lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3694
Symbol	ITGB6
Synonymous	AI1H
Full name	integrin, beta 6
Gene description	integrin beta-6
Cytoband	2q24.2
Gene type	protein-coding
Synonymous	MIM:147558; HGNC:HGNC:6161; Ensembl:ENSG00000115221; HPRD:00947; Vega:OTTHUMG00000132026

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.970G>A; p.V324M; 2:160169259-160169259	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.970G>A; p.V324M; 2:160169259-160169259	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.958G>T; p.V320L; 2:160169271-160169271	liver	carcinoma	Substitution - Missense
c.1320_1321insT; p.G441fs*51; 2:160137773-160137774	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.921G>C; p.L307F; 2:160172569-160172569	ovary	other; neoplasm	Substitution - Missense
c.2064T>C; p.N688N; 2:160112117-160112117	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2267C>T; p.T756M; 2:160107680-160107680	pancreas	carcinoma	Substitution - Missense
c.93T>C; p.C31C; 2:160199227-160199227	breast	carcinoma	Substitution - coding silent
c.2246G>A; p.R749Q; 2:160107701-160107701	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1927G>A; p.E643K; 2:160123845-160123845	liver	carcinoma	Substitution - Missense
c.1927G>A; p.E643K; 2:160123845-160123845	liver	carcinoma	Substitution - Missense
c.898G>A; p.E300K; 2:160172592-160172592	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.142-9C>A; p.?; 2:160196429-160196429	pancreas	carcinoma	Unknown
c.441C>T; p.D147D; 2:160195521-160195521	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2029G>T; p.E677*; 2:160112152-160112152	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.783C>T; p.D261D; 2:160172707-160172707	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.783C>T; p.D261D; 2:160172707-160172707	thyroid	other; neoplasm	Substitution - coding silent
c.825T>C; p.H275H; 2:160172665-160172665	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1522C>T; p.H508Y; 2:160137572-160137572	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1813A>C; p.T605P; 2:160126449-160126449	skin	malignant_melanoma	Substitution - Missense
c.1522C>T; p.H508Y; 2:160137572-160137572	urinary_tract; bladder	carcinoma	Substitution - Missense
c.801C>T; p.V267V; 2:160172689-160172689	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1930G>T; p.E644*; 2:160123842-160123842	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1930G>T; p.E644*; 2:160123842-160123842	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.922G>A; p.E308K; 2:160169307-160169307	skin	malignant_melanoma	Substitution - Missense
c.1740G>A; p.T580T; 2:160126522-160126522	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1460G>A; p.G487E; 2:160137634-160137634	prostate	adenoma	Substitution - Missense
c.1727G>T; p.C576F; 2:160126535-160126535	breast	carcinoma	Substitution - Missense
c.1479C>T; p.G493G; 2:160137615-160137615	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.225C>T; p.I75I; 2:160196337-160196337	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1206C>G; p.H402Q; 2:160138101-160138101	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.151C>T; p.H51Y; 2:160196411-160196411	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1694G>A; p.C565Y; 2:160126568-160126568	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.821C>G; p.S274C; 2:160172669-160172669	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1717T>G; p.Y573D; 2:160126545-160126545	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1126G>C; p.E376Q; 2:160138181-160138181	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.716C>A; p.P239H; 2:160174017-160174017	breast	carcinoma	Substitution - Missense
c.2215C>A; p.R739S; 2:160107732-160107732	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelofibrosis	Substitution - Missense
c.1394C>T; p.S465F; 2:160137700-160137700	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1429G>T; p.G477W; 2:160137665-160137665	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1375G>T; p.E459*; 2:160137719-160137719	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.361C>T; p.L121L; 2:160195601-160195601	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.346G>T; p.G116C; 2:160196216-160196216	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2167G>A; p.G723R; 2:160107780-160107780	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.550C>T; p.P184S; 2:160195412-160195412	skin	malignant_melanoma	Substitution - Missense
c.776G>A; p.R259Q; 2:160172714-160172714	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.776G>A; p.R259Q; 2:160172714-160172714	kidney	carcinoma; renal_cell_carcinoma	Substitution - Missense
c.2285A>G; p.Y762C; 2:160101818-160101818	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.426C>T; p.S142S; 2:160195536-160195536	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1718A>G; p.Y573C; 2:160126544-160126544	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1633G>A; p.V545M; 2:160137461-160137461	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.503G>A; p.S168N; 2:160195459-160195459	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1115G>A; p.R372Q; 2:160138192-160138192	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.398T>C; p.V133A; 2:160195564-160195564	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.665G>T; p.R222I; 2:160174068-160174068	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.665G>T; p.R222I; 2:160174068-160174068	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1567A>G; p.I523V; 2:160137527-160137527	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.414C>G; p.L138L; 2:160195548-160195548	breast	carcinoma	Substitution - coding silent
c.1023C>T; p.Y341Y; 2:160142066-160142066	pancreas	carcinoma	Substitution - coding silent
c.2330G>A; p.R777K; 2:160101773-160101773	skin	malignant_melanoma	Substitution - Missense
c.1006C>T; p.H336Y; 2:160169223-160169223	skin	malignant_melanoma	Substitution - Missense
c.1782C>T; p.R594R; 2:160126480-160126480	central_nervous_system; brain	glioma	Substitution - coding silent
c.1782C>T; p.R594R; 2:160126480-160126480	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2186T>G; p.I729S; 2:160107761-160107761	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.550C>A; p.P184T; 2:160195412-160195412	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1255G>A; p.V419M; 2:160137839-160137839	ovary	other; neoplasm	Substitution - Missense
c.158C>G; p.S53C; 2:160196404-160196404	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1781G>A; p.R594H; 2:160126481-160126481	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.583A>G; p.N195D; 2:160195379-160195379	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.239C>T; p.S80F; 2:160196323-160196323	skin	malignant_melanoma	Substitution - Missense
c.1635G>T; p.V545V; 2:160137459-160137459	breast	carcinoma	Substitution - coding silent
c.1910C>T; p.A637V; 2:160123862-160123862	breast	carcinoma	Substitution - Missense
c.2344G>A; p.V782I; 2:160101759-160101759	breast	carcinoma	Substitution - Missense
c.552T>C; p.P184P; 2:160195410-160195410	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1754C>T; p.S585F; 2:160126508-160126508	breast	carcinoma	Substitution - Missense
c.1247C>T; p.S416F; 2:160137847-160137847	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1247C>T; p.S416F; 2:160137847-160137847	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1656C>T; p.C552C; 2:160137438-160137438	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1490T>C; p.L497P; 2:160137604-160137604	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2215C>T; p.R739C; 2:160107732-160107732	liver	carcinoma	Substitution - Missense
c.2215C>T; p.R739C; 2:160107732-160107732	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2215C>T; p.R739C; 2:160107732-160107732	skin	malignant_melanoma	Substitution - Missense
c.2215C>T; p.R739C; 2:160107732-160107732	skin	malignant_melanoma	Substitution - Missense
c.2215C>T; p.R739C; 2:160107732-160107732	skin	malignant_melanoma	Substitution - Missense
c.1632C>T; p.C544C; 2:160137462-160137462	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1632C>T; p.C544C; 2:160137462-160137462	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1532G>A; p.C511Y; 2:160137562-160137562	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2215C>T; p.R739C; 2:160107732-160107732	skin	malignant_melanoma	Substitution - Missense
c.2215C>T; p.R739C; 2:160107732-160107732	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.1916G>A; p.G639D; 2:160123856-160123856	breast	carcinoma	Substitution - Missense
c.886G>A; p.D296N; 2:160172604-160172604	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.922-1G>A; p.?; 2:160169308-160169308	skin	malignant_melanoma	Unknown
c.2073A>T; p.K691N; 2:160112108-160112108	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.696T>G; p.I232M; 2:160174037-160174037	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2242G>C; p.E748Q; 2:160107705-160107705	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1925G>A; p.R642Q; 2:160123847-160123847	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.1825G>T; p.A609S; 2:160126437-160126437	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1212G>T; p.K404N; 2:160138095-160138095	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.584A>G; p.N195S; 2:160195378-160195378	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.708T>C; p.I236I; 2:160174025-160174025	liver	carcinoma	Substitution - coding silent
c.2133C>T; p.I711I; 2:160107814-160107814	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.608T>A; p.F203Y; 2:160174125-160174125	liver	carcinoma	Substitution - Missense
c.1327G>A; p.A443T; 2:160137767-160137767	pancreas	carcinoma	Substitution - Missense
c.583A>T; p.N195Y; 2:160195379-160195379	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.314C>T; p.A105V; 2:160196248-160196248	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.285G>T; p.Q95H; 2:160196277-160196277	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.570A>C; p.P190P; 2:160195392-160195392	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.169G>A; p.E57K; 2:160196393-160196393	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.856G>A; p.V286I; 2:160172634-160172634	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1753T>C; p.S585P; 2:160126509-160126509	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2120A>T; p.N707I; 2:160107827-160107827	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.941A>G; p.Q314R; 2:160169288-160169288	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.268C>G; p.L90V; 2:160196294-160196294	pancreas	other; adenoma	Substitution - Missense
c.921G>T; p.L307F; 2:160172569-160172569	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1227G>A; p.M409I; 2:160138080-160138080	skin	malignant_melanoma	Substitution - Missense
c.1227G>A; p.M409I; 2:160138080-160138080	skin	malignant_melanoma	Substitution - Missense
c.1362C>T; p.C454C; 2:160137732-160137732	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2135T>C; p.M712T; 2:160107812-160107812	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1826C>T; p.A609V; 2:160126436-160126436	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.81T>C; p.G27G; 2:160199239-160199239	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.811G>A; p.D271N; 2:160172679-160172679	skin	malignant_melanoma	Substitution - Missense
c.1324G>A; p.D442N; 2:160137770-160137770	skin	malignant_melanoma	Substitution - Missense
c.1116delG; p.S373fs*8; 2:160138191-160138191	liver	carcinoma	Deletion - Frameshift
c.876C>T; p.L292L; 2:160172614-160172614	skin	malignant_melanoma	Substitution - coding silent
c.712A>C; p.T238P; 2:160174021-160174021	ovary	other; neoplasm	Substitution - Missense
c.1669G>T; p.D557Y; 2:160126593-160126593	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.718G>A; p.E240K; 2:160174015-160174015	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.515T>C; p.L172P; 2:160195447-160195447	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1257G>A; p.V419V; 2:160137837-160137837	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1734C>A; p.T578T; 2:160126528-160126528	liver	carcinoma	Substitution - coding silent
c.1734C>A; p.T578T; 2:160126528-160126528	liver	carcinoma	Substitution - coding silent
c.2301T>C; p.S767S; 2:160101802-160101802	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1826C>A; p.A609D; 2:160126436-160126436	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.551C>T; p.P184L; 2:160195411-160195411	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.760G>A; p.E254K; 2:160172730-160172730	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.431C>T; p.S144F; 2:160195531-160195531	skin	malignant_melanoma	Substitution - Missense
c.1817A>G; p.N606S; 2:160126445-160126445	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1817A>G; p.N606S; 2:160126445-160126445	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.269T>A; p.L90H; 2:160196293-160196293	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1057C>T; p.L353F; 2:160142032-160142032	central_nervous_system; brain	glioma	Substitution - Missense
c.1953A>G; p.L651L; 2:160123819-160123819	pancreas	carcinoma	Substitution - coding silent
c.1953A>G; p.L651L; 2:160123819-160123819	pancreas	carcinoma	Substitution - coding silent
c.1953A>G; p.L651L; 2:160123819-160123819	pancreas	carcinoma	Substitution - coding silent
c.2140G>A; p.G714R; 2:160107807-160107807	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.427G>A; p.A143T; 2:160195535-160195535	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1409G>A; p.G470E; 2:160137685-160137685	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1756G>A; p.E586K; 2:160126506-160126506	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2313T>C; p.N771N; 2:160101790-160101790	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1180T>A; p.C394S; 2:160138127-160138127	liver	carcinoma	Substitution - Missense
c.1180T>A; p.C394S; 2:160138127-160138127	liver	carcinoma	Substitution - Missense
c.142-1G>A; p.?; 2:160196421-160196421	skin	malignant_melanoma	Unknown
c.590G>A; p.C197Y; 2:160195372-160195372	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1212G>C; p.K404N; 2:160138095-160138095	breast	carcinoma	Substitution - Missense
c.253C>A; p.L85I; 2:160196309-160196309	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1223A>G; p.H408R; 2:160138084-160138084	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.717C>G; p.P239P; 2:160174016-160174016	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - coding silent
c.717C>G; p.P239P; 2:160174016-160174016	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - coding silent
c.1443C>T; p.C481C; 2:160137651-160137651	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation