Cancer metastasis database

Annotation category 5

Gene information

Gene ID 3373
Symbol

HYAL1

Synonymous

HYAL-1|LUCA1|MPS9|NAT6

Full name

hyaluronoglucosaminidase 1

Gene description

hyaluronidase-1|luCa-1|lung carcinoma protein 1|plasma hyaluronidase|tumor suppressor LUCA-1

Cytoband

3p21.31

Gene type

protein-coding

Synonymous

MIM:607071; HGNC:HGNC:5320; Ensembl:ENSG00000114378; HPRD:06146; Vega:OTTHUMG00000156941

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.392A>G; p.E131G; 3:50302565-50302565

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.394G>A; p.A132T; 3:50302563-50302563

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1233G>C; p.Q411H; 3:50300558-50300558

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.734G>C; p.S245T; 3:50302223-50302223

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.719G>A; p.R240H; 3:50302238-50302238

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.391G>A; p.E131K; 3:50302566-50302566

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.719G>A; p.R240H; 3:50302238-50302238

 pancreascarcinoma; acinar_carcinomaSubstitution - Missense

c.368C>G; p.S123*; 3:50302589-50302589

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Nonsense

c.1112G>A; p.R371H; 3:50300679-50300679

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.826G>T; p.A276S; 3:50302131-50302131

 adrenal_gland; adrenal_glandadrenal_cortical_carcinoma; functioningSubstitution - Missense

c.932C>T; p.A311V; 3:50301046-50301046

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1176G>A; p.T392T; 3:50300615-50300615

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.539G>A; p.R180Q; 3:50302418-50302418

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.543C>A; p.A181A; 3:50302414-50302414

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.1298G>A; p.S433N; 3:50300493-50300493

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.637C>A; p.L213I; 3:50302320-50302320

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.299C>T; p.A100V; 3:50302658-50302658

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.860T>A; p.V287D; 3:50302097-50302097

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.528G>T; p.Q176H; 3:50302429-50302429

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.228C>T; p.S76S; 3:50302729-50302729

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.151G>A; p.V51M; 3:50302806-50302806

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.179C>T; p.A60V; 3:50302778-50302778

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.24C>G; p.I8M; 3:50302933-50302933

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.169G>A; p.D57N; 3:50302788-50302788

 oesophaguscarcinomaSubstitution - Missense

c.1125C>T; p.H375H; 3:50300666-50300666

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasmSubstitution - coding silent

c.680C>T; p.A227V; 3:50302277-50302277

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.904G>A; p.E302K; 3:50301074-50301074

 endometriumcarcinoma; serous_carcinomaSubstitution - Missense

c.571C>T; p.R191W; 3:50302386-50302386

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1262A>G; p.Y421C; 3:50300529-50300529

 skin; anklemalignant_melanoma; acral_lentiginousSubstitution - Missense

c.240C>T; p.G80G; 3:50302717-50302717

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.972G>A; p.W324*; 3:50301006-50301006

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Nonsense

c.733A>G; p.S245G; 3:50302224-50302224

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.662G>A; p.C221Y; 3:50302295-50302295

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.676C>T; p.R226C; 3:50302281-50302281

 skinmalignant_melanomaSubstitution - Missense

c.1A>G; p.M1V; 3:50302956-50302956

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.878C>T; p.T293M; 3:50302079-50302079

 biliary_tract; gallbladdercarcinoma; adenocarcinomaSubstitution - Missense

c.721G>A; p.A241T; 3:50302236-50302236

 ovaryother; neoplasmSubstitution - Missense

c.1093G>A; p.G365S; 3:50300698-50300698

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.272C>A; p.P91H; 3:50302685-50302685

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1159T>C; p.F387L; 3:50300632-50300632

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.72C>A; p.G24G; 3:50302885-50302885

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.820G>C; p.V274L; 3:50302137-50302137

 oesophaguscarcinomaSubstitution - Missense

c.766G>A; p.G256R; 3:50302191-50302191

 breastcarcinomaSubstitution - Missense

c.766G>A; p.G256R; 3:50302191-50302191

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.347C>T; p.A116V; 3:50302610-50302610

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.424G>A; p.D142N; 3:50302533-50302533

 skinmalignant_melanomaSubstitution - Missense

c.1291C>T; p.R431W; 3:50300500-50300500

 central_nervous_system; braingliomaSubstitution - Missense

c.1219G>A; p.E407K; 3:50300572-50300572

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.943_944insG; p.A315fs*69; 3:50301034-50301035

 large_intestine; coloncarcinoma; adenocarcinomaInsertion - Frameshift

c.505_506GC>AA; p.A169>?; 3:50302451-50302452

 prostatecarcinomaComplex

c.323G>A; p.R108H; 3:50302634-50302634

 pancreascarcinoma; acinar_carcinomaSubstitution - Missense

c.33C>T; p.L11L; 3:50302924-50302924

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.901-2A>G; p.?; 3:50301079-50301079

 stomachcarcinoma; intestinal_adenocarcinomaUnknown

c.925G>A; p.E309K; 3:50301053-50301053

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.925G>A; p.E309K; 3:50301053-50301053

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.1143C>T; p.L381L; 3:50300648-50300648

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.718C>T; p.R240C; 3:50302239-50302239

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.134A>G; p.E45G; 3:50302823-50302823

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.127T>C; p.C43R; 3:50302830-50302830

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.48C>A; p.L16L; 3:50302909-50302909

 urinary_tract; bladdercarcinomaSubstitution - coding silent