lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3122
Symbol	HLA-DRA
Synonymous	HLA-DRA1\|MLRW
Full name	major histocompatibility complex, class II, DR alpha
Gene description	HLA class II histocompatibility antigen, DR alpha chain\|MHC cell surface glycoprotein\|MHC class II antigen DRA\|histocompatibility antigen HLA-DR alpha
Cytoband	6p21.3
Gene type	protein-coding
Synonymous	MIM:142860; HGNC:HGNC:4947; Ensembl:ENSG00000204287; HPRD:00833; Vega:OTTHUMG00000031269

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.511C>T; p.R171C; 6:32443367-32443367	skin	malignant_melanoma	Substitution - Missense
c.511C>T; p.R171C; 6:32443367-32443367	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.302G>A; p.R101H; 6:32442667-32442667	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.443G>C; p.R148P; 6:32443299-32443299	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.629C>T; p.P210L; 6:32443774-32443774	skin	malignant_melanoma	Substitution - Missense
c.505C>T; p.L169F; 6:32443361-32443361	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.595C>T; p.L199F; 6:32443451-32443451	skin	malignant_melanoma	Substitution - Missense
c.448G>A; p.G150R; 6:32443304-32443304	skin	malignant_melanoma	Substitution - Missense
c.709T>G; p.F237V; 6:32443854-32443854	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.83-10T>A; p.?; 6:32442438-32442438	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.449G>A; p.G150E; 6:32443305-32443305	skin	malignant_melanoma	Substitution - Missense
c.708C>G; p.I236M; 6:32443853-32443853	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.197C>T; p.T66M; 6:32442562-32442562	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.82G>A; p.E28K; 6:32440032-32440032	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.337G>A; p.E113K; 6:32443193-32443193	skin; back	malignant_melanoma	Substitution - Missense
c.371T>C; p.L124P; 6:32443227-32443227	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.192G>A; p.K64K; 6:32442557-32442557	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.214G>T; p.E72*; 6:32442579-32442579	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.591G>T; p.E197D; 6:32443447-32443447	skin; ear	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.443G>A; p.R148Q; 6:32443299-32443299	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.301C>T; p.R101C; 6:32442666-32442666	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.443G>A; p.R148Q; 6:32443299-32443299	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.724T>G; p.L242V; 6:32443869-32443869	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.431T>C; p.V144A; 6:32443287-32443287	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.224G>A; p.R75Q; 6:32442589-32442589	skin	malignant_melanoma	Substitution - Missense
c.219T>C; p.F73F; 6:32442584-32442584	skin	malignant_melanoma	Substitution - coding silent
c.448G>C; p.G150R; 6:32443304-32443304	NS	NS	Substitution - Missense
c.728G>A; p.R243H; 6:32443873-32443873	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.728G>A; p.R243H; 6:32443873-32443873	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.655G>A; p.V219M; 6:32443800-32443800	skin; trunk	malignant_melanoma	Substitution - Missense
c.317C>T; p.P106L; 6:32442682-32442682	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.317C>T; p.P106L; 6:32442682-32442682	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.748C>T; p.R250C; 6:32443893-32443893	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.748C>T; p.R250C; 6:32443893-32443893	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.748C>T; p.R250C; 6:32443893-32443893	thyroid	carcinoma	Substitution - Missense
c.293T>C; p.M98T; 6:32442658-32442658	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.294G>A; p.M98I; 6:32442659-32442659	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.646G>T; p.E216*; 6:32443791-32443791	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.46G>C; p.V16L; 6:32439996-32439996	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.629C>A; p.P210H; 6:32443774-32443774	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.600C>G; p.L200L; 6:32443456-32443456	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.749G>A; p.R250H; 6:32443894-32443894	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.442C>T; p.R148*; 6:32443298-32443298	skin	malignant_melanoma	Substitution - Nonsense
c.403G>A; p.D135N; 6:32443259-32443259	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.632T>C; p.L211P; 6:32443777-32443777	skin; trunk	malignant_melanoma	Substitution - Missense
c.337G>C; p.E113Q; 6:32443193-32443193	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.176T>C; p.V59A; 6:32442541-32442541	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.385G>A; p.V129I; 6:32443241-32443241	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.19C>T; p.P7S; 6:32439969-32439969	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.19C>T; p.P7S; 6:32439969-32439969	urinary_tract; bladder	carcinoma	Substitution - Missense
c.620C>T; p.A207V; 6:32443765-32443765	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.524A>G; p.Y175C; 6:32443380-32443380	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.402A>C; p.I134I; 6:32443258-32443258	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.402A>C; p.I134I; 6:32443258-32443258	thyroid	other; neoplasm	Substitution - coding silent
c.607T>C; p.W203R; 6:32443463-32443463	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.332C>T; p.P111L; 6:32443188-32443188	skin	malignant_melanoma	Substitution - Missense
c.520C>T; p.H174Y; 6:32443376-32443376	skin	malignant_melanoma	Substitution - Missense
c.435G>A; p.T145T; 6:32443291-32443291	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.234C>A; p.S78R; 6:32442599-32442599	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.645A>T; p.T215T; 6:32443790-32443790	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.367G>T; p.E123*; 6:32443223-32443223	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.4G>A; p.A2T; 6:32439954-32439954	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.278C>A; p.A93D; 6:32442643-32442643	central_nervous_system; brain	glioma	Substitution - Missense
c.353C>T; p.T118I; 6:32443209-32443209	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.193G>A; p.E65K; 6:32442558-32442558	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.529C>T; p.P177S; 6:32443385-32443385	skin	malignant_melanoma	Substitution - Missense
c.529C>T; p.P177S; 6:32443385-32443385	skin	malignant_melanoma	Substitution - Missense
c.205C>T; p.R69W; 6:32442570-32442570	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.83-10T>C; p.?; 6:32442438-32442438	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation