Cancer metastasis database

Annotation category 5

Gene information

Gene ID 3816
Symbol

KLK1

Synonymous

KLKR|Klk6|hK1

Full name

kallikrein 1

Gene description

glandular kallikrein 1|kallikrein 1, renal/pancreas/salivary|kallikrein serine protease 1|kallikrein-1|kidney/pancreas/salivary gland kallikrein|tissue kallikrein

Cytoband

19q13.3

Gene type

protein-coding

Synonymous

MIM:147910; HGNC:HGNC:6357; Ensembl:ENSG00000167748; HPRD:01003; Vega:OTTHUMG00000182876

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.53C>T; p.A18V; 19:50821865-50821865

 livercarcinomaSubstitution - Missense

c.53C>T; p.A18V; 19:50821865-50821865

 livercarcinomaSubstitution - Missense

c.329C>T; p.T110I; 19:50820321-50820321

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.442G>A; p.E148K; 19:50820208-50820208

 skinmalignant_melanomaSubstitution - Missense

c.292C>T; p.H98Y; 19:50820358-50820358

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.784T>A; p.S262T; 19:50819199-50819199

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.13G>T; p.V5F; 19:50823736-50823736

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.561_562insA; p.A188fs*26; 19:50819970-50819971

 breastcarcinomaInsertion - Frameshift

c.548A>C; p.D183A; 19:50819984-50819984

 central_nervous_system; braingliomaSubstitution - Missense

c.405T>C; p.D135D; 19:50820245-50820245

 thyroidother; neoplasmSubstitution - coding silent

c.583G>C; p.D195H; 19:50819949-50819949

 breastcarcinomaSubstitution - Missense

c.763G>A; p.E255K; 19:50819220-50819220

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.763G>A; p.E255K; 19:50819220-50819220

 skinmalignant_melanomaSubstitution - Missense

c.170G>A; p.R57H; 19:50821748-50821748

 meningesmeningioma; haemangiopericyticSubstitution - Missense

c.170G>A; p.R57H; 19:50821748-50821748

 oesophaguscarcinomaSubstitution - Missense

c.42_43insG; p.T15fs*18; 19:50823706-50823707

 large_intestinecarcinoma; adenocarcinomaInsertion - Frameshift

c.492G>T; p.E164D; 19:50820158-50820158

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.698T>A; p.V233D; 19:50819285-50819285

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.559A>C; p.K187Q; 19:50819973-50819973

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.780G>T; p.E260D; 19:50819203-50819203

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.673C>T; p.Q225*; 19:50819310-50819310

 stomachcarcinoma; adenocarcinomaSubstitution - Nonsense

c.556A>G; p.K186E; 19:50819976-50819976

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.780G>T; p.E260D; 19:50819203-50819203

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.556A>G; p.K186E; 19:50819976-50819976

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.174G>A; p.Q58Q; 19:50821744-50821744

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.516C>T; p.L172L; 19:50820016-50820016

 breastcarcinomaSubstitution - coding silent

c.576G>A; p.K192K; 19:50819956-50819956

 breastcarcinomaSubstitution - coding silent

c.741G>A; p.V247V; 19:50819242-50819242

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.776C>T; p.A259V; 19:50819207-50819207

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.776C>T; p.A259V; 19:50819207-50819207

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.149G>T; p.C50F; 19:50821769-50821769

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.780G>C; p.E260D; 19:50819203-50819203

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.429C>A; p.P143P; 19:50820221-50820221

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.433G>C; p.E145Q; 19:50820217-50820217

 thyroidother; neoplasmSubstitution - Missense

c.603A>C; p.G201G; 19:50819929-50819929

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.701C>T; p.P234L; 19:50819282-50819282

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.547G>A; p.D183N; 19:50819985-50819985

 skinmalignant_melanomaSubstitution - Missense

c.291A>G; p.P97P; 19:50820359-50820359

 skinmalignant_melanomaSubstitution - coding silent

c.39_40GG>AA; p.G14R; 19:50823709-50823710

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.442G>C; p.E148Q; 19:50820208-50820208

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.46G>A; p.G16S; 19:50823703-50823703

 skinmalignant_melanomaSubstitution - Missense

c.626C>G; p.T209S; 19:50819906-50819906

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.42delG; p.T15fs*89; 19:50823707-50823707

 large_intestine; caecumcarcinoma; adenocarcinomaDeletion - Frameshift

c.42delG; p.T15fs*89; 19:50823707-50823707

 large_intestine; coloncarcinoma; adenocarcinomaDeletion - Frameshift

c.386C>G; p.P129R; 19:50820264-50820264

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.340G>A; p.D114N; 19:50820310-50820310

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.326A>C; p.H109P; 19:50820324-50820324

 skinmalignant_melanomaSubstitution - Missense

c.355C>A; p.H119N; 19:50820295-50820295

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.10C>T; p.L4L; 19:50823739-50823739

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.169C>A; p.R57S; 19:50821749-50821749

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.531C>T; p.L177L; 19:50820001-50820001

 skinmalignant_melanomaSubstitution - coding silent

c.648C>G; p.G216G; 19:50819335-50819335

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.753G>T; p.V251V; 19:50819230-50819230

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.772A>G; p.I258V; 19:50819211-50819211

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.60G>A; p.P20P; 19:50821858-50821858

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.762C>T; p.I254I; 19:50819221-50819221

 skinmalignant_melanomaSubstitution - coding silent