111969	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.338C>T; p.T113M; 7:74097126-74097126	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1538C>T; p.P513L; 7:74115929-74115929	skin	malignant_melanoma	Substitution - Missense
c.1538C>T; p.P513L; 7:74115929-74115929	skin	malignant_melanoma	Substitution - Missense
c.1709A>C; p.Y570S; 7:74120977-74120977	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1709A>C; p.Y570S; 7:74120977-74120977	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1538C>T; p.P513L; 7:74115929-74115929	skin	malignant_melanoma	Substitution - Missense
c.358G>A; p.D120N; 7:74097146-74097146	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.664C>A; p.R222R; 7:74105930-74105930	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1567G>A; p.G523S; 7:74115958-74115958	breast	carcinoma	Substitution - Missense
c.1197C>T; p.F399F; 7:74108949-74108949	skin	malignant_melanoma	Substitution - coding silent
c.1260G>A; p.T420T; 7:74109012-74109012	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1809G>A; p.W603*; 7:74121166-74121166	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.786G>A; p.L262L; 7:74106148-74106148	skin	malignant_melanoma	Substitution - coding silent
c.1773C>T; p.P591P; 7:74121041-74121041	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1633C>T; p.R545W; 7:74120901-74120901	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1633C>T; p.R545W; 7:74120901-74120901	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.470C>T; p.S157F; 7:74099100-74099100	urinary_tract; bladder	carcinoma	Substitution - Missense
c.486C>A; p.T162T; 7:74099116-74099116	skin	malignant_melanoma	Substitution - coding silent
c.360C>T; p.D120D; 7:74097148-74097148	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.231G>T; p.W77C; 7:74096700-74096700	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.527G>A; p.R176H; 7:74099157-74099157	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.276C>G; p.T92T; 7:74096745-74096745	oesophagus	carcinoma	Substitution - coding silent
c.155G>A; p.C52Y; 7:74096624-74096624	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.548_549insC; p.H186fs*55; 7:74099178-74099179	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.712G>A; p.E238K; 7:74105978-74105978	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.712G>A; p.E238K; 7:74105978-74105978	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.712G>A; p.E238K; 7:74105978-74105978	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.491C>T; p.T164I; 7:74099121-74099121	skin	malignant_melanoma	Substitution - Missense
c.691A>G; p.I231V; 7:74105957-74105957	central_nervous_system; brain	glioma	Substitution - Missense
c.1166G>A; p.R389Q; 7:74108918-74108918	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1730C>T; p.P577L; 7:74120998-74120998	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1536delC; p.Y514fs*7; 7:74115927-74115927	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1448G>A; p.R483H; 7:74115839-74115839	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.159T>C; p.C53C; 7:74096628-74096628	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1591G>T; p.D531Y; 7:74120606-74120606	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1615C>A; p.L539M; 7:74120630-74120630	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.402C>T; p.C134C; 7:74099032-74099032	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.495G>A; p.L165L; 7:74099125-74099125	skin	malignant_melanoma	Substitution - coding silent
c.402C>T; p.C134C; 7:74099032-74099032	prostate	carcinoma	Substitution - coding silent
c.292-8C>T; p.?; 7:74097072-74097072	large_intestine; colon	adenoma	Unknown
c.220_222delAAG; p.K74del; 7:74096689-74096691	stomach	carcinoma; adenocarcinoma	Deletion - In frame
c.220_222delAAG; p.K74del; 7:74096689-74096691	stomach	carcinoma; adenocarcinoma	Deletion - In frame
c.497T>G; p.V166G; 7:74099127-74099127	skin	malignant_melanoma	Substitution - Missense
c.1906G>A; p.E636K; 7:74121263-74121263	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1779G>A; p.K593K; 7:74121047-74121047	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.969C>T; p.S323S; 7:74107097-74107097	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1632G>A; p.G544G; 7:74120900-74120900	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.1624A>C; p.I542L; 7:74120892-74120892	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.858C>G; p.S286R; 7:74106220-74106220	breast	carcinoma	Substitution - Missense
c.1025G>A; p.G342E; 7:74107153-74107153	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.620G>A; p.G207D; 7:74105886-74105886	stomach	carcinoma	Substitution - Missense
c.1103A>C; p.K368T; 7:74107908-74107908	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1462G>A; p.E488K; 7:74115853-74115853	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1446G>A; p.A482A; 7:74115837-74115837	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1762G>A; p.D588N; 7:74121030-74121030	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1582G>A; p.E528K; 7:74120597-74120597	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.529G>A; p.G177R; 7:74099159-74099159	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1663C>T; p.R555C; 7:74120931-74120931	skin	malignant_melanoma	Substitution - Missense
c.1460A>G; p.D487G; 7:74115851-74115851	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1901G>A; p.R634H; 7:74121258-74121258	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.263C>G; p.S88C; 7:74096732-74096732	central_nervous_system; brain	glioma	Substitution - Missense
c.361G>A; p.G121R; 7:74097149-74097149	liver	carcinoma	Substitution - Missense
c.19T>G; p.C7G; 7:74084009-74084009	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1774G>A; p.E592K; 7:74121042-74121042	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1023C>T; p.H341H; 7:74107151-74107151	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.319G>A; p.E107K; 7:74097107-74097107	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.865C>A; p.R289R; 7:74106227-74106227	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1587G>A; p.K529K; 7:74120602-74120602	skin	malignant_melanoma	Substitution - coding silent
c.1333G>A; p.A445T; 7:74111696-74111696	liver	carcinoma	Substitution - Missense
c.500C>T; p.S167F; 7:74099130-74099130	skin	malignant_melanoma	Substitution - Missense
c.1333G>A; p.A445T; 7:74111696-74111696	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.857G>T; p.S286I; 7:74106219-74106219	breast	carcinoma	Substitution - Missense
c.827C>A; p.P276Q; 7:74106189-74106189	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1724_1725insC; p.S578fs*67; 7:74120992-74120993	breast	carcinoma	Insertion - Frameshift
c.777C>T; p.H259H; 7:74106139-74106139	ovary	other; neoplasm	Substitution - coding silent
c.1612G>A; p.V538I; 7:74120627-74120627	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.436G>A; p.V146I; 7:74099066-74099066	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.777C>T; p.H259H; 7:74106139-74106139	ovary	other; neoplasm	Substitution - coding silent
c.827C>T; p.P276L; 7:74106189-74106189	liver	carcinoma	Substitution - Missense
c.827C>T; p.P276L; 7:74106189-74106189	liver	carcinoma	Substitution - Missense
c.313C>T; p.H105Y; 7:74097101-74097101	breast	carcinoma	Substitution - Missense
c.866G>A; p.R289Q; 7:74106228-74106228	liver	carcinoma	Substitution - Missense
c.866G>A; p.R289Q; 7:74106228-74106228	liver	carcinoma	Substitution - Missense
c.441C>T; p.I147I; 7:74099071-74099071	skin	malignant_melanoma	Substitution - coding silent
c.1494C>T; p.L498L; 7:74115885-74115885	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.179C>T; p.S60L; 7:74096648-74096648	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.865C>T; p.R289W; 7:74106227-74106227	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.487G>A; p.V163I; 7:74099117-74099117	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1785A>C; p.P595P; 7:74121142-74121142	thyroid	other; neoplasm	Substitution - coding silent
c.430A>G; p.T144A; 7:74099060-74099060	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.712G>T; p.E238*; 7:74105978-74105978	pituitary; craniopharyngeal_duct	craniopharyngioma; adamantinomatous	Substitution - Nonsense
c.1186G>A; p.V396M; 7:74108938-74108938	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1553C>T; p.P518L; 7:74115944-74115944	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.535T>C; p.S179P; 7:74099165-74099165	central_nervous_system; brain	glioma	Substitution - Missense
c.1119C>T; p.F373F; 7:74107924-74107924	skin	malignant_melanoma	Substitution - coding silent
c.1119C>T; p.F373F; 7:74107924-74107924	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1344+2T>G; p.?; 7:74111709-74111709	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.526C>T; p.R176C; 7:74099156-74099156	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.526C>T; p.R176C; 7:74099156-74099156	central_nervous_system; brain	atypical_teratoid-rhabdoid_tumour	Substitution - Missense
c.1858C>T; p.Q620*; 7:74121215-74121215	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1265G>A; p.R422Q; 7:74109017-74109017	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1002C>T; p.F334F; 7:74107130-74107130	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1388C>T; p.S463F; 7:74111976-74111976	skin	malignant_melanoma	Substitution - Missense
c.1209C>G; p.L403L; 7:74108961-74108961	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.455C>A; p.P152H; 7:74099085-74099085	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.455C>A; p.P152H; 7:74099085-74099085	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.598C>T; p.R200C; 7:74099228-74099228	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1750G>A; p.V584M; 7:74121018-74121018	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1275C>T; p.I425I; 7:74109027-74109027	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1376G>A; p.R459Q; 7:74111964-74111964	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; plasma_cell_myeloma	Substitution - Missense
c.1634G>A; p.R545Q; 7:74120902-74120902	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1789T>C; p.F597L; 7:74121146-74121146	thyroid	other; neoplasm	Substitution - Missense
c.520G>A; p.G174S; 7:74099150-74099150	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1405C>T; p.R469C; 7:74111993-74111993	skin	malignant_melanoma	Substitution - Missense
c.995G>A; p.R332H; 7:74107123-74107123	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.995G>A; p.R332H; 7:74107123-74107123	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.1664G>A; p.R555H; 7:74120932-74120932	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.412T>C; p.Y138H; 7:74099042-74099042	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1938C>T; p.P646P; 7:74121295-74121295	breast	carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation