lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3364
Symbol	HUS1
Synonymous	hHUS1
Full name	HUS1 checkpoint homolog (S. pombe)
Gene description	checkpoint protein HUS1\|hus1+-like protein
Cytoband	7p13-p12
Gene type	protein-coding
Synonymous	MIM:603760; HGNC:HGNC:5309; Ensembl:ENSG00000136273; HPRD:04787; Vega:OTTHUMG00000155645

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.94C>T; p.L32F; 7:47978775-47978775	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.720T>C; p.F240F; 7:47967846-47967846	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.720T>C; p.F240F; 7:47967846-47967846	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.8T>G; p.F3C; 7:47979512-47979512	urinary_tract; bladder	carcinoma	Substitution - Missense
c.546T>C; p.I182I; 7:47969313-47969313	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.95T>C; p.L32P; 7:47978774-47978774	prostate	carcinoma	Substitution - Missense
c.446C>T; p.P149L; 7:47976749-47976749	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.339C>T; p.L113L; 7:47978435-47978435	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.687A>C; p.E229D; 7:47967879-47967879	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.374G>T; p.S125I; 7:47976821-47976821	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.374G>T; p.S125I; 7:47976821-47976821	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.733C>T; p.Q245*; 7:47967833-47967833	skin	malignant_melanoma	Substitution - Nonsense
c.817C>T; p.Q273*; 7:47965382-47965382	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.718T>C; p.F240L; 7:47967848-47967848	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.718T>C; p.F240L; 7:47967848-47967848	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.718T>C; p.F240L; 7:47967848-47967848	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.718T>C; p.F240L; 7:47967848-47967848	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.718T>C; p.F240L; 7:47967848-47967848	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.439C>A; p.Q147K; 7:47976756-47976756	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.232G>A; p.E78K; 7:47978542-47978542	breast	carcinoma	Substitution - Missense
c.390C>A; p.T130T; 7:47976805-47976805	thyroid	carcinoma	Substitution - coding silent
c.471T>C; p.S157S; 7:47975682-47975682	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.325C>A; p.H109N; 7:47978449-47978449	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.834G>A; p.A278A; 7:47965365-47965365	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.87C>A; p.T29T; 7:47978782-47978782	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.768G>T; p.V256V; 7:47965431-47965431	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.464A>T; p.D155V; 7:47976731-47976731	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.592T>A; p.L198I; 7:47969267-47969267	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.192C>A; p.F64L; 7:47978582-47978582	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.501G>T; p.K167N; 7:47975652-47975652	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.387G>A; p.V129V; 7:47976808-47976808	breast	carcinoma	Substitution - coding silent
c.340A>T; p.T114S; 7:47978434-47978434	skin	malignant_melanoma	Substitution - Missense
c.719T>G; p.F240C; 7:47967847-47967847	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.715C>T; p.Q239*; 7:47967851-47967851	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.183G>T; p.E61D; 7:47978591-47978591	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.729A>T; p.G243G; 7:47967837-47967837	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.663C>T; p.D221D; 7:47967903-47967903	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.603T>C; p.V201V; 7:47969256-47969256	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.377G>C; p.S126T; 7:47976818-47976818	breast	carcinoma; lobular_carcinoma	Substitution - Missense
c.341C>T; p.T114M; 7:47978433-47978433	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.61A>G; p.N21D; 7:47978808-47978808	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.28G>T; p.G10W; 7:47979492-47979492	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.179A>C; p.Q60P; 7:47978690-47978690	ovary	other; neoplasm	Substitution - Missense
c.255G>A; p.S85S; 7:47978519-47978519	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.255G>A; p.S85S; 7:47978519-47978519	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.656A>T; p.H219L; 7:47967910-47967910	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.635C>T; p.P212L; 7:47969224-47969224	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.826A>G; p.I276V; 7:47965373-47965373	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.211G>A; p.G71S; 7:47978563-47978563	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.28G>C; p.G10R; 7:47979492-47979492	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.358-8C>T; p.?; 7:47976845-47976845	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.697G>C; p.D233H; 7:47967869-47967869	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.697G>C; p.D233H; 7:47967869-47967869	urinary_tract; bladder	carcinoma	Substitution - Missense
c.840C>G; p.S280S; 7:47965359-47965359	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.359T>G; p.L120*; 7:47976836-47976836	liver	carcinoma; hepatocellular_carcinoma	Substitution - Nonsense
c.416C>A; p.P139H; 7:47976779-47976779	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.667A>C; p.N223H; 7:47967899-47967899	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.196G>T; p.E66*; 7:47978578-47978578	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.462T>C; p.P154P; 7:47976733-47976733	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.195C>T; p.N65N; 7:47978579-47978579	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.284C>T; p.A95V; 7:47978490-47978490	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.503G>A; p.S168N; 7:47975650-47975650	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.181-8delT; p.?; 7:47978601-47978601	skin	malignant_melanoma	Unknown

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation