lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3959
Symbol	LGALS3BP
Synonymous	90K\|BTBD17B\|CyCAP\|M2BP\|MAC-2-BP\|TANGO10B\|gp90
Full name	lectin, galactoside-binding, soluble, 3 binding protein
Gene description	L3 antigen\|MAC2BP\|Mac-2-binding protein\|basement membrane autoantigen p105\|galectin-3-binding protein\|lectin galactoside-binding soluble 3-binding protein\|mac-2 BP\|serum protein 90K\|transport and golgi organization 10 homolog B\|tumor-associated antigen 90
Cytoband	17q25
Gene type	protein-coding
Synonymous	MIM:600626; HGNC:HGNC:6564; Ensembl:ENSG00000108679; HPRD:02796; Vega:OTTHUMG00000177572

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1350C>T; p.P450P; 17:78971984-78971984	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.267T>C; p.D89D; 17:78974797-78974797	thyroid	other; neoplasm	Substitution - coding silent
c.338G>A; p.C113Y; 17:78974726-78974726	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.662T>C; p.L221P; 17:78972672-78972672	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1575C>A; p.L525L; 17:78971759-78971759	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.374A>G; p.N125S; 17:78974690-78974690	skin	malignant_melanoma	Substitution - Missense
c.975G>A; p.V325V; 17:78972359-78972359	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1370_1375delCCTACC; p.P457_Y458delPY; 17:78971959-78971964	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - In frame
c.429T>C; p.L143L; 17:78973170-78973170	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1194_1195CC>TT; p.L399F; 17:78972139-78972140	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.972C>A; p.A324A; 17:78972362-78972362	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1307G>A; p.R436Q; 17:78972027-78972027	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.194T>G; p.L65R; 17:78976015-78976015	skin	malignant_melanoma	Substitution - Missense
c.658A>G; p.T220A; 17:78972676-78972676	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; large_cell	Substitution - Missense
c.107G>A; p.R36H; 17:78976102-78976102	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; Burkitt_lymphoma	Substitution - Missense
c.1530C>T; p.G510G; 17:78971804-78971804	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1622A>G; p.K541R; 17:78971712-78971712	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1739A>G; p.N580S; 17:78971595-78971595	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.159G>T; p.W53C; 17:78976050-78976050	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.965T>A; p.L322Q; 17:78972369-78972369	liver	carcinoma	Substitution - Missense
c.772C>T; p.Q258*; 17:78972562-78972562	skin	malignant_melanoma	Substitution - Nonsense
c.965T>A; p.L322Q; 17:78972369-78972369	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1221G>A; p.R407R; 17:78972113-78972113	breast	carcinoma	Substitution - coding silent
c.1174G>A; p.A392T; 17:78972160-78972160	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1174G>A; p.A392T; 17:78972160-78972160	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1174G>A; p.A392T; 17:78972160-78972160	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.790T>G; p.Y264D; 17:78972544-78972544	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1658C>T; p.S553L; 17:78971676-78971676	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.440T>G; p.F147C; 17:78973159-78973159	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.1380C>T; p.S460S; 17:78971954-78971954	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.730G>A; p.A244T; 17:78972604-78972604	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1654A>T; p.S552C; 17:78971680-78971680	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1010A>C; p.E337A; 17:78972324-78972324	skin	malignant_melanoma	Substitution - Missense
c.589G>A; p.V197M; 17:78973010-78973010	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.489C>T; p.G163G; 17:78973110-78973110	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.187C>T; p.R63W; 17:78976022-78976022	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1348_1349CC>TT; p.P450>?; 17:78971985-78971986	NS	malignant_melanoma	Complex
c.856A>G; p.N286D; 17:78972478-78972478	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.756_757delCC; p.Q253fs*84; 17:78972577-78972578	pancreas	pancreatic_intraepithelial_neoplasia_(PanIN)	Deletion - Frameshift
c.785A>G; p.D262G; 17:78972549-78972549	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.785A>G; p.D262G; 17:78972549-78972549	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.47C>G; p.T16S; 17:78977145-78977145	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1630A>G; p.I544V; 17:78971704-78971704	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.204G>A; p.E68E; 17:78976005-78976005	skin	malignant_melanoma	Substitution - coding silent
c.169G>C; p.D57H; 17:78976040-78976040	pancreas	carcinoma	Substitution - Missense
c.169G>C; p.D57H; 17:78976040-78976040	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.929G>A; p.R310K; 17:78972405-78972405	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.546C>T; p.A182A; 17:78973053-78973053	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1563A>G; p.K521K; 17:78971771-78971771	skin	malignant_melanoma	Substitution - coding silent
c.1372T>C; p.Y458H; 17:78971962-78971962	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1374C>T; p.Y458Y; 17:78971960-78971960	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1151A>T; p.H384L; 17:78972183-78972183	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.164T>C; p.L55P; 17:78976045-78976045	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.12G>A; p.P4P; 17:78977180-78977180	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.554T>C; p.L185P; 17:78973045-78973045	liver	carcinoma	Substitution - Missense
c.1306C>A; p.R436R; 17:78972028-78972028	pancreas	carcinoma	Substitution - coding silent
c.784G>T; p.D262Y; 17:78972550-78972550	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1326T>C; p.Y442Y; 17:78972008-78972008	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1659G>A; p.S553S; 17:78971675-78971675	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1659G>A; p.S553S; 17:78971675-78971675	central_nervous_system; brain	glioma	Substitution - coding silent
c.1555G>A; p.E519K; 17:78971779-78971779	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.810_811AG>TT; p.G271W; 17:78972523-78972524	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.502G>C; p.G168R; 17:78973097-78973097	liver	carcinoma	Substitution - Missense
c.502G>C; p.G168R; 17:78973097-78973097	liver	carcinoma	Substitution - Missense
c.1350delC; p.S451fs*73; 17:78971984-78971984	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.861C>T; p.F287F; 17:78972473-78972473	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.165G>A; p.L55L; 17:78976044-78976044	pancreas	carcinoma	Substitution - coding silent
c.165G>A; p.L55L; 17:78976044-78976044	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.186C>T; p.C62C; 17:78976023-78976023	breast	carcinoma	Substitution - coding silent
c.1297C>G; p.Q433E; 17:78972037-78972037	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1736C>T; p.T579I; 17:78971598-78971598	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.972C>T; p.A324A; 17:78972362-78972362	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1659G>T; p.S553S; 17:78971675-78971675	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1564G>A; p.A522T; 17:78971770-78971770	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1008T>C; p.H336H; 17:78972326-78972326	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.269A>G; p.E90G; 17:78974795-78974795	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.942G>A; p.A314A; 17:78972392-78972392	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.244G>C; p.G82R; 17:78975965-78975965	breast	carcinoma	Substitution - Missense
c.1670C>T; p.S557F; 17:78971664-78971664	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1670C>T; p.S557F; 17:78971664-78971664	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1108G>A; p.E370K; 17:78972226-78972226	liver	carcinoma	Substitution - Missense
c.1108G>A; p.E370K; 17:78972226-78972226	liver	carcinoma	Substitution - Missense
c.1628C>T; p.A543V; 17:78971706-78971706	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.946C>T; p.P316S; 17:78972388-78972388	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.268G>A; p.E90K; 17:78974796-78974796	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1417G>A; p.D473N; 17:78971917-78971917	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1692_1693insC; p.H565fs*>22; 17:78971641-78971642	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Insertion - Frameshift
c.729C>T; p.C243C; 17:78972605-78972605	prostate	carcinoma	Substitution - coding silent
c.1510C>A; p.L504M; 17:78971824-78971824	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1510C>A; p.L504M; 17:78971824-78971824	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation