Cancer metastasis database

Annotation category 5

Gene information

Gene ID 3706
Symbol

ITPKA

Synonymous

IP3-3KA|IP3KA

Full name

inositol-trisphosphate 3-kinase A

Gene description

IP3 3-kinase A|IP3K A|inositol 1,4,5-trisphosphate 3-kinase A|insP 3-kinase A

Cytoband

15q15.1

Gene type

protein-coding

Synonymous

MIM:147521; HGNC:HGNC:6178; Ensembl:ENSG00000137825; HPRD:00941; Vega:OTTHUMG00000130343

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1110+8C>T; p.?; 15:41502511-41502511

 oesophagus; lower_thirdcarcinoma; adenocarcinomaUnknown

c.1386A>G; p.*462W; 15:41503166-41503166

 large_intestinecarcinoma; adenocarcinomaNonstop extension

c.665T>G; p.L222R; 15:41501713-41501713

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.706G>A; p.G236S; 15:41501754-41501754

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.341T>C; p.L114P; 15:41494268-41494268

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.646C>T; p.R216C; 15:41501694-41501694

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.709G>A; p.V237M; 15:41501757-41501757

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.785A>G; p.D262G; 15:41501833-41501833

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.678G>A; p.A226A; 15:41501726-41501726

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - coding silent

c.557A>T; p.Y186F; 15:41501530-41501530

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.678G>A; p.A226A; 15:41501726-41501726

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.834C>A; p.A278A; 15:41502027-41502027

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.861_862insATGT; p.K290fs*10; 15:41502054-41502055

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.841C>T; p.R281W; 15:41502034-41502034

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1112G>C; p.R371T; 15:41502789-41502789

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.187G>A; p.G63R; 15:41494114-41494114

 skin; trunkmalignant_melanomaSubstitution - Missense

c.1321G>A; p.E441K; 15:41503101-41503101

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1069C>T; p.R357C; 15:41502462-41502462

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.858G>T; p.K286N; 15:41502051-41502051

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1048C>T; p.R350*; 15:41502441-41502441

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.643G>A; p.E215K; 15:41501691-41501691

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.1023C>T; p.S341S; 15:41502416-41502416

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.566T>C; p.V189A; 15:41501539-41501539

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.566T>C; p.V189A; 15:41501539-41501539

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1362C>T; p.I454I; 15:41503142-41503142

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.635C>G; p.S212W; 15:41501683-41501683

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.493A>C; p.N165H; 15:41501466-41501466

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1319G>A; p.R440H; 15:41503099-41503099

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.682C>T; p.R228C; 15:41501730-41501730

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.682C>T; p.R228C; 15:41501730-41501730

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.928G>A; p.V310I; 15:41502121-41502121

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.259G>T; p.E87*; 15:41494186-41494186

 pancreascarcinomaSubstitution - Nonsense

c.529C>T; p.P177S; 15:41501502-41501502

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.881C>T; p.A294V; 15:41502074-41502074

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

c.388delT; p.S130fs*13; 15:41494315-41494315

 oesophagus; lower_thirdcarcinoma; adenocarcinomaDeletion - Frameshift

c.1054C>T; p.R352*; 15:41502447-41502447

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.1106T>C; p.V369A; 15:41502499-41502499

 breastcarcinomaSubstitution - Missense

c.903G>A; p.T301T; 15:41502096-41502096

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.903G>A; p.T301T; 15:41502096-41502096

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1046C>T; p.T349M; 15:41502439-41502439

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1046C>T; p.T349M; 15:41502439-41502439

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.739C>A; p.Q247K; 15:41501787-41501787

 pancreascarcinomaSubstitution - Missense

c.769G>C; p.G257R; 15:41501817-41501817

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1259C>T; p.T420I; 15:41503039-41503039

 skinmalignant_melanomaSubstitution - Missense

c.1179C>T; p.H393H; 15:41502856-41502856

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.865T>C; p.Y289H; 15:41502058-41502058

 stomachadenocarcinomaSubstitution - Missense

c.1318C>T; p.R440C; 15:41503098-41503098

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense