lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3326
Symbol	HSP90AB1
Synonymous	D6S182\|HSP84\|HSP90B\|HSPC2\|HSPCB
Full name	heat shock protein 90kDa alpha (cytosolic), class B member 1
Gene description	HSP90-beta\|heat shock 84 kDa\|heat shock 90kD protein 1, beta\|heat shock protein HSP 90-beta
Cytoband	6p12
Gene type	protein-coding
Synonymous	MIM:140572; HGNC:HGNC:5258; Ensembl:ENSG00000096384; HPRD:06763; Vega:OTTHUMG00000014761

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1411G>C; p.E471Q; 6:44251833-44251833	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.1984G>A; p.A662T; 6:44253297-44253297	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1984G>A; p.A662T; 6:44253297-44253297	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1645G>A; p.E549K; 6:44252181-44252181	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.774G>T; p.E258D; 6:44250416-44250416	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.823A>G; p.K275E; 6:44250465-44250465	skin	malignant_melanoma	Substitution - Missense
c.1994C>G; p.S665C; 6:44253307-44253307	breast	carcinoma	Substitution - Missense
c.1343G>T; p.R448L; 6:44251765-44251765	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.231C>T; p.P77P; 6:44249460-44249460	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.706G>A; p.E236K; 6:44250348-44250348	urinary_tract; bladder	carcinoma	Substitution - Missense
c.21T>C; p.H7H; 6:44248650-44248650	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2035C>T; p.R679C; 6:44253348-44253348	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1558T>C; p.Y520H; 6:44252094-44252094	liver	carcinoma	Substitution - Missense
c.556A>G; p.K186E; 6:44250062-44250062	skin	malignant_melanoma	Substitution - Missense
c.276C>T; p.G92G; 6:44249505-44249505	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1478A>C; p.Q493P; 6:44252014-44252014	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1703_1705delAAG; p.E569delE; 6:44252239-44252241	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Deletion - In frame
c.2156G>A; p.R719H; 6:44253579-44253579	thyroid	other; neoplasm	Substitution - Missense
c.189G>A; p.S63S; 6:44249418-44249418	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2156G>A; p.R719H; 6:44253579-44253579	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2156G>A; p.R719H; 6:44253579-44253579	thyroid	other; neoplasm	Substitution - Missense
c.2156G>A; p.R719H; 6:44253579-44253579	skin; extremity	malignant_melanoma	Substitution - Missense
c.1286_1290delTCTAT; p.F429fs*1; 6:44251580-44251584	prostate	carcinoma	Deletion - Frameshift
c.275G>A; p.G92D; 6:44249504-44249504	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.354+1G>T; p.?; 6:44249584-44249584	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.2105C>A; p.A702D; 6:44253528-44253528	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.354+1G>T; p.?; 6:44249584-44249584	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Unknown
c.37G>C; p.E13Q; 6:44248666-44248666	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.585G>C; p.E195D; 6:44250091-44250091	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.589C>T; p.R197W; 6:44250095-44250095	skin	malignant_melanoma	Substitution - Missense
c.301A>T; p.N101Y; 6:44249530-44249530	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.122G>T; p.R41L; 6:44248751-44248751	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1370A>G; p.Y457C; 6:44251792-44251792	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.822G>T; p.E274D; 6:44250464-44250464	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.438C>T; p.I146I; 6:44249758-44249758	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1380C>A; p.S460S; 6:44251802-44251802	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1198A>G; p.I400V; 6:44251492-44251492	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1198A>G; p.I400V; 6:44251492-44251492	liver	carcinoma	Substitution - Missense
c.1756T>C; p.S586P; 6:44253069-44253069	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1867delA; p.K624fs*60; 6:44253180-44253180	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.511C>T; p.H171Y; 6:44249831-44249831	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1100A>G; p.D367G; 6:44251190-44251190	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1124A>G; p.N375S; 6:44251418-44251418	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.375G>A; p.M125I; 6:44249695-44249695	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2139C>T; p.G713G; 6:44253562-44253562	thyroid	other; neoplasm	Substitution - coding silent
c.2139C>T; p.G713G; 6:44253562-44253562	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2139C>T; p.G713G; 6:44253562-44253562	thyroid	other; neoplasm	Substitution - coding silent
c.2139C>T; p.G713G; 6:44253562-44253562	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2139C>T; p.G713G; 6:44253562-44253562	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2139C>T; p.G713G; 6:44253562-44253562	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.2139C>T; p.G713G; 6:44253562-44253562	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.560A>C; p.E187A; 6:44250066-44250066	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.504T>A; p.R168R; 6:44249824-44249824	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1555G>A; p.E519K; 6:44252091-44252091	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1327G>A; p.E443K; 6:44251749-44251749	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.933C>T; p.D311D; 6:44250575-44250575	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1327G>A; p.E443K; 6:44251749-44251749	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1989G>C; p.L663L; 6:44253302-44253302	bone; femur	chondrosarcoma	Substitution - coding silent
c.589_590insG; p.V198fs*29; 6:44250095-44250096	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Insertion - Frameshift
c.1810C>T; p.R604W; 6:44253123-44253123	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.784G>A; p.G262S; 6:44250426-44250426	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1214G>A; p.R405H; 6:44251508-44251508	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1400C>T; p.T467I; 6:44251822-44251822	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2052C>G; p.I684M; 6:44253365-44253365	urinary_tract; bladder	carcinoma	Substitution - Missense
c.306G>T; p.L102F; 6:44249535-44249535	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.870C>A; p.T290T; 6:44250512-44250512	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.595_598delAAAG; p.E200fs*1; 6:44250101-44250104	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.705T>G; p.G235G; 6:44250347-44250347	breast	carcinoma	Substitution - coding silent
c.2133C>T; p.L711L; 6:44253556-44253556	thyroid	other; neoplasm	Substitution - coding silent
c.2133C>T; p.L711L; 6:44253556-44253556	breast	carcinoma	Substitution - coding silent
c.1071_1072CC>TT; p.V357>?; 6:44251161-44251162	NS	malignant_melanoma	Complex
c.2133C>T; p.L711L; 6:44253556-44253556	thyroid	other; neoplasm	Substitution - coding silent
c.2133C>T; p.L711L; 6:44253556-44253556	thyroid	other; neoplasm	Substitution - coding silent
c.2133C>T; p.L711L; 6:44253556-44253556	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.2133C>T; p.L711L; 6:44253556-44253556	prostate	carcinoma	Substitution - coding silent
c.504T>C; p.R168R; 6:44249824-44249824	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1071C>T; p.V357V; 6:44251161-44251161	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.1012C>T; p.R338W; 6:44251102-44251102	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1835G>A; p.R612Q; 6:44253148-44253148	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.167A>G; p.Y56C; 6:44249396-44249396	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1368C>T; p.R456R; 6:44251790-44251790	breast	carcinoma	Substitution - coding silent
c.1864G>A; p.A622T; 6:44253177-44253177	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.795G>T; p.K265N; 6:44250437-44250437	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1395G>A; p.E465E; 6:44251817-44251817	breast	carcinoma	Substitution - coding silent
c.490T>G; p.S164A; 6:44249810-44249810	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1811G>A; p.R604Q; 6:44253124-44253124	liver	carcinoma	Substitution - Missense
c.1910C>T; p.T637M; 6:44253223-44253223	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.877C>G; p.P293A; 6:44250519-44250519	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.328A>G; p.T110A; 6:44249557-44249557	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.52C>T; p.Q18*; 6:44248681-44248681	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1560C>T; p.Y520Y; 6:44252096-44252096	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.52C>T; p.Q18*; 6:44248681-44248681	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1415A>G; p.Y472C; 6:44251837-44251837	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1170C>G; p.I390M; 6:44251464-44251464	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1024G>C; p.D342H; 6:44251114-44251114	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2069_2070insT; p.D691fs*1; 6:44253492-44253493	stomach	carcinoma; diffuse_adenocarcinoma	Insertion - Frameshift
c.1174C>T; p.R392*; 6:44251468-44251468	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1804A>G; p.M602V; 6:44253117-44253117	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.154G>A; p.D52N; 6:44249383-44249383	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1575C>T; p.L525L; 6:44252111-44252111	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1010G>A; p.R337H; 6:44251100-44251100	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1073G>A; p.R358H; 6:44251163-44251163	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1604C>G; p.S535*; 6:44252140-44252140	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1604C>G; p.S535*; 6:44252140-44252140	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.90T>C; p.N30N; 6:44248719-44248719	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2164G>T; p.E722*; 6:44253587-44253587	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.132C>G; p.I44M; 6:44248761-44248761	urinary_tract; bladder	carcinoma	Substitution - Missense
c.216A>C; p.K72N; 6:44249445-44249445	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1418T>C; p.V473A; 6:44251840-44251840	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1525G>A; p.E509K; 6:44252061-44252061	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2150C>T; p.A717V; 6:44253573-44253573	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.577C>A; p.L193I; 6:44250083-44250083	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1343G>A; p.R448H; 6:44251765-44251765	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2170G>A; p.D724N; 6:44253593-44253593	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2026C>T; p.H676Y; 6:44253339-44253339	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1532T>C; p.V511A; 6:44252068-44252068	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1097G>A; p.C366Y; 6:44251187-44251187	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1097G>A; p.C366Y; 6:44251187-44251187	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1377C>A; p.T459T; 6:44251799-44251799	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.546C>A; p.I182I; 6:44250052-44250052	skin	malignant_melanoma	Substitution - coding silent
c.1414T>C; p.Y472H; 6:44251836-44251836	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1646_1648delAGA; p.K552delK; 6:44252182-44252184	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.1646_1648delAGA; p.K552delK; 6:44252182-44252184	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - In frame
c.1646_1648delAGA; p.K552delK; 6:44252182-44252184	breast	carcinoma	Deletion - In frame
c.1947G>A; p.K649K; 6:44253260-44253260	breast	carcinoma	Substitution - coding silent
c.1537A>G; p.M513V; 6:44252073-44252073	liver	carcinoma	Substitution - Missense
c.907G>A; p.E303K; 6:44250549-44250549	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.615_616delTT; p.Q207fs*19; 6:44250121-44250122	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1148C>G; p.S383C; 6:44251442-44251442	prostate	carcinoma	Substitution - Missense
c.767A>T; p.D256V; 6:44250409-44250409	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1714G>A; p.D572N; 6:44252250-44252250	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1281G>T; p.K427N; 6:44251575-44251575	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.177G>C; p.L59L; 6:44249406-44249406	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.897G>T; p.E299D; 6:44250539-44250539	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1957G>A; p.D653N; 6:44253270-44253270	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.694G>A; p.E232K; 6:44250336-44250336	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1319G>A; p.G440E; 6:44251741-44251741	haematopoietic_and_lymphoid_tissue; abdomen	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.598G>T; p.E200*; 6:44250104-44250104	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.334G>T; p.A112S; 6:44249563-44249563	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1252G>C; p.E418Q; 6:44251546-44251546	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.867G>T; p.W289C; 6:44250509-44250509	kidney	other; neoplasm	Substitution - Missense
c.867G>T; p.W289C; 6:44250509-44250509	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.666G>A; p.E222E; 6:44250308-44250308	breast	carcinoma	Substitution - coding silent
c.2015A>G; p.D672G; 6:44253328-44253328	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.370T>C; p.S124P; 6:44249690-44249690	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.682G>A; p.D228N; 6:44250324-44250324	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.547C>A; p.L183I; 6:44250053-44250053	skin	malignant_melanoma	Substitution - Missense
c.370T>C; p.S124P; 6:44249690-44249690	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1728G>A; p.E576E; 6:44252264-44252264	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2072A>G; p.D691G; 6:44253495-44253495	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1367G>T; p.R456L; 6:44251789-44251789	breast	carcinoma	Substitution - Missense
c.853A>T; p.T285S; 6:44250495-44250495	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.111G>A; p.E37E; 6:44248740-44248740	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation