lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3485
Symbol	IGFBP2
Synonymous	IBP2\|IGF-BP53
Full name	insulin-like growth factor binding protein 2, 36kDa
Gene description	IBP-2\|IGF-binding protein 2\|IGFBP-2\|insulin-like growth factor-binding protein 2
Cytoband	2q35
Gene type	protein-coding
Synonymous	MIM:146731; HGNC:HGNC:5471; Ensembl:ENSG00000115457; HPRD:00898; Vega:OTTHUMG00000155341

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.513C>T; p.G171G; 2:216660627-216660627	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.568G>A; p.V190M; 2:216660682-216660682	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.797T>C; p.L266P; 2:216661982-216661982	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.502A>G; p.N168D; 2:216660616-216660616	skin	malignant_melanoma	Substitution - Missense
c.774C>T; p.I258I; 2:216661959-216661959	skin	malignant_melanoma	Substitution - coding silent
c.577G>A; p.E193K; 2:216660691-216660691	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.599G>A; p.R200Q; 2:216660713-216660713	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.566C>T; p.A189V; 2:216660680-216660680	urinary_tract; bladder	carcinoma	Substitution - Missense
c.566C>T; p.A189V; 2:216660680-216660680	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.514G>A; p.G172R; 2:216660628-216660628	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.951C>A; p.R317R; 2:216664077-216664077	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.724C>T; p.R242C; 2:216661909-216661909	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.603G>C; p.Q201H; 2:216660717-216660717	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.939G>A; p.Q313Q; 2:216664065-216664065	stomach	adenocarcinoma	Substitution - coding silent
c.344C>T; p.P115L; 2:216633867-216633867	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.871G>A; p.G291R; 2:216663997-216663997	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.871G>A; p.G291R; 2:216663997-216663997	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.522C>T; p.G174G; 2:216660636-216660636	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.901C>T; p.R301W; 2:216664027-216664027	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.901C>T; p.R301W; 2:216664027-216664027	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.723G>C; p.M241I; 2:216661908-216661908	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.832G>A; p.G278R; 2:216663958-216663958	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.971T>C; p.M324T; 2:216664097-216664097	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.709C>T; p.R237W; 2:216661894-216661894	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.324G>A; p.G108G; 2:216633847-216633847	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.514delG; p.G173fs*13; 2:216660628-216660628	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.514delG; p.G173fs*13; 2:216660628-216660628	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.732G>A; p.P244P; 2:216661917-216661917	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.775C>T; p.P259S; 2:216661960-216661960	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.766C>A; p.L256M; 2:216661951-216661951	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.526G>T; p.A176S; 2:216660640-216660640	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.526G>T; p.A176S; 2:216660640-216660640	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.740G>T; p.R247L; 2:216661925-216661925	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.387C>T; p.G129G; 2:216633910-216633910	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.387C>T; p.G129G; 2:216633910-216633910	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.822G>A; p.M274I; 2:216663948-216663948	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.919C>T; p.H307Y; 2:216664045-216664045	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.65T>C; p.L22P; 2:216633588-216633588	liver	carcinoma	Substitution - Missense
c.65T>C; p.L22P; 2:216633588-216633588	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Missense
c.59T>C; p.L20P; 2:216633582-216633582	pancreas	carcinoma	Substitution - Missense
c.59T>C; p.L20P; 2:216633582-216633582	liver	carcinoma	Substitution - Missense
c.532C>T; p.R178W; 2:216660646-216660646	central_nervous_system; brain	glioma	Substitution - Missense
c.487G>A; p.V163M; 2:216660601-216660601	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.838C>T; p.R280C; 2:216663964-216663964	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.659C>T; p.P220L; 2:216660773-216660773	skin	malignant_melanoma	Substitution - Missense
c.584T>C; p.V195A; 2:216660698-216660698	pancreas	carcinoma	Substitution - Missense
c.655C>T; p.R219*; 2:216660769-216660769	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.905G>T; p.G302V; 2:216664031-216664031	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.72A>G; p.L24L; 2:216633595-216633595	liver	carcinoma	Substitution - coding silent
c.72A>G; p.L24L; 2:216633595-216633595	liver	carcinoma	Substitution - coding silent
c.72A>G; p.L24L; 2:216633595-216633595	liver	carcinoma	Substitution - coding silent
c.72A>G; p.L24L; 2:216633595-216633595	liver	carcinoma	Substitution - coding silent
c.72A>G; p.L24L; 2:216633595-216633595	liver	carcinoma	Substitution - coding silent
c.568G>T; p.V190L; 2:216660682-216660682	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.563T>C; p.L188P; 2:216660677-216660677	breast	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation