lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3135
Symbol	HLA-G
Synonymous	MHC-G
Full name	major histocompatibility complex, class I, G
Gene description	HLA G antigen\|HLA class I histocompatibility antigen, alpha chain G\|HLA class I molecule\|HLA-G histocompatibility antigen, class I, G\|MHC class I antigen G\|b2 microglobulin
Cytoband	6p21.3
Gene type	protein-coding
Synonymous	MIM:142871; HGNC:HGNC:4964; Ensembl:ENSG00000204632; HPRD:00834; Vega:OTTHUMG00000031157

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.201G>A; p.P67P; 6:29828174-29828174	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.831G>A; p.E277E; 6:29829629-29829629	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.933C>T; p.I311I; 6:29829853-29829853	skin	malignant_melanoma	Substitution - coding silent
c.933C>T; p.I311I; 6:29829853-29829853	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.902C>A; p.S301Y; 6:29829822-29829822	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.20G>A; p.R7Q; 6:29827864-29827864	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.906C>T; p.S302S; 6:29829826-29829826	skin	malignant_melanoma	Substitution - coding silent
c.351C>T; p.H117H; 6:29828550-29828550	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.351C>T; p.H117H; 6:29828550-29828550	thyroid	other; neoplasm	Substitution - coding silent
c.1002G>A; p.K334K; 6:29829922-29829922	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1012G>T; p.D338Y; 6:29829932-29829932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1012G>T; p.D338Y; 6:29829932-29829932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.871C>T; p.P291S; 6:29829669-29829669	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1012G>T; p.D338Y; 6:29829932-29829932	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1012+1G>T; p.?; 6:29829933-29829933	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.674T>A; p.L225Q; 6:29829472-29829472	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.258G>T; p.E86D; 6:29828231-29828231	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.601G>A; p.E201K; 6:29828800-29828800	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.405C>T; p.R135R; 6:29828604-29828604	breast	carcinoma	Substitution - coding silent
c.763G>T; p.V255L; 6:29829561-29829561	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.763G>T; p.V255L; 6:29829561-29829561	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.925A>G; p.M309V; 6:29829845-29829845	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.925A>G; p.M309V; 6:29829845-29829845	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.925A>G; p.M309V; 6:29829845-29829845	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.925A>G; p.M309V; 6:29829845-29829845	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.925A>G; p.M309V; 6:29829845-29829845	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.925A>G; p.M309V; 6:29829845-29829845	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.925A>G; p.M309V; 6:29829845-29829845	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.925A>G; p.M309V; 6:29829845-29829845	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.540G>A; p.R180R; 6:29828739-29828739	skin	malignant_melanoma	Substitution - coding silent
c.617C>G; p.A206G; 6:29828816-29828816	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.159C>T; p.D53D; 6:29828132-29828132	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.949G>C; p.V317L; 6:29829869-29829869	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.791C>T; p.T264I; 6:29829589-29829589	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.791C>T; p.T264I; 6:29829589-29829589	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.203G>A; p.R68K; 6:29828176-29828176	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.621C>T; p.D207D; 6:29829419-29829419	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.956C>G; p.A319G; 6:29829876-29829876	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.956C>G; p.A319G; 6:29829876-29829876	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.956C>G; p.A319G; 6:29829876-29829876	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.956C>G; p.A319G; 6:29829876-29829876	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.956C>G; p.A319G; 6:29829876-29829876	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.744G>T; p.Q248H; 6:29829542-29829542	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.956C>G; p.A319G; 6:29829876-29829876	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.956C>G; p.A319G; 6:29829876-29829876	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.956C>G; p.A319G; 6:29829876-29829876	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.47C>T; p.A16V; 6:29827891-29827891	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.65C>G; p.T22S; 6:29827909-29827909	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.786T>C; p.D262D; 6:29829584-29829584	prostate	carcinoma	Substitution - coding silent
c.479C>T; p.A160V; 6:29828678-29828678	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.400C>A; p.L134I; 6:29828599-29828599	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.400C>A; p.L134I; 6:29828599-29828599	thyroid	other; neoplasm	Substitution - Missense
c.400C>A; p.L134I; 6:29828599-29828599	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.430G>A; p.G144S; 6:29828629-29828629	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.905C>T; p.S302F; 6:29829825-29829825	skin	malignant_melanoma	Substitution - Missense
c.905C>T; p.S302F; 6:29829825-29829825	skin	malignant_melanoma	Substitution - Missense
c.861T>C; p.H287H; 6:29829659-29829659	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.704C>T; p.A235V; 6:29829502-29829502	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.899A>C; p.Q300P; 6:29829819-29829819	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.873G>A; p.P291P; 6:29829671-29829671	thyroid	other; neoplasm	Substitution - coding silent
c.498C>T; p.I166I; 6:29828697-29828697	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.475G>A; p.A159T; 6:29828674-29828674	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.898C>A; p.Q300K; 6:29829818-29829818	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.475G>A; p.A159T; 6:29828674-29828674	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.475G>A; p.A159T; 6:29828674-29828674	prostate	carcinoma	Substitution - Missense
c.15G>A; p.A5A; 6:29827859-29827859	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.938C>A; p.A313D; 6:29829858-29829858	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.678G>T; p.R226S; 6:29829476-29829476	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.339G>A; p.E113E; 6:29828312-29828312	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.75C>G; p.G25G; 6:29828048-29828048	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.999A>G; p.R333R; 6:29829919-29829919	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.942C>T; p.G314G; 6:29829862-29829862	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.75C>G; p.G25G; 6:29828048-29828048	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.36G>A; p.L12L; 6:29827880-29827880	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.36G>A; p.L12L; 6:29827880-29827880	thyroid	other; neoplasm	Substitution - coding silent
c.977C>T; p.A326V; 6:29829897-29829897	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.734G>A; p.G245E; 6:29829532-29829532	skin	malignant_melanoma	Substitution - Missense
c.977C>T; p.A326V; 6:29829897-29829897	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.977C>T; p.A326V; 6:29829897-29829897	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.977C>T; p.A326V; 6:29829897-29829897	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.977C>T; p.A326V; 6:29829897-29829897	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.282C>T; p.H94H; 6:29828255-29828255	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.977C>T; p.A326V; 6:29829897-29829897	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.977C>T; p.A326V; 6:29829897-29829897	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.977C>T; p.A326V; 6:29829897-29829897	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.636C>A; p.H212Q; 6:29829434-29829434	urinary_tract; bladder	carcinoma	Substitution - Missense
c.461T>C; p.L154P; 6:29828660-29828660	skin	malignant_melanoma	Substitution - Missense
c.980T>C; p.V327A; 6:29829900-29829900	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1015T>A; p.*339R; 6:29830380-29830380	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Nonstop extension
c.1015T>A; p.*339R; 6:29830380-29830380	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Nonstop extension
c.1015T>A; p.*339R; 6:29830380-29830380	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Nonstop extension
c.1015T>A; p.*339R; 6:29830380-29830380	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Nonstop extension
c.1015T>A; p.*339R; 6:29830380-29830380	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Nonstop extension
c.1015T>A; p.*339R; 6:29830380-29830380	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Nonstop extension
c.1015T>A; p.*339R; 6:29830380-29830380	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Nonstop extension
c.680G>C; p.C227S; 6:29829478-29829478	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.981C>T; p.V327V; 6:29829901-29829901	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.636C>T; p.H212H; 6:29829434-29829434	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.981C>T; p.V327V; 6:29829901-29829901	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.981C>T; p.V327V; 6:29829901-29829901	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.392G>A; p.G131E; 6:29828591-29828591	skin	malignant_melanoma	Substitution - Missense
c.991C>A; p.L331M; 6:29829911-29829911	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.991C>A; p.L331M; 6:29829911-29829911	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.886C>T; p.L296L; 6:29829684-29829684	skin	malignant_melanoma	Substitution - coding silent
c.239G>T; p.G80V; 6:29828212-29828212	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.765G>C; p.V255V; 6:29829563-29829563	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.765G>C; p.V255V; 6:29829563-29829563	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.52A>C; p.T18P; 6:29827896-29827896	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.908T>A; p.L303Q; 6:29829828-29829828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.908T>A; p.L303Q; 6:29829828-29829828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.908T>A; p.L303Q; 6:29829828-29829828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.168G>T; p.Q56H; 6:29828141-29828141	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.157G>T; p.D53Y; 6:29828130-29828130	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.648C>A; p.H216Q; 6:29829446-29829446	breast	carcinoma	Substitution - Missense
c.544G>A; p.A182T; 6:29828743-29828743	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.243G>A; p.P81P; 6:29828216-29828216	thyroid	other; neoplasm	Substitution - coding silent
c.615C>T; p.R205R; 6:29828814-29828814	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.615C>T; p.R205R; 6:29828814-29828814	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.519G>A; p.A173A; 6:29828718-29828718	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.910C>T; p.P304S; 6:29829830-29829830	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.620_621insC; p.K210fs*11; 6:29829418-29829419	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.145A>G; p.M49V; 6:29828118-29828118	prostate	carcinoma	Substitution - Missense
c.165G>A; p.T55T; 6:29828138-29828138	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.176G>A; p.R59Q; 6:29828149-29828149	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.354C>T; p.T118T; 6:29828553-29828553	skin	malignant_melanoma	Substitution - coding silent
c.978G>T; p.A326A; 6:29829898-29829898	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.459delC; p.L154fs*60; 6:29828658-29828658	breast	carcinoma	Deletion - Frameshift
c.459delC; p.L154fs*60; 6:29828658-29828658	pancreas	carcinoma; adenocarcinoma	Deletion - Frameshift
c.316C>T; p.R106C; 6:29828289-29828289	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.111C>T; p.S37S; 6:29828084-29828084	skin	malignant_melanoma	Substitution - coding silent
c.60C>A; p.T20T; 6:29827904-29827904	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.667G>A; p.A223T; 6:29829465-29829465	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.982G>C; p.A328P; 6:29829902-29829902	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.244G>A; p.E82K; 6:29828217-29828217	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.75C>A; p.G25G; 6:29828048-29828048	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation