lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3455
Symbol	IFNAR2
Synonymous	IFN-R\|IFN-alpha-REC\|IFNABR\|IFNARB
Full name	interferon (alpha, beta and omega) receptor 2
Gene description	IFN-R-2\|IFN-alpha/beta receptor 2\|human interferon alpha/beta receptor\|interferon alpha binding protein\|interferon alpha/beta receptor 2\|interferon-alpha/beta receptor beta chain\|type I interferon receptor 2
Cytoband	21q22.11
Gene type	protein-coding
Synonymous	MIM:602376; HGNC:HGNC:5433; Ensembl:ENSG00000159110; HPRD:03850; Vega:OTTHUMG00000065127

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1516G>A; p.V506I; 21:33263468-33263468	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.772A>G; p.T258A; 21:33260659-33260659	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.364T>C; p.C122R; 21:33246860-33246860	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.850A>T; p.N284Y; 21:33262802-33262802	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.456G>T; p.V152V; 21:33248770-33248770	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.806A>G; p.Y269C; 21:33260693-33260693	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1376C>A; p.P459Q; 21:33263328-33263328	skin	malignant_melanoma	Substitution - Missense
c.1342A>C; p.M448L; 21:33263294-33263294	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1257C>A; p.G419G; 21:33263209-33263209	oesophagus	carcinoma	Substitution - coding silent
c.577T>G; p.F193V; 21:33252698-33252698	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1066G>C; p.E356Q; 21:33263018-33263018	ovary	other; neoplasm	Substitution - Missense
c.1324G>A; p.D442N; 21:33263276-33263276	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.628G>T; p.V210F; 21:33252749-33252749	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1067A>G; p.E356G; 21:33263019-33263019	pancreas	carcinoma	Substitution - Missense
c.971G>T; p.S324I; 21:33262923-33262923	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.917A>C; p.Y306S; 21:33262869-33262869	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.398C>G; p.S133C; 21:33248712-33248712	urinary_tract; bladder	carcinoma	Substitution - Missense
c.423T>A; p.I141I; 21:33248737-33248737	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.1548A>G; p.*516W; 21:33263500-33263500	endometrium	carcinoma; endometrioid_carcinoma	Nonstop extension
c.1548A>G; p.*516W; 21:33263500-33263500	endometrium	carcinoma; endometrioid_carcinoma	Nonstop extension
c.143T>A; p.F48Y; 21:33244996-33244996	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.846T>C; p.F282F; 21:33262798-33262798	skin	malignant_melanoma	Substitution - coding silent
c.93G>A; p.S31S; 21:33243710-33243710	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.588C>G; p.I196M; 21:33252709-33252709	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.126G>T; p.K42N; 21:33244979-33244979	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.315C>T; p.A105A; 21:33246811-33246811	skin	malignant_melanoma	Substitution - coding silent
c.1315G>A; p.D439N; 21:33263267-33263267	breast	carcinoma	Substitution - Missense
c.1315G>A; p.D439N; 21:33263267-33263267	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.137G>A; p.R46Q; 21:33244990-33244990	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.137G>A; p.R46Q; 21:33244990-33244990	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.28T>G; p.F10V; 21:33241950-33241950	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.28T>G; p.F10V; 21:33241950-33241950	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.28T>G; p.F10V; 21:33241950-33241950	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.285C>T; p.L95L; 21:33246781-33246781	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1052C>T; p.S351F; 21:33263004-33263004	skin	malignant_melanoma	Substitution - Missense
c.167_168insA; p.N58fs*18; 21:33245020-33245021	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.386C>T; p.A129V; 21:33246882-33246882	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.23T>C; p.F8S; 21:33241945-33241945	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.942G>A; p.W314*; 21:33262894-33262894	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1312G>A; p.E438K; 21:33263264-33263264	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1312G>A; p.E438K; 21:33263264-33263264	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1312G>A; p.E438K; 21:33263264-33263264	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.493G>C; p.D165H; 21:33248807-33248807	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.240G>A; p.K80K; 21:33246736-33246736	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.781A>T; p.I261L; 21:33260668-33260668	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.353C>T; p.T118M; 21:33246849-33246849	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.909G>T; p.E303D; 21:33262861-33262861	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1420G>A; p.G474R; 21:33263372-33263372	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1420G>A; p.G474R; 21:33263372-33263372	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1363G>A; p.E455K; 21:33263315-33263315	skin	malignant_melanoma	Substitution - Missense
c.465A>T; p.P155P; 21:33248779-33248779	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.504C>T; p.L168L; 21:33248818-33248818	skin	malignant_melanoma	Substitution - coding silent
c.768C>A; p.V256V; 21:33260655-33260655	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.768C>A; p.V256V; 21:33260655-33260655	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.668C>T; p.S223F; 21:33252789-33252789	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1544G>A; p.R515K; 21:33263496-33263496	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.344G>A; p.G115E; 21:33246840-33246840	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.302G>A; p.S101N; 21:33246798-33246798	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1238_1239CC>TT; p.S413F; 21:33263190-33263191	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1286C>T; p.S429F; 21:33263238-33263238	skin	malignant_melanoma	Substitution - Missense
c.341G>A; p.S114N; 21:33246837-33246837	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1470G>A; p.W490*; 21:33263422-33263422	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1349C>T; p.S450L; 21:33263301-33263301	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1349C>T; p.S450L; 21:33263301-33263301	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1225G>C; p.E409Q; 21:33263177-33263177	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.930G>C; p.K310N; 21:33262882-33262882	thyroid	carcinoma	Substitution - Missense
c.1003G>A; p.G335S; 21:33262955-33262955	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.693A>C; p.P231P; 21:33252814-33252814	breast	carcinoma	Substitution - coding silent
c.216C>T; p.I72I; 21:33245069-33245069	skin	malignant_melanoma	Substitution - coding silent
c.780C>G; p.T260T; 21:33260667-33260667	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.597G>A; p.K199K; 21:33252718-33252718	central_nervous_system; brain	glioma	Substitution - coding silent
c.1242G>A; p.T414T; 21:33263194-33263194	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1432C>T; p.Q478*; 21:33263384-33263384	breast	carcinoma	Substitution - Nonsense
c.847C>T; p.H283Y; 21:33262799-33262799	skin	malignant_melanoma	Substitution - Missense
c.841-1G>A; p.?; 21:33262792-33262792	prostate	carcinoma; adenocarcinoma	Unknown
c.1022_1025delGACT; p.T343fs*16; 21:33262974-33262977	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.261T>A; p.N87K; 21:33246757-33246757	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.762A>G; p.A254A; 21:33260649-33260649	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1271A>T; p.N424I; 21:33263223-33263223	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.132A>G; p.S44S; 21:33244985-33244985	breast	carcinoma	Substitution - coding silent
c.1398A>G; p.Q466Q; 21:33263350-33263350	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.841-4T>A; p.?; 21:33262789-33262789	liver	carcinoma	Unknown
c.464C>T; p.P155L; 21:33248778-33248778	skin	malignant_melanoma	Substitution - Missense
c.1333G>A; p.A445T; 21:33263285-33263285	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.204G>A; p.L68L; 21:33245057-33245057	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.1137G>A; p.T379T; 21:33263089-33263089	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1105G>A; p.D369N; 21:33263057-33263057	pancreas	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation