lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3381
Symbol	IBSP
Synonymous	BNSP\|BSP\|BSP-II\|SP-II
Full name	integrin-binding sialoprotein
Gene description	BSP II\|bone sialoprotein 2\|bone sialoprotein II\|cell-binding sialoprotein
Cytoband	4q21.1
Gene type	protein-coding
Synonymous	MIM:147563; HGNC:HGNC:5341; Ensembl:ENSG00000029559; HPRD:00951; Vega:OTTHUMG00000130600

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.570C>T; p.N190N; 4:87811526-87811526	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.313A>G; p.T105A; 4:87810672-87810672	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.558A>G; p.A186A; 4:87811514-87811514	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.516C>T; p.N172N; 4:87811472-87811472	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.170G>A; p.R57Q; 4:87802718-87802718	ovary	carcinoma	Substitution - Missense
c.912C>T; p.G304G; 4:87811868-87811868	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.256A>G; p.N86D; 4:87810615-87810615	breast	carcinoma	Substitution - Missense
c.71G>A; p.R24Q; 4:87802524-87802524	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.133C>A; p.L45I; 4:87802681-87802681	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.71G>A; p.R24Q; 4:87802524-87802524	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.71G>A; p.R24Q; 4:87802524-87802524	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.621T>G; p.T207T; 4:87811577-87811577	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.457G>A; p.E153K; 4:87811413-87811413	skin	malignant_melanoma	Substitution - Missense
c.201C>T; p.S67S; 4:87806139-87806139	pancreas	carcinoma	Substitution - coding silent
c.376G>A; p.G126R; 4:87810735-87810735	skin	malignant_melanoma	Substitution - Missense
c.532G>T; p.G178C; 4:87811488-87811488	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.449A>G; p.D150G; 4:87811405-87811405	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.476G>A; p.G159E; 4:87811432-87811432	soft_tissue; blood_vessel	angiosarcoma	Substitution - Missense
c.476G>A; p.G159E; 4:87811432-87811432	skin	malignant_melanoma	Substitution - Missense
c.675G>A; p.S225S; 4:87811631-87811631	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.127T>C; p.Y43H; 4:87802675-87802675	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.87G>T; p.E29D; 4:87802540-87802540	liver	carcinoma	Substitution - Missense
c.723A>G; p.P241P; 4:87811679-87811679	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.775T>A; p.Y259N; 4:87811731-87811731	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.3G>T; p.M1I; 4:87802364-87802364	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.326C>A; p.A109D; 4:87810685-87810685	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.821G>C; p.G274A; 4:87811777-87811777	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.565G>A; p.G189S; 4:87811521-87811521	skin	malignant_melanoma	Substitution - Missense
c.499G>A; p.A167T; 4:87811455-87811455	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.499G>A; p.A167T; 4:87811455-87811455	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.565G>A; p.G189S; 4:87811521-87811521	skin	malignant_melanoma	Substitution - Missense
c.810A>T; p.E270D; 4:87811766-87811766	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.810A>T; p.E270D; 4:87811766-87811766	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.644C>T; p.T215I; 4:87811600-87811600	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.249G>T; p.E83D; 4:87810608-87810608	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.584G>A; p.G195E; 4:87811540-87811540	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.584G>A; p.G195E; 4:87811540-87811540	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.735A>C; p.R245S; 4:87811691-87811691	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.487G>T; p.E163*; 4:87811443-87811443	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Nonsense
c.486C>T; p.N162N; 4:87811442-87811442	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.486C>T; p.N162N; 4:87811442-87811442	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.826G>A; p.E276K; 4:87811782-87811782	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.532G>A; p.G178S; 4:87811488-87811488	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.813C>T; p.Y271Y; 4:87811769-87811769	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.813C>T; p.Y271Y; 4:87811769-87811769	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.532G>A; p.G178S; 4:87811488-87811488	pancreas	carcinoma	Substitution - Missense
c.813C>T; p.Y271Y; 4:87811769-87811769	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.64T>C; p.L22L; 4:87802517-87802517	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.57G>A; p.M19I; 4:87802510-87802510	skin	malignant_melanoma	Substitution - Missense
c.41C>T; p.A14V; 4:87802402-87802402	breast	carcinoma	Substitution - Missense
c.41C>T; p.A14V; 4:87802402-87802402	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.801C>A; p.G267G; 4:87811757-87811757	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.803C>T; p.A268V; 4:87811759-87811759	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.459A>G; p.E153E; 4:87811415-87811415	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.356C>T; p.T119M; 4:87810715-87810715	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.384T>A; p.A128A; 4:87810743-87810743	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.674C>T; p.S225L; 4:87811630-87811630	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.262G>A; p.G88R; 4:87810621-87810621	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.707A>C; p.E236A; 4:87811663-87811663	urinary_tract; bladder	carcinoma	Substitution - Missense
c.898T>C; p.F300L; 4:87811854-87811854	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.379T>C; p.L127L; 4:87810738-87810738	skin	malignant_melanoma	Substitution - coding silent
c.862G>A; p.D288N; 4:87811818-87811818	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.181C>T; p.Q61*; 4:87802729-87802729	breast	carcinoma	Substitution - Nonsense
c.861G>A; p.G287G; 4:87811817-87811817	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.346G>A; p.E116K; 4:87810705-87810705	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.701G>T; p.G234V; 4:87811657-87811657	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.592G>A; p.G198R; 4:87811548-87811548	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.442G>A; p.E148K; 4:87811398-87811398	skin	malignant_melanoma	Substitution - Missense
c.402G>T; p.K134N; 4:87810761-87810761	kidney	other; neoplasm	Substitution - Missense
c.756G>A; p.G252G; 4:87811712-87811712	skin	malignant_melanoma	Substitution - coding silent
c.568A>T; p.N190Y; 4:87811524-87811524	liver	carcinoma	Substitution - Missense
c.487G>A; p.E163K; 4:87811443-87811443	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.487G>A; p.E163K; 4:87811443-87811443	skin	malignant_melanoma	Substitution - Missense
c.487G>A; p.E163K; 4:87811443-87811443	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.487G>A; p.E163K; 4:87811443-87811443	skin	malignant_melanoma	Substitution - Missense
c.814G>A; p.D272N; 4:87811770-87811770	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.517G>A; p.E173K; 4:87811473-87811473	skin	malignant_melanoma	Substitution - Missense
c.517G>A; p.E173K; 4:87811473-87811473	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.117C>T; p.Y39Y; 4:87802665-87802665	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.517G>A; p.E173K; 4:87811473-87811473	skin	malignant_melanoma	Substitution - Missense
c.618C>T; p.V206V; 4:87811574-87811574	skin	malignant_melanoma	Substitution - coding silent
c.377G>T; p.G126V; 4:87810736-87810736	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.697G>T; p.G233C; 4:87811653-87811653	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.495C>T; p.S165S; 4:87811451-87811451	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.15A>C; p.L5F; 4:87802376-87802376	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.495C>T; p.S165S; 4:87811451-87811451	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.484A>C; p.N162H; 4:87811440-87811440	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.872G>A; p.R291Q; 4:87811828-87811828	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.423T>C; p.N141N; 4:87811379-87811379	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.469G>A; p.E157K; 4:87811425-87811425	skin	malignant_melanoma	Substitution - Missense
c.746C>G; p.P249R; 4:87811702-87811702	breast	carcinoma; ductal_carcinoma	Substitution - Missense
c.250A>G; p.T84A; 4:87810609-87810609	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.62A>T; p.N21I; 4:87802515-87802515	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.263G>T; p.G88V; 4:87810622-87810622	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.715A>C; p.T239P; 4:87811671-87811671	thyroid	other; neoplasm	Substitution - Missense
c.70C>T; p.R24*; 4:87802523-87802523	breast	carcinoma	Substitution - Nonsense
c.70C>T; p.R24*; 4:87802523-87802523	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.655A>G; p.R219G; 4:87811611-87811611	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.121C>T; p.P41S; 4:87802669-87802669	breast	carcinoma	Substitution - Missense
c.841G>C; p.E281Q; 4:87811797-87811797	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.802G>A; p.A268T; 4:87811758-87811758	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.802G>A; p.A268T; 4:87811758-87811758	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.802G>A; p.A268T; 4:87811758-87811758	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.802G>A; p.A268T; 4:87811758-87811758	large_intestine; colon	carcinoma	Substitution - Missense
c.802G>A; p.A268T; 4:87811758-87811758	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.904G>A; p.G302R; 4:87811860-87811860	skin	malignant_melanoma	Substitution - Missense
c.769G>A; p.V257I; 4:87811725-87811725	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.769G>A; p.V257I; 4:87811725-87811725	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.769G>A; p.V257I; 4:87811725-87811725	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.238G>A; p.E80K; 4:87806176-87806176	skin	malignant_melanoma	Substitution - Missense
c.282G>A; p.S94S; 4:87810641-87810641	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.282G>A; p.S94S; 4:87810641-87810641	skin	malignant_melanoma	Substitution - coding silent
c.915C>T; p.Y305Y; 4:87811871-87811871	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.857G>A; p.R286H; 4:87811813-87811813	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.553G>T; p.E185*; 4:87811509-87811509	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.553G>T; p.E185*; 4:87811509-87811509	large_intestine; colon	carcinoma	Substitution - Nonsense
c.553G>T; p.E185*; 4:87811509-87811509	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.789C>T; p.Y263Y; 4:87811745-87811745	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.357G>A; p.T119T; 4:87810716-87810716	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation