lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3202
Symbol	HOXA5
Synonymous	HOX1\|HOX1.3\|HOX1C
Full name	homeobox A5
Gene description	homeo box 1C\|homeo box A5\|homeobox protein HOXA5\|homeobox protein Hox-1C\|homeobox protein Hox-A5
Cytoband	7p15.2
Gene type	protein-coding
Synonymous	MIM:142952; HGNC:HGNC:5106; Ensembl:ENSG00000106004; HPRD:00840; Vega:OTTHUMG00000023214

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.492C>A; p.S164R; 7:27143116-27143116	breast	carcinoma	Substitution - Missense
c.448G>A; p.E150K; 7:27143160-27143160	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.179G>A; p.G60D; 7:27143429-27143429	skin	malignant_melanoma	Substitution - Missense
c.322C>T; p.P108S; 7:27143286-27143286	skin	malignant_melanoma	Substitution - Missense
c.756delA; p.D253fs*4; 7:27141892-27141892	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.40C>T; p.P14S; 7:27143568-27143568	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.300G>T; p.P100P; 7:27143308-27143308	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.665G>A; p.R222H; 7:27141983-27141983	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.312C>T; p.S104S; 7:27143296-27143296	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.194G>T; p.G65V; 7:27143414-27143414	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.480G>A; p.A160A; 7:27143128-27143128	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.443G>C; p.G148A; 7:27143165-27143165	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.97C>T; p.Q33*; 7:27143511-27143511	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.34C>A; p.R12S; 7:27143574-27143574	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.86C>T; p.S29F; 7:27143522-27143522	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.406C>G; p.H136D; 7:27143202-27143202	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.29delG; p.C10fs*21; 7:27143579-27143579	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.29delG; p.C10fs*21; 7:27143579-27143579	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.29delG; p.C10fs*21; 7:27143579-27143579	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.29delG; p.C10fs*21; 7:27143579-27143579	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.757G>T; p.D253Y; 7:27141891-27141891	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.714A>G; p.Q238Q; 7:27141934-27141934	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.716T>C; p.I239T; 7:27141932-27141932	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.31G>T; p.G11C; 7:27143577-27143577	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.323C>A; p.P108H; 7:27143285-27143285	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.733A>C; p.N245H; 7:27141915-27141915	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.351C>T; p.G117G; 7:27143257-27143257	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.584G>T; p.G195V; 7:27142064-27142064	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.682A>G; p.I228V; 7:27141966-27141966	breast	carcinoma	Substitution - Missense
c.610C>T; p.R204C; 7:27142038-27142038	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.262C>T; p.Q88*; 7:27143346-27143346	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.485C>G; p.A162G; 7:27143123-27143123	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.199G>A; p.G67R; 7:27143409-27143409	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.349G>T; p.G117C; 7:27143259-27143259	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.800C>A; p.A267D; 7:27141848-27141848	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.97C>A; p.Q33K; 7:27143511-27143511	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.394G>A; p.A132T; 7:27143214-27143214	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.460C>A; p.P154T; 7:27143148-27143148	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.583G>A; p.G195S; 7:27142065-27142065	skin	malignant_melanoma	Substitution - Missense
c.160C>T; p.L54F; 7:27143448-27143448	ovary	carcinoma	Substitution - Missense
c.490A>T; p.S164C; 7:27143118-27143118	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.357A>T; p.K119N; 7:27143251-27143251	skin	malignant_melanoma	Substitution - Missense
c.311C>T; p.S104F; 7:27143297-27143297	breast	carcinoma	Substitution - Missense
c.624G>A; p.L208L; 7:27142024-27142024	skin	malignant_melanoma	Substitution - coding silent
c.595C>T; p.R199W; 7:27142053-27142053	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.595C>T; p.R199W; 7:27142053-27142053	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.694C>G; p.L232V; 7:27141954-27141954	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.694C>G; p.L232V; 7:27141954-27141954	central_nervous_system; brain	glioma	Substitution - Missense
c.240G>A; p.A80A; 7:27143368-27143368	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.787G>T; p.A263S; 7:27141861-27141861	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.125_126CC>AA; p.S42*; 7:27143482-27143483	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.177G>T; p.S59S; 7:27143431-27143431	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.404C>G; p.T135S; 7:27143204-27143204	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.425G>A; p.G142E; 7:27143183-27143183	skin	malignant_melanoma	Substitution - Missense
c.120G>A; p.M40I; 7:27143488-27143488	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.679G>A; p.E227K; 7:27141969-27141969	skin; trunk	malignant_melanoma	Substitution - Missense
c.786C>T; p.A262A; 7:27141862-27141862	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.805C>T; p.R269C; 7:27141843-27141843	skin	malignant_melanoma	Substitution - Missense
c.458C>A; p.A153D; 7:27143150-27143150	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.610C>A; p.R204S; 7:27142038-27142038	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.805C>T; p.R269C; 7:27141843-27141843	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.652C>T; p.R218C; 7:27141996-27141996	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.634_636delAAG; p.K212delK; 7:27142012-27142014	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.784G>T; p.A262S; 7:27141864-27141864	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.542G>A; p.R181H; 7:27143066-27143066	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.126C>A; p.S42S; 7:27143482-27143482	liver	carcinoma	Substitution - coding silent
c.542G>A; p.R181H; 7:27143066-27143066	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.126C>A; p.S42S; 7:27143482-27143482	liver	carcinoma	Substitution - coding silent
c.516C>A; p.A172A; 7:27143092-27143092	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation