lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3306
Symbol	HSPA2
Synonymous	HSP70-2\|HSP70-3
Full name	heat shock 70kDa protein 2
Gene description	heat shock 70kD protein 2\|heat shock-related 70 kDa protein 2
Cytoband	14q24.1
Gene type	protein-coding
Synonymous	MIM:140560; HGNC:HGNC:5235; Ensembl:ENSG00000126803; HPRD:07174

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.162C>T; p.D54D; 14:64541011-64541011	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1852C>A; p.P618T; 14:64542701-64542701	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.162C>T; p.D54D; 14:64541011-64541011	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1864A>G; p.S622G; 14:64542713-64542713	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1864A>G; p.S622G; 14:64542713-64542713	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1864A>G; p.S622G; 14:64542713-64542713	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1405C>T; p.P469S; 14:64542254-64542254	skin	malignant_melanoma	Substitution - Missense
c.159C>T; p.G53G; 14:64541008-64541008	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.739G>C; p.E247Q; 14:64541588-64541588	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.780G>A; p.K260K; 14:64541629-64541629	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.82delG; p.E28fs*35; 14:64540931-64540931	lung	carcinoma; non_small_cell_carcinoma	Deletion - Frameshift
c.393C>T; p.I131I; 14:64541242-64541242	pancreas	carcinoma	Substitution - coding silent
c.393C>T; p.I131I; 14:64541242-64541242	pancreas	carcinoma	Substitution - coding silent
c.1344C>T; p.G448G; 14:64542193-64542193	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.931G>A; p.D311N; 14:64541780-64541780	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.873C>T; p.Y291Y; 14:64541722-64541722	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.873C>T; p.Y291Y; 14:64541722-64541722	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1793A>T; p.K598M; 14:64542642-64542642	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.600C>T; p.I200I; 14:64541449-64541449	skin	malignant_melanoma	Substitution - coding silent
c.1126G>A; p.A376T; 14:64541975-64541975	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.733G>A; p.A245T; 14:64541582-64541582	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1476C>T; p.T492T; 14:64542325-64542325	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1476C>T; p.T492T; 14:64542325-64542325	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1564G>T; p.V522L; 14:64542413-64542413	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.957G>A; p.P319P; 14:64541806-64541806	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.910C>T; p.R304C; 14:64541759-64541759	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.957G>A; p.P319P; 14:64541806-64541806	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.836C>T; p.S279L; 14:64541685-64541685	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1329G>A; p.V443V; 14:64542178-64542178	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.836C>T; p.S279L; 14:64541685-64541685	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.482A>G; p.D161G; 14:64541331-64541331	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1177G>T; p.D393Y; 14:64542026-64542026	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.805G>A; p.A269T; 14:64541654-64541654	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1293C>T; p.F431F; 14:64542142-64542142	skin	malignant_melanoma	Substitution - coding silent
c.943G>A; p.G315R; 14:64541792-64541792	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1619C>T; p.A540V; 14:64542468-64542468	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.378G>T; p.T126T; 14:64541227-64541227	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.975C>T; p.R325R; 14:64541824-64541824	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.975C>T; p.R325R; 14:64541824-64541824	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.915C>T; p.F305F; 14:64541764-64541764	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.861C>T; p.I287I; 14:64541710-64541710	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1699G>A; p.E567K; 14:64542548-64542548	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1457A>C; p.N486T; 14:64542306-64542306	skin	malignant_melanoma	Substitution - Missense
c.483C>T; p.D161D; 14:64541332-64541332	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.57C>T; p.V19V; 14:64540906-64540906	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.112A>T; p.T38S; 14:64540961-64540961	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1081G>C; p.E361Q; 14:64541930-64541930	urinary_tract; bladder	carcinoma	Substitution - Missense
c.979G>T; p.A327S; 14:64541828-64541828	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1038C>T; p.I346I; 14:64541887-64541887	skin	malignant_melanoma	Substitution - coding silent
c.1737G>T; p.E579D; 14:64542586-64542586	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.395C>T; p.A132V; 14:64541244-64541244	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.539C>T; p.A180V; 14:64541388-64541388	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.606C>A; p.D202E; 14:64541455-64541455	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1362G>T; p.K454N; 14:64542211-64542211	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1798A>G; p.K600E; 14:64542647-64542647	skin	malignant_melanoma	Substitution - Missense
c.1656C>T; p.I552I; 14:64542505-64542505	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1841A>G; p.Y614C; 14:64542690-64542690	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.625G>A; p.D209N; 14:64541474-64541474	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1219G>A; p.E407K; 14:64542068-64542068	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.428C>T; p.A143V; 14:64541277-64541277	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1791C>T; p.H597H; 14:64542640-64542640	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.63C>T; p.V21V; 14:64540912-64540912	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1641C>T; p.S547S; 14:64542490-64542490	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - coding silent
c.1192G>A; p.D398N; 14:64542041-64542041	breast	carcinoma	Substitution - Missense
c.1192G>A; p.D398N; 14:64542041-64542041	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1124G>A; p.G375D; 14:64541973-64541973	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1124G>A; p.G375D; 14:64541973-64541973	large_intestine; colon	carcinoma	Substitution - Missense
c.302A>G; p.K101R; 14:64541151-64541151	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.866C>T; p.S289L; 14:64541715-64541715	skin	malignant_melanoma	Substitution - Missense
c.748C>T; p.R250C; 14:64541597-64541597	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.408delG; p.G138fs*8; 14:64541257-64541257	large_intestine; colon	NS	Deletion - Frameshift
c.408delG; p.G138fs*8; 14:64541257-64541257	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1129G>A; p.A377T; 14:64541978-64541978	large_intestine; colon	carcinoma	Substitution - Missense
c.945G>C; p.G315G; 14:64541794-64541794	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.1129G>A; p.A377T; 14:64541978-64541978	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1444G>A; p.D482N; 14:64542293-64542293	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1431C>G; p.I477M; 14:64542280-64542280	ovary	other; neoplasm	Substitution - Missense
c.1431C>G; p.I477M; 14:64542280-64542280	ovary	other; neoplasm	Substitution - Missense
c.814C>T; p.R272C; 14:64541663-64541663	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.506A>G; p.N169S; 14:64541355-64541355	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.506A>G; p.N169S; 14:64541355-64541355	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1526A>G; p.D509G; 14:64542375-64542375	liver	carcinoma	Substitution - Missense
c.708C>T; p.F236F; 14:64541557-64541557	skin	malignant_melanoma	Substitution - coding silent
c.91G>A; p.A31T; 14:64540940-64540940	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1665G>T; p.T555T; 14:64542514-64542514	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.558G>A; p.L186L; 14:64541407-64541407	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.685A>G; p.T229A; 14:64541534-64541534	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.685A>G; p.T229A; 14:64541534-64541534	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.533C>A; p.T178K; 14:64541382-64541382	thyroid	carcinoma	Substitution - Missense
c.237C>T; p.F79F; 14:64541086-64541086	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1893G>A; p.G631G; 14:64542742-64542742	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.547G>T; p.A183S; 14:64541396-64541396	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.585G>A; p.E195E; 14:64541434-64541434	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1270C>A; p.P424T; 14:64542119-64542119	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1722_1724delCGA; p.D575delD; 14:64542571-64542573	large_intestine; rectum	carcinoma; adenocarcinoma	Deletion - In frame
c.575C>T; p.A192V; 14:64541424-64541424	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.575C>T; p.A192V; 14:64541424-64541424	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1618G>A; p.A540T; 14:64542467-64542467	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1624delA; p.N543fs*19; 14:64542473-64542473	oesophagus; lower_third	carcinoma; adenocarcinoma	Deletion - Frameshift
c.276G>A; p.P92P; 14:64541125-64541125	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.511C>T; p.L171L; 14:64541360-64541360	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1859G>A; p.G620D; 14:64542708-64542708	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1022G>T; p.G341V; 14:64541871-64541871	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1723G>A; p.D575N; 14:64542572-64542572	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.287T>C; p.V96A; 14:64541136-64541136	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.823C>G; p.R275G; 14:64541672-64541672	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.497C>T; p.T166M; 14:64541346-64541346	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.515G>A; p.R172H; 14:64541364-64541364	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.936C>T; p.L312L; 14:64541785-64541785	skin	malignant_melanoma	Substitution - coding silent
c.535G>T; p.A179S; 14:64541384-64541384	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1162T>C; p.S388P; 14:64542011-64542011	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.10C>T; p.R4C; 14:64540859-64540859	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.58G>T; p.G20W; 14:64540907-64540907	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.58G>T; p.G20W; 14:64540907-64540907	breast	carcinoma	Substitution - Missense
c.1194C>T; p.D398D; 14:64542043-64542043	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.24C>T; p.I8I; 14:64540873-64540873	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1871G>A; p.G624D; 14:64542720-64542720	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.130G>C; p.A44P; 14:64540979-64540979	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1871G>A; p.G624D; 14:64542720-64542720	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.429G>A; p.A143A; 14:64541278-64541278	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.1339G>A; p.E447K; 14:64542188-64542188	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.166G>A; p.A56T; 14:64541015-64541015	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.930C>T; p.A310A; 14:64541779-64541779	skin	malignant_melanoma	Substitution - coding silent
c.1405C>G; p.P469A; 14:64542254-64542254	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1537C>G; p.L513V; 14:64542386-64542386	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1125C>T; p.G375G; 14:64541974-64541974	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.438G>A; p.T146T; 14:64541287-64541287	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.1698C>T; p.S566S; 14:64542547-64542547	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1156G>A; p.D386N; 14:64542005-64542005	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.735G>A; p.A245A; 14:64541584-64541584	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1689C>T; p.G563G; 14:64542538-64542538	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.96C>T; p.N32N; 14:64540945-64540945	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1460G>C; p.G487A; 14:64542309-64542309	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1167G>T; p.E389D; 14:64542016-64542016	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1167G>T; p.E389D; 14:64542016-64542016	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.683A>T; p.D228V; 14:64541532-64541532	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1098C>G; p.I366M; 14:64541947-64541947	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.53G>A; p.C18Y; 14:64540902-64540902	breast	carcinoma	Substitution - Missense
c.1098C>G; p.I366M; 14:64541947-64541947	urinary_tract; bladder	carcinoma	Substitution - Missense
c.498G>A; p.T166T; 14:64541347-64541347	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1423C>T; p.P475S; 14:64542272-64542272	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1195G>A; p.V399M; 14:64542044-64542044	large_intestine; colon	carcinoma	Substitution - Missense
c.1423C>T; p.P475S; 14:64542272-64542272	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.163G>A; p.A55T; 14:64541012-64541012	central_nervous_system; brain	glioma	Substitution - Missense
c.163G>A; p.A55T; 14:64541012-64541012	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1195G>A; p.V399M; 14:64542044-64542044	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.811G>A; p.E271K; 14:64541660-64541660	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1338C>T; p.Y446Y; 14:64542187-64542187	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.703G>A; p.D235N; 14:64541552-64541552	liver	carcinoma	Substitution - Missense
c.703G>A; p.D235N; 14:64541552-64541552	liver	carcinoma	Substitution - Missense
c.1410G>A; p.A470A; 14:64542259-64542259	prostate	carcinoma	Substitution - coding silent
c.516C>T; p.R172R; 14:64541365-64541365	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1218C>T; p.I406I; 14:64542067-64542067	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1061A>T; p.Q354L; 14:64541910-64541910	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1203G>A; p.P401P; 14:64542052-64542052	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1203G>A; p.P401P; 14:64542052-64542052	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.903G>A; p.T301T; 14:64541752-64541752	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.909C>G; p.A303A; 14:64541758-64541758	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1284G>A; p.T428T; 14:64542133-64542133	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.726C>T; p.S242S; 14:64541575-64541575	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.194C>T; p.T65I; 14:64541043-64541043	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.784G>A; p.A262T; 14:64541633-64541633	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation