Cancer metastasis database

Annotation category 5

Gene information

Gene ID 3557
Symbol

IL1RN

Synonymous

DIRA|ICIL-1RA|IL-1RN|IL-1ra|IL-1ra3|IL1F3|IL1RA|IRAP|MVCD4

Full name

interleukin 1 receptor antagonist

Gene description

IL1 inhibitor|IL1RN (IL1F3)|interleukin-1 receptor antagonist protein|intracellular IL-1 receptor antagonist type II|intracellular interleukin-1 receptor antagonist (icIL-1ra)|type II interleukin-1 receptor antagonist

Cytoband

2q14.2

Gene type

protein-coding

Synonymous

MIM:147679; HGNC:HGNC:6000; Ensembl:ENSG00000136689; HPRD:00978; Vega:OTTHUMG00000131341

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.400G>A; p.V134I; 2:113132839-113132839

 skinmalignant_melanomaSubstitution - Missense

c.289G>A; p.G97S; 2:113132728-113132728

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.196G>A; p.E66K; 2:113131137-113131137

 breastcarcinomaSubstitution - Missense

c.388G>A; p.E130K; 2:113132827-113132827

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.263G>A; p.R88H; 2:113132702-113132702

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.431A>G; p.*144W; 2:113132870-113132870

 central_nervous_system; brainstemglioma; astrocytoma_Grade_IINonstop extension

c.100G>T; p.E34*; 2:113129661-113129661

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Nonsense

c.138T>C; p.A46A; 2:113131079-113131079

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.417C>T; p.F139F; 2:113132856-113132856

 skinmalignant_melanomaSubstitution - coding silent

c.20G>T; p.W7L; 2:113129581-113129581

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.173T>C; p.L58P; 2:113131114-113131114

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.69T>C; p.A23A; 2:113129630-113129630

 livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.284A>T; p.D95V; 2:113132723-113132723

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.421G>A; p.E141K; 2:113132860-113132860

 skinmalignant_melanomaSubstitution - Missense

c.314C>A; p.A105D; 2:113132753-113132753

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.206T>G; p.L69R; 2:113131147-113131147

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.281C>T; p.S94L; 2:113132720-113132720

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.333C>T; p.F111F; 2:113132772-113132772

 skinmalignant_melanomaSubstitution - coding silent

c.278G>A; p.R93H; 2:113132717-113132717

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.268G>A; p.A90T; 2:113132707-113132707

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.268G>A; p.A90T; 2:113132707-113132707

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.268G>A; p.A90T; 2:113132707-113132707

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.149G>A; p.G50E; 2:113131090-113131090

 skin; mucosalmalignant_melanomaSubstitution - Missense

c.31C>T; p.Q11*; 2:113129592-113129592

 skinmalignant_melanomaSubstitution - Nonsense

c.83G>A; p.G28E; 2:113129644-113129644

 skinmalignant_melanomaSubstitution - Missense

c.376A>G; p.N126D; 2:113132815-113132815

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.392G>A; p.G131D; 2:113132831-113132831

 skinmalignant_melanomaSubstitution - Missense

c.186G>T; p.K62N; 2:113131127-113131127

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.190G>T; p.G64C; 2:113131131-113131131

 breastcarcinomaSubstitution - Missense

c.331T>G; p.F111V; 2:113132770-113132770

 skin; upper_legmalignant_melanomaSubstitution - Missense

c.162G>T; p.G54G; 2:113131103-113131103

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.264C>T; p.R88R; 2:113132703-113132703

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1-14615G>A; p.?; 2:113113112-113113112

 skinmalignant_melanomaUnknown