lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3833
Symbol	KIFC1
Synonymous	HSET\|KNSL2
Full name	kinesin family member C1
Gene description	kinesin-like 2\|kinesin-like protein 2\|kinesin-like protein KIFC1\|kinesin-related protein HSET
Cytoband	6p21.3
Gene type	protein-coding
Synonymous	MIM:603763; HGNC:HGNC:6389; Ensembl:ENSG00000237649; Vega:OTTHUMG00000031209

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.415T>C; p.L139L; 6:33403788-33403788	breast	carcinoma	Substitution - coding silent
c.1846C>T; p.R616W; 6:33406610-33406610	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.338C>A; p.P113H; 6:33403518-33403518	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1667A>T; p.Q556L; 6:33406326-33406326	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1485G>T; p.E495D; 6:33405580-33405580	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.262T>A; p.S88T; 6:33403325-33403325	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1408C>T; p.R470W; 6:33405503-33405503	skin	malignant_melanoma	Substitution - Missense
c.1408C>T; p.R470W; 6:33405503-33405503	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.629G>A; p.R210H; 6:33404002-33404002	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1973C>T; p.S658F; 6:33406871-33406871	breast	carcinoma	Substitution - Missense
c.2021G>T; p.*674L; 6:33409689-33409689	breast	carcinoma	Nonstop extension
c.842C>T; p.A281V; 6:33404937-33404937	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.194C>T; p.S65F; 6:33398331-33398331	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.1781G>A; p.S594N; 6:33406440-33406440	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.509A>G; p.Q170R; 6:33403882-33403882	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1678C>T; p.P560S; 6:33406337-33406337	skin	malignant_melanoma	Substitution - Missense
c.1678C>T; p.P560S; 6:33406337-33406337	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1964G>T; p.R655L; 6:33406862-33406862	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.959T>C; p.V320A; 6:33405054-33405054	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.458G>T; p.C153F; 6:33403831-33403831	breast	carcinoma	Substitution - Missense
c.154C>T; p.R52W; 6:33398291-33398291	prostate	carcinoma	Substitution - Missense
c.955C>T; p.P319S; 6:33405050-33405050	breast	carcinoma	Substitution - Missense
c.1523C>T; p.S508F; 6:33405618-33405618	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.253C>G; p.Q85E; 6:33403316-33403316	breast	carcinoma	Substitution - Missense
c.1039C>T; p.R347C; 6:33405134-33405134	liver	carcinoma	Substitution - Missense
c.1039C>T; p.R347C; 6:33405134-33405134	liver	carcinoma	Substitution - Missense
c.1359G>C; p.W453C; 6:33405454-33405454	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1280A>C; p.D427A; 6:33405375-33405375	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.499C>A; p.L167I; 6:33403872-33403872	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1172T>C; p.I391T; 6:33405267-33405267	skin	malignant_melanoma	Substitution - Missense
c.621G>T; p.K207N; 6:33403994-33403994	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1969G>A; p.A657T; 6:33406867-33406867	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1106G>T; p.R369L; 6:33405201-33405201	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.666G>A; p.T222T; 6:33404039-33404039	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelofibrosis	Substitution - coding silent
c.1933G>A; p.E645K; 6:33406831-33406831	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1508G>A; p.R503Q; 6:33405603-33405603	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1931A>G; p.E644G; 6:33406829-33406829	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.865C>T; p.R289C; 6:33404960-33404960	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1562G>T; p.R521L; 6:33406221-33406221	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.997C>T; p.L333L; 6:33405092-33405092	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1840C>T; p.P614S; 6:33406604-33406604	skin	malignant_melanoma	Substitution - Missense
c.17C>T; p.S6F; 6:33398033-33398033	skin	malignant_melanoma	Substitution - Missense
c.272C>T; p.T91I; 6:33403335-33403335	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1881T>C; p.S627S; 6:33406645-33406645	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1419G>T; p.L473L; 6:33405514-33405514	thyroid	other; neoplasm	Substitution - coding silent
c.426G>T; p.Q142H; 6:33403799-33403799	prostate	carcinoma	Substitution - Missense
c.212C>T; p.S71F; 6:33398349-33398349	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.780A>G; p.A260A; 6:33404875-33404875	breast	carcinoma	Substitution - coding silent
c.1677C>T; p.A559A; 6:33406336-33406336	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1066C>T; p.R356W; 6:33405161-33405161	breast	carcinoma	Substitution - Missense
c.1255A>G; p.T419A; 6:33405350-33405350	liver	carcinoma	Substitution - Missense
c.1255A>G; p.T419A; 6:33405350-33405350	liver	carcinoma	Substitution - Missense
c.1312C>T; p.L438L; 6:33405407-33405407	pancreas	carcinoma	Substitution - coding silent
c.988G>C; p.G330R; 6:33405083-33405083	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.219T>C; p.T73T; 6:33398356-33398356	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.219T>C; p.T73T; 6:33398356-33398356	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.655C>T; p.R219W; 6:33404028-33404028	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1609C>T; p.R537C; 6:33406268-33406268	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1542C>T; p.D514D; 6:33406201-33406201	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1827+2T>G; p.?; 6:33406488-33406488	breast	carcinoma	Unknown
c.1126C>T; p.R376W; 6:33405221-33405221	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.150G>T; p.K50N; 6:33398166-33398166	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.370C>A; p.P124T; 6:33403743-33403743	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.596C>T; p.A199V; 6:33403969-33403969	skin; trunk	malignant_melanoma	Substitution - Missense
c.1237G>A; p.G413S; 6:33405332-33405332	liver	carcinoma	Substitution - Missense
c.1003C>T; p.P335S; 6:33405098-33405098	skin	malignant_melanoma	Substitution - Missense
c.899T>G; p.L300R; 6:33404994-33404994	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1722C>T; p.P574P; 6:33406381-33406381	skin	malignant_melanoma	Substitution - coding silent
c.945C>T; p.C315C; 6:33405040-33405040	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.95G>T; p.G32V; 6:33398111-33398111	breast	carcinoma	Substitution - Missense
c.1271C>T; p.P424L; 6:33405366-33405366	skin	malignant_melanoma	Substitution - Missense
c.2005C>T; p.Q669*; 6:33409673-33409673	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2005C>T; p.Q669*; 6:33409673-33409673	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.880G>C; p.E294Q; 6:33404975-33404975	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.693_694insA; p.Q234fs*52; 6:33404066-33404067	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1063G>A; p.E355K; 6:33405158-33405158	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.135C>T; p.G45G; 6:33398151-33398151	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.261T>C; p.V87V; 6:33403324-33403324	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.670G>C; p.E224Q; 6:33404043-33404043	breast	carcinoma	Substitution - Missense
c.1118C>T; p.S373F; 6:33405213-33405213	skin	malignant_melanoma	Substitution - Missense
c.1600C>T; p.R534W; 6:33406259-33406259	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1488G>A; p.E496E; 6:33405583-33405583	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1583G>A; p.R528H; 6:33406242-33406242	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2000C>T; p.T667I; 6:33409668-33409668	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1974C>T; p.S658S; 6:33406872-33406872	skin	malignant_melanoma	Substitution - coding silent
c.1734C>T; p.L578L; 6:33406393-33406393	breast	carcinoma	Substitution - coding silent
c.727G>A; p.G243R; 6:33404100-33404100	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.539C>A; p.A180D; 6:33403912-33403912	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1964G>A; p.R655H; 6:33406862-33406862	breast	carcinoma	Substitution - Missense
c.208C>G; p.P70A; 6:33398345-33398345	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1379G>T; p.S460I; 6:33405474-33405474	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1339G>C; p.E447Q; 6:33405434-33405434	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.337C>A; p.P113T; 6:33403517-33403517	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.748G>A; p.E250K; 6:33404121-33404121	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1194C>T; p.A398A; 6:33405289-33405289	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.722G>A; p.R241Q; 6:33404095-33404095	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.553C>T; p.R185C; 6:33403926-33403926	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.263C>T; p.S88F; 6:33403326-33403326	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.367C>T; p.P123S; 6:33403740-33403740	skin	malignant_melanoma	Substitution - Missense
c.1286A>G; p.Q429R; 6:33405381-33405381	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.895C>T; p.R299*; 6:33404990-33404990	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.882A>C; p.E294D; 6:33404977-33404977	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1597G>A; p.E533K; 6:33406256-33406256	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation