lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3939
Symbol	LDHA
Synonymous	GSD11\|HEL-S-133P\|LDH1\|LDHM\|PIG19
Full name	lactate dehydrogenase A
Gene description	L-lactate dehydrogenase A chain\|LDH muscle subunit\|LDH-A\|LDH-M\|cell proliferation-inducing gene 19 protein\|epididymis secretory sperm binding protein Li 133P\|lactate dehydrogenase M\|proliferation-inducing gene 19\|renal carcinoma antigen NY-REN-59
Cytoband	11p15.4
Gene type	protein-coding
Synonymous	MIM:150000; HGNC:HGNC:6535; Ensembl:ENSG00000134333; HPRD:01025; Vega:OTTHUMG00000167721

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.656G>A; p.G219E; 11:18403757-18403757	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.112A>G; p.S38G; 11:18396954-18396954	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.821C>T; p.S274F; 11:18405559-18405559	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.219A>G; p.R73R; 11:18399523-18399523	kidney	other; neoplasm	Substitution - coding silent
c.358A>C; p.I120L; 11:18400950-18400950	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.180A>G; p.G60G; 11:18399484-18399484	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.592+1G>A; p.?; 11:18403014-18403014	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.626T>C; p.V209A; 11:18403727-18403727	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.626T>C; p.V209A; 11:18403727-18403727	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.626T>C; p.V209A; 11:18403727-18403727	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.626T>C; p.V209A; 11:18403727-18403727	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.626T>C; p.V209A; 11:18403727-18403727	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.626T>C; p.V209A; 11:18403727-18403727	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.107C>T; p.A36V; 11:18396949-18396949	ovary	other; neoplasm	Substitution - Missense
c.559G>A; p.G187R; 11:18402980-18402980	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.107C>T; p.A36V; 11:18396949-18396949	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.410C>G; p.S137*; 11:18401002-18401002	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.623G>C; p.G208A; 11:18403724-18403724	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.522delG; p.E176fs*8; 11:18402943-18402943	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.762C>G; p.L254L; 11:18405500-18405500	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.918G>T; p.V306V; 11:18407200-18407200	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.239G>T; p.G80V; 11:18399543-18399543	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.163G>A; p.E55K; 11:18399467-18399467	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.163G>A; p.E55K; 11:18399467-18399467	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.163G>A; p.E55K; 11:18399467-18399467	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.163G>A; p.E55K; 11:18399467-18399467	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.163G>A; p.E55K; 11:18399467-18399467	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.163G>A; p.E55K; 11:18399467-18399467	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.842A>G; p.Y281C; 11:18407124-18407124	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.304G>C; p.E102Q; 11:18400896-18400896	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.348C>A; p.I116I; 11:18400940-18400940	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.931G>A; p.E311K; 11:18407213-18407213	breast	carcinoma	Substitution - Missense
c.199C>G; p.H67D; 11:18399503-18399503	skin	malignant_melanoma	Substitution - Missense
c.114T>C; p.S38S; 11:18396956-18396956	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.889C>T; p.Q297*; 11:18407171-18407171	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.162C>T; p.I54I; 11:18399466-18399466	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.465A>C; p.K155N; 11:18402886-18402886	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.385C>T; p.P129S; 11:18400977-18400977	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.810G>A; p.V270V; 11:18405548-18405548	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.706G>C; p.E236Q; 11:18403807-18403807	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.208C>G; p.L70V; 11:18399512-18399512	thyroid	carcinoma	Substitution - Missense
c.511C>T; p.R171C; 11:18402932-18402932	skin	malignant_melanoma	Substitution - Missense
c.430A>G; p.T144A; 11:18402851-18402851	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.430A>G; p.T144A; 11:18402851-18402851	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.430A>G; p.T144A; 11:18402851-18402851	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.834G>T; p.K278N; 11:18405572-18405572	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.755T>C; p.I252T; 11:18405493-18405493	thyroid	carcinoma	Substitution - Missense
c.533delT; p.L178fs*6; 11:18402954-18402954	soft_tissue; blood_vessel	angiosarcoma	Deletion - Frameshift
c.178G>T; p.G60*; 11:18399482-18399482	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.54C>A; p.T18T; 11:18396896-18396896	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.76G>C; p.V26L; 11:18396918-18396918	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.220A>T; p.T74S; 11:18399524-18399524	kidney	other; neoplasm	Substitution - Missense
c.387G>A; p.P129P; 11:18400979-18400979	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.689T>C; p.V230A; 11:18403790-18403790	skin	malignant_melanoma	Substitution - Missense
c.152T>G; p.V51G; 11:18399456-18399456	lung	carcinoma; large_cell_carcinoma	Substitution - Missense
c.152T>G; p.V51G; 11:18399456-18399456	lung	carcinoma; large_cell_carcinoma	Substitution - Missense
c.113G>C; p.S38T; 11:18396955-18396955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.483C>T; p.S161S; 11:18402904-18402904	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.642G>A; p.L214L; 11:18403743-18403743	breast	carcinoma	Substitution - coding silent
c.66G>T; p.K22N; 11:18396908-18396908	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.21G>A; p.Q7Q; 11:18396863-18396863	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.646C>T; p.P216S; 11:18403747-18403747	skin	malignant_melanoma	Substitution - Missense
c.544C>T; p.P182S; 11:18402965-18402965	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.559G>T; p.G187W; 11:18402980-18402980	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.944G>A; p.R315H; 11:18407226-18407226	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.769G>A; p.A257T; 11:18405507-18405507	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.769G>A; p.A257T; 11:18405507-18405507	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.317G>A; p.R106H; 11:18400909-18400909	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.179G>A; p.G60E; 11:18399483-18399483	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.214C>T; p.L72F; 11:18399518-18399518	skin	malignant_melanoma	Substitution - Missense
c.53delC; p.Q20fs*21; 11:18396895-18396895	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.436G>T; p.V146L; 11:18402857-18402857	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.82G>A; p.V28I; 11:18396924-18396924	breast	carcinoma	Substitution - Missense
c.8C>T; p.T3I; 11:18396850-18396850	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation