lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3604
Symbol	TNFRSF9
Synonymous	4-1BB\|CD137\|CDw137\|ILA
Full name	tumor necrosis factor receptor superfamily, member 9
Gene description	4-1BB ligand receptor\|CD137 antigen\|T cell antigen ILA\|T-cell antigen 4-1BB homolog\|T-cell antigen ILA\|homolog of mouse 4-1BB\|induced by lymphocyte activation (ILA)\|interleukin-activated receptor, homolog of mouse Ly63\|receptor protein 4-1BB\|tumor necrosi
Cytoband	1p36
Gene type	protein-coding
Synonymous	MIM:602250; HGNC:HGNC:11924; Ensembl:ENSG00000049249; HPRD:03767

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.208G>T; p.G70C; 1:7938721-7938721	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.208G>T; p.G70C; 1:7938721-7938721	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.208G>T; p.G70C; 1:7938721-7938721	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.125A>C; p.N42T; 1:7938804-7938804	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.749A>G; p.E250G; 1:7920854-7920854	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.749A>G; p.E250G; 1:7920854-7920854	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.749A>G; p.E250G; 1:7920854-7920854	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.749A>G; p.E250G; 1:7920854-7920854	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.749A>G; p.E250G; 1:7920854-7920854	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.172G>A; p.G58R; 1:7938757-7938757	skin	malignant_melanoma	Substitution - Missense
c.345delA; p.G116fs*33; 1:7938194-7938194	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.345delA; p.G116fs*33; 1:7938194-7938194	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.225G>A; p.R75R; 1:7938314-7938314	skin	malignant_melanoma	Substitution - coding silent
c.379G>A; p.D127N; 1:7937724-7937724	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.379G>A; p.D127N; 1:7937724-7937724	skin	malignant_melanoma	Substitution - Missense
c.513T>C; p.S171S; 1:7935044-7935044	skin	malignant_melanoma	Substitution - coding silent
c.751G>A; p.G251R; 1:7920852-7920852	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.453G>A; p.T151T; 1:7935104-7935104	pancreas	carcinoma	Substitution - coding silent
c.555G>A; p.P185P; 1:7933286-7933286	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.750A>G; p.E250E; 1:7920853-7920853	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.750A>G; p.E250E; 1:7920853-7920853	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.346G>A; p.G116S; 1:7938193-7938193	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.593C>T; p.A198V; 1:7933248-7933248	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.747A>C; p.E249D; 1:7920856-7920856	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.679+7T>G; p.?; 1:7933155-7933155	liver	carcinoma	Unknown
c.679+7T>G; p.?; 1:7933155-7933155	liver	carcinoma	Unknown
c.620C>T; p.T207M; 1:7933221-7933221	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.166G>A; p.A56T; 1:7938763-7938763	central_nervous_system; brain	glioma	Substitution - Missense
c.620C>T; p.T207M; 1:7933221-7933221	urinary_tract; bladder	carcinoma	Substitution - Missense
c.88A>G; p.N30D; 1:7939907-7939907	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.234T>C; p.C78C; 1:7938305-7938305	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.647_648insG; p.R217fs*26; 1:7933193-7933194	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.92G>A; p.C31Y; 1:7939903-7939903	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.512C>A; p.S171Y; 1:7935045-7935045	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.51C>T; p.N17N; 1:7939944-7939944	skin	malignant_melanoma	Substitution - coding silent
c.331G>T; p.E111*; 1:7938208-7938208	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.654G>T; p.K218N; 1:7933187-7933187	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.194G>A; p.C65Y; 1:7938735-7938735	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.354A>C; p.K118N; 1:7937749-7937749	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.594G>A; p.A198A; 1:7933247-7933247	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.594G>A; p.A198A; 1:7933247-7933247	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2T>C; p.M1T; 1:7939993-7939993	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; chronic_myeloid_leukaemia	Substitution - Missense
c.69A>G; p.S23S; 1:7939926-7939926	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.489C>T; p.A163A; 1:7935068-7935068	breast	carcinoma	Substitution - coding silent
c.413+1G>A; p.?; 1:7937689-7937689	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.731G>A; p.R244Q; 1:7920872-7920872	breast	carcinoma	Substitution - Missense
c.575T>C; p.L192P; 1:7933266-7933266	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.624C>T; p.L208L; 1:7933217-7933217	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.679+1G>C; p.?; 1:7933161-7933161	lung	carcinoma; adenocarcinoma	Unknown
c.432G>A; p.K144K; 1:7935125-7935125	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.500C>T; p.P167L; 1:7935057-7935057	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.500C>T; p.P167L; 1:7935057-7935057	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.500C>T; p.P167L; 1:7935057-7935057	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.416G>T; p.C139F; 1:7935141-7935141	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.643C>T; p.R215W; 1:7933198-7933198	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.643C>T; p.R215W; 1:7933198-7933198	urinary_tract; bladder	carcinoma	Substitution - Missense
c.57G>C; p.E19D; 1:7939938-7939938	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.643C>T; p.R215W; 1:7933198-7933198	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.452C>T; p.T151M; 1:7935105-7935105	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.395T>A; p.I132N; 1:7937708-7937708	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.588G>A; p.S196S; 1:7933253-7933253	prostate	adenoma	Substitution - coding silent
c.588G>A; p.S196S; 1:7933253-7933253	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.626G>A; p.R209H; 1:7933215-7933215	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.547C>A; p.H183N; 1:7933294-7933294	skin; neck	malignant_melanoma	Substitution - Missense
c.501G>T; p.P167P; 1:7935056-7935056	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.428G>A; p.G143E; 1:7935129-7935129	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.485C>T; p.P162L; 1:7935072-7935072	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.729C>A; p.C243*; 1:7920874-7920874	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.171T>C; p.G57G; 1:7938758-7938758	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.502G>A; p.G168R; 1:7935055-7935055	skin	malignant_melanoma	Substitution - Missense
c.679C>T; p.P227S; 1:7933162-7933162	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.430A>T; p.K144*; 1:7935127-7935127	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.670_671insATAT; p.F224fs*20; 1:7933170-7933171	breast	carcinoma	Insertion - Frameshift
c.167C>T; p.A56V; 1:7938762-7938762	pancreas	carcinoma	Substitution - Missense
c.167C>T; p.A56V; 1:7938762-7938762	pancreas	carcinoma	Substitution - Missense
c.167C>T; p.A56V; 1:7938762-7938762	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.401G>A; p.R134Q; 1:7937702-7937702	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.26T>A; p.V9E; 1:7939969-7939969	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.736C>T; p.P246S; 1:7920867-7920867	skin	malignant_melanoma	Substitution - Missense
c.736C>T; p.P246S; 1:7920867-7920867	skin	malignant_melanoma	Substitution - Missense
c.736C>T; p.P246S; 1:7920867-7920867	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.160T>C; p.S54P; 1:7938769-7938769	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.239C>G; p.S80C; 1:7938300-7938300	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.676C>T; p.Q226*; 1:7933165-7933165	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.434C>A; p.S145Y; 1:7935123-7935123	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.137G>A; p.S46N; 1:7938792-7938792	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.450G>A; p.G150G; 1:7935107-7935107	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.413A>C; p.N138T; 1:7937690-7937690	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.192_193delAT; p.I64fs*5; 1:7938736-7938737	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.457G>A; p.E153K; 1:7935100-7935100	skin	malignant_melanoma	Substitution - Missense
c.457G>A; p.E153K; 1:7935100-7935100	skin	malignant_melanoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation