lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3832
Symbol	KIF11
Synonymous	EG5\|HKSP\|KNSL1\|MCLMR\|TRIP5
Full name	kinesin family member 11
Gene description	TR-interacting protein 5\|TRIP-5\|kinesin-like protein 1\|kinesin-like protein KIF11\|kinesin-like spindle protein HKSP\|kinesin-related motor protein Eg5\|thyroid receptor-interacting protein 5
Cytoband	10q24.1
Gene type	protein-coding
Synonymous	MIM:148760; HGNC:HGNC:6388; Ensembl:ENSG00000138160; HPRD:01023; Vega:OTTHUMG00000018761

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1278T>G; p.I426M; 10:92628868-92628868	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.892G>A; p.V298I; 10:92613479-92613479	pancreas	carcinoma	Substitution - Missense
c.892G>A; p.V298I; 10:92613479-92613479	pancreas	carcinoma	Substitution - Missense
c.3152G>A; p.R1051Q; 10:92653777-92653777	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3154G>C; p.A1052P; 10:92653779-92653779	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2577T>C; p.S859S; 10:92648241-92648241	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2577T>C; p.S859S; 10:92648241-92648241	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2577T>C; p.S859S; 10:92648241-92648241	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1174G>A; p.A392T; 10:92621430-92621430	kidney	other; neoplasm	Substitution - Missense
c.1196A>G; p.Y399C; 10:92621452-92621452	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1196A>G; p.Y399C; 10:92621452-92621452	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1196A>G; p.Y399C; 10:92621452-92621452	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1196A>G; p.Y399C; 10:92621452-92621452	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2922+2T>C; p.?; 10:92649988-92649988	stomach	carcinoma; adenocarcinoma	Unknown
c.812A>G; p.N271S; 10:92613399-92613399	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.543A>G; p.R181R; 10:92609175-92609175	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2958T>A; p.Y986*; 10:92650436-92650436	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Nonsense
c.1120C>T; p.L374F; 10:92616824-92616824	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2404G>A; p.D802N; 10:92645499-92645499	urinary_tract; bladder	carcinoma	Substitution - Missense
c.430T>A; p.F144I; 10:92609062-92609062	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1904C>T; p.S635L; 10:92637212-92637212	skin	malignant_melanoma	Substitution - Missense
c.27G>T; p.A9A; 10:92593402-92593402	endometrium	carcinoma; serous_carcinoma	Substitution - coding silent
c.2459A>C; p.E820A; 10:92645554-92645554	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2386G>T; p.E796*; 10:92645481-92645481	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2547+1G>A; p.?; 10:92645643-92645643	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1433A>G; p.E478G; 10:92630303-92630303	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1378G>T; p.E460*; 10:92630248-92630248	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2296A>C; p.T766P; 10:92645391-92645391	liver	carcinoma	Substitution - Missense
c.1378G>T; p.E460*; 10:92630248-92630248	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1150C>T; p.R384C; 10:92621406-92621406	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.398C>T; p.A133V; 10:92609030-92609030	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1617T>C; p.N539N; 10:92632608-92632608	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1748C>T; p.T583I; 10:92633668-92633668	liver	carcinoma	Substitution - Missense
c.617A>G; p.N206S; 10:92609428-92609428	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2878A>C; p.M960L; 10:92649942-92649942	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1912A>T; p.M638L; 10:92637220-92637220	skin; upper_arm	malignant_melanoma	Substitution - Missense
c.2012delA; p.K673fs*3; 10:92637397-92637397	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2841C>G; p.L947L; 10:92649905-92649905	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1817T>C; p.M606T; 10:92633737-92633737	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2197T>G; p.F733V; 10:92639830-92639830	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.636A>T; p.Q212H; 10:92609447-92609447	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2635_2636insT; p.L881fs*2; 10:92648299-92648300	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.5C>T; p.A2V; 10:92593380-92593380	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2253G>A; p.Q751Q; 10:92639886-92639886	liver	carcinoma	Substitution - coding silent
c.1178G>A; p.R393H; 10:92621434-92621434	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.868C>T; p.Q290*; 10:92613455-92613455	skin	malignant_melanoma	Substitution - Nonsense
c.1798G>T; p.V600F; 10:92633718-92633718	breast	carcinoma	Substitution - Missense
c.1598delT; p.F534fs*5; 10:92632589-92632589	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.3022G>A; p.G1008R; 10:92650500-92650500	prostate	adenoma	Substitution - Missense
c.2114G>A; p.G705E; 10:92637499-92637499	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1259T>A; p.V420E; 10:92628849-92628849	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1703+8A>T; p.?; 10:92632702-92632702	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1006A>G; p.I336V; 10:92613593-92613593	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1470G>T; p.E490D; 10:92630340-92630340	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1498C>T; p.L500F; 10:92632489-92632489	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.766G>A; p.V256I; 10:92613107-92613107	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2262A>G; p.I754M; 10:92639895-92639895	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2638T>G; p.F880V; 10:92648302-92648302	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.573+4A>C; p.?; 10:92609209-92609209	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Unknown
c.2980G>A; p.E994K; 10:92650458-92650458	skin	malignant_melanoma	Substitution - Missense
c.2156_2157CC>TT; p.S719F; 10:92637541-92637542	skin	malignant_melanoma	Substitution - Missense
c.1583C>A; p.A528E; 10:92632574-92632574	parathyroid	adenoma	Substitution - Missense
c.2398C>T; p.H800Y; 10:92645493-92645493	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1137G>T; p.T379T; 10:92621393-92621393	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.2252A>G; p.Q751R; 10:92639885-92639885	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.42G>A; p.E14E; 10:92593417-92593417	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.238G>T; p.D80Y; 10:92606646-92606646	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.248G>A; p.R83Q; 10:92606656-92606656	breast	carcinoma	Substitution - Missense
c.464C>T; p.S155L; 10:92609096-92609096	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.175G>A; p.D59N; 10:92606362-92606362	breast	carcinoma	Substitution - Missense
c.514C>G; p.L172V; 10:92609146-92609146	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2847T>A; p.D949E; 10:92649911-92649911	skin	malignant_melanoma	Substitution - Missense
c.2526G>T; p.Q842H; 10:92645621-92645621	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.113A>T; p.H38L; 10:92606300-92606300	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1288G>C; p.E430Q; 10:92628878-92628878	breast	carcinoma	Substitution - Missense
c.574-6G>T; p.?; 10:92609379-92609379	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.2971C>G; p.L991V; 10:92650449-92650449	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1159C>T; p.R387*; 10:92621415-92621415	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1159C>T; p.R387*; 10:92621415-92621415	pancreas	carcinoma	Substitution - Nonsense
c.109G>A; p.A37T; 10:92606296-92606296	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.109G>A; p.A37T; 10:92606296-92606296	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.652G>A; p.A218T; 10:92609463-92609463	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1808T>G; p.I603S; 10:92633728-92633728	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.392C>T; p.P131L; 10:92609024-92609024	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1891G>A; p.D631N; 10:92637199-92637199	breast	carcinoma	Substitution - Missense
c.1614G>A; p.L538L; 10:92632605-92632605	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2709A>C; p.K903N; 10:92648373-92648373	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2709A>C; p.K903N; 10:92648373-92648373	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1860A>G; p.V620V; 10:92633780-92633780	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2390C>T; p.S797F; 10:92645485-92645485	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1860A>G; p.V620V; 10:92633780-92633780	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1542T>C; p.H514H; 10:92632533-92632533	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2583C>A; p.D861E; 10:92648247-92648247	ovary	other; neoplasm	Substitution - Missense
c.2504C>G; p.S835C; 10:92645599-92645599	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1554T>G; p.D518E; 10:92632545-92632545	ovary	other; neoplasm	Substitution - Missense
c.402T>G; p.G134G; 10:92609034-92609034	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2442G>C; p.E814D; 10:92645537-92645537	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.433G>T; p.E145*; 10:92609065-92609065	skin	malignant_melanoma	Substitution - Nonsense
c.402T>C; p.G134G; 10:92609034-92609034	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.402T>C; p.G134G; 10:92609034-92609034	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.980G>A; p.R327H; 10:92613567-92613567	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1129G>C; p.E377Q; 10:92621385-92621385	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2575A>C; p.S859R; 10:92648239-92648239	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1198A>G; p.I400V; 10:92621454-92621454	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.935G>A; p.R312Q; 10:92613522-92613522	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1986G>C; p.L662F; 10:92637294-92637294	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1139A>T; p.E380V; 10:92621395-92621395	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1171G>A; p.A391T; 10:92621427-92621427	liver	carcinoma	Substitution - Missense
c.3111A>T; p.E1037D; 10:92653736-92653736	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3111A>T; p.E1037D; 10:92653736-92653736	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1551G>A; p.L517L; 10:92632542-92632542	pancreas	carcinoma	Substitution - coding silent
c.380G>A; p.W127*; 10:92607230-92607230	pancreas	carcinoma	Substitution - Nonsense
c.311A>G; p.Y104C; 10:92607161-92607161	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1384G>A; p.E462K; 10:92630254-92630254	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1012C>T; p.P338S; 10:92613599-92613599	skin	malignant_melanoma	Substitution - Missense
c.689C>T; p.A230V; 10:92609500-92609500	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.586A>C; p.I196L; 10:92609397-92609397	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1342G>A; p.D448N; 10:92630212-92630212	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2817A>G; p.V939V; 10:92649881-92649881	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1804C>G; p.Q602E; 10:92633724-92633724	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation