lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3559
Symbol	IL2RA
Synonymous	CD25\|IDDM10\|IL2R\|TCGFR\|p55
Full name	interleukin 2 receptor, alpha
Gene description	IL-2 receptor subunit alpha\|IL-2R subunit alpha\|TAC antigen\|interleukin-2 receptor subunit alpha
Cytoband	10p15-p14
Gene type	protein-coding
Synonymous	MIM:147730; HGNC:HGNC:6008; Ensembl:ENSG00000134460; HPRD:00986; Vega:OTTHUMG00000017616

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.54C>A; p.G18G; 10:6062098-6062098	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.167G>A; p.R56H; 10:6025923-6025923	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.765C>T; p.L255L; 10:6018082-6018082	skin	malignant_melanoma	Substitution - coding silent
c.636C>T; p.S212S; 10:6019889-6019889	skin	malignant_melanoma	Substitution - coding silent
c.636C>T; p.S212S; 10:6019889-6019889	skin	malignant_melanoma	Substitution - coding silent
c.539C>T; p.P180L; 10:6021522-6021522	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.90G>T; p.E30D; 10:6026000-6026000	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.206G>A; p.G69E; 10:6025884-6025884	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.206G>A; p.G69E; 10:6025884-6025884	skin	malignant_melanoma	Substitution - Missense
c.510G>A; p.M170I; 10:6021551-6021551	skin	malignant_melanoma	Substitution - Missense
c.420T>C; p.Y140Y; 10:6021641-6021641	liver	carcinoma	Substitution - coding silent
c.88G>A; p.E30K; 10:6026002-6026002	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.420T>C; p.Y140Y; 10:6021641-6021641	liver	carcinoma	Substitution - coding silent
c.526A>G; p.R176G; 10:6021535-6021535	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.526A>G; p.R176G; 10:6021535-6021535	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.426C>T; p.F142F; 10:6021635-6021635	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.426C>T; p.F142F; 10:6021635-6021635	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.426C>T; p.F142F; 10:6021635-6021635	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.426C>T; p.F142F; 10:6021635-6021635	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.56G>A; p.C19Y; 10:6062096-6062096	urinary_tract; bladder	carcinoma	Substitution - Missense
c.426C>T; p.F142F; 10:6021635-6021635	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.643G>T; p.V215F; 10:6019882-6019882	breast	carcinoma	Substitution - Missense
c.433G>T; p.G145W; 10:6021628-6021628	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.385C>T; p.P129S; 10:6021676-6021676	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.307delG; p.E103fs*68; 10:6024304-6024304	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.794+8T>C; p.?; 10:6018045-6018045	liver	carcinoma	Unknown
c.141G>A; p.L47L; 10:6025949-6025949	skin	malignant_melanoma	Substitution - coding silent
c.527G>A; p.R176K; 10:6021534-6021534	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.518G>A; p.G173E; 10:6021543-6021543	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.696G>A; p.T232T; 10:6019459-6019459	central_nervous_system; brain	glioma	Substitution - coding silent
c.256G>C; p.A86P; 10:6025834-6025834	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.39C>T; p.F13F; 10:6062113-6062113	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.482G>C; p.R161T; 10:6021579-6021579	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.263G>T; p.R88L; 10:6024348-6024348	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.516C>T; p.H172H; 10:6021545-6021545	breast	carcinoma	Substitution - coding silent
c.717C>A; p.Y239*; 10:6019438-6019438	skin; arm	malignant_melanoma	Substitution - Nonsense
c.689T>C; p.M230T; 10:6019466-6019466	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.165C>A; p.F55L; 10:6025925-6025925	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.170G>C; p.R57T; 10:6025920-6025920	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.93C>A; p.I31I; 10:6025997-6025997	liver	carcinoma	Substitution - coding silent
c.93C>A; p.I31I; 10:6025997-6025997	liver	carcinoma	Substitution - coding silent
c.426C>G; p.F142L; 10:6021635-6021635	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.221C>T; p.S74L; 10:6025869-6025869	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.601G>T; p.A201S; 10:6019924-6019924	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.392_393GG>AA; p.W131*; 10:6021668-6021669	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.564G>A; p.M188I; 10:6021497-6021497	skin	malignant_melanoma	Substitution - Missense
c.99C>T; p.H33H; 10:6025991-6025991	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.608C>T; p.P203L; 10:6019917-6019917	skin	malignant_melanoma	Substitution - Missense
c.616C>T; p.R206C; 10:6019909-6019909	skin	malignant_melanoma	Substitution - Missense
c.8C>G; p.S3*; 10:6062144-6062144	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.214A>G; p.S72G; 10:6025876-6025876	breast	carcinoma	Substitution - Missense
c.574C>A; p.Q192K; 10:6021487-6021487	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.757G>A; p.V253I; 10:6018090-6018090	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.686C>A; p.T229N; 10:6019469-6019469	large_intestine; colon	carcinoma	Substitution - Missense
c.686C>A; p.T229N; 10:6019469-6019469	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.750G>C; p.L250L; 10:6018097-6018097	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.610G>A; p.E204K; 10:6019915-6019915	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.610G>A; p.E204K; 10:6019915-6019915	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.599A>C; p.Q200P; 10:6019926-6019926	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.610G>A; p.E204K; 10:6019915-6019915	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.251G>A; p.S84N; 10:6025839-6025839	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.180C>T; p.S60S; 10:6025910-6025910	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.130G>T; p.G44*; 10:6025960-6025960	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.682G>T; p.A228S; 10:6019473-6019473	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.166C>T; p.R56C; 10:6025924-6025924	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.580C>T; p.P194S; 10:6021481-6021481	skin	malignant_melanoma	Substitution - Missense
c.457G>A; p.V153I; 10:6021604-6021604	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.456C>A; p.C152*; 10:6021605-6021605	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.357G>T; p.A119A; 10:6024254-6024254	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.367+7G>C; p.?; 10:6024237-6024237	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.808A>C; p.R270R; 10:6012883-6012883	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.617G>A; p.R206H; 10:6019908-6019908	thyroid	carcinoma	Substitution - Missense
c.127G>A; p.E43K; 10:6025963-6025963	skin; mucosal	malignant_melanoma	Substitution - Missense
c.493G>T; p.E165*; 10:6021568-6021568	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Nonsense
c.493G>T; p.E165*; 10:6021568-6021568	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.276A>G; p.K92K; 10:6024335-6024335	skin	malignant_melanoma	Substitution - coding silent
c.499G>A; p.V167I; 10:6021562-6021562	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.499G>A; p.V167I; 10:6021562-6021562	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.273G>A; p.T91T; 10:6024338-6024338	skin	malignant_melanoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation