lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3099
Symbol	HK2
Synonymous	HKII\|HXK2
Full name	hexokinase 2
Gene description	HK II\|hexokinase type II\|hexokinase-2\|hexokinase-2, muscle\|muscle form hexokinase
Cytoband	2p13
Gene type	protein-coding
Synonymous	MIM:601125; HGNC:HGNC:4923; Ensembl:ENSG00000159399; HPRD:03080; Vega:OTTHUMG00000129972

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.2663T>C; p.V888A; 2:74890850-74890850	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.686T>C; p.I229T; 2:74873938-74873938	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.684C>G; p.L228L; 2:74873936-74873936	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2141A>G; p.D714G; 2:74886595-74886595	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.531C>T; p.S177S; 2:74873311-74873311	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.821_822ins59; p.T275fs*32; 2:74874395-74874396	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Insertion - Frameshift
c.2104C>T; p.R702W; 2:74886558-74886558	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.11C>G; p.S4W; 2:74834591-74834591	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1103G>C; p.C368S; 2:74878759-74878759	liver	carcinoma	Substitution - Missense
c.1147G>A; p.A383T; 2:74878803-74878803	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1019C>T; p.S340L; 2:74877309-74877309	breast	carcinoma	Substitution - Missense
c.2735G>T; p.R912L; 2:74890922-74890922	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2285C>T; p.T762I; 2:74887968-74887968	skin	malignant_melanoma	Substitution - Missense
c.1525G>A; p.V509I; 2:74880524-74880524	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1516A>G; p.S506G; 2:74880515-74880515	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.713A>G; p.Y238C; 2:74874287-74874287	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.859A>G; p.N287D; 2:74874433-74874433	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2549G>A; p.G850E; 2:74889418-74889418	skin	malignant_melanoma	Substitution - Missense
c.656A>T; p.Y219F; 2:74873908-74873908	skin	malignant_melanoma	Substitution - Missense
c.2518G>A; p.A840T; 2:74889387-74889387	bone; pelvis	chondrosarcoma	Substitution - Missense
c.968A>G; p.K323R; 2:74877258-74877258	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1878T>G; p.S626S; 2:74885532-74885532	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.76C>A; p.L26I; 2:74854305-74854305	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.712T>C; p.Y238H; 2:74874286-74874286	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.475C>T; p.H159Y; 2:74872399-74872399	breast	carcinoma	Substitution - Missense
c.2537G>A; p.R846Q; 2:74889406-74889406	skin	malignant_melanoma	Substitution - Missense
c.1540A>C; p.T514P; 2:74880539-74880539	breast	carcinoma	Substitution - Missense
c.2076C>T; p.N692N; 2:74886530-74886530	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2207C>A; p.P736H; 2:74886661-74886661	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2076C>T; p.N692N; 2:74886530-74886530	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1863A>G; p.K621K; 2:74885517-74885517	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.16C>T; p.L6L; 2:74834596-74834596	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1215G>A; p.R405R; 2:74878871-74878871	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.16C>T; p.L6L; 2:74834596-74834596	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.933G>T; p.V311V; 2:74877223-74877223	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.2545C>T; p.R849C; 2:74889414-74889414	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.933G>T; p.V311V; 2:74877223-74877223	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1319T>C; p.V440A; 2:74880318-74880318	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2263_2274del12; p.R755_L758delRNIL; 2:74887946-74887957	large_intestine; colon	carcinoma	Deletion - In frame
c.1614C>T; p.F538F; 2:74881754-74881754	breast	carcinoma	Substitution - coding silent
c.1542C>T; p.T514T; 2:74880541-74880541	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1349G>C; p.G450A; 2:74880348-74880348	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2515G>A; p.A839T; 2:74889384-74889384	pancreas	carcinoma	Substitution - Missense
c.727C>T; p.R243C; 2:74874301-74874301	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1758C>G; p.L586L; 2:74882158-74882158	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2072G>A; p.R691H; 2:74886526-74886526	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2740G>T; p.A914S; 2:74890927-74890927	liver	carcinoma	Substitution - Missense
c.2740G>T; p.A914S; 2:74890927-74890927	liver	carcinoma	Substitution - Missense
c.569G>A; p.R190Q; 2:74873349-74873349	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2298A>C; p.L766L; 2:74887981-74887981	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2610-1G>T; p.?; 2:74890796-74890796	endometrium	carcinoma; endometrioid_carcinoma	Unknown
c.1399C>T; p.H467Y; 2:74880398-74880398	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2487G>T; p.R829R; 2:74889356-74889356	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1692G>A; p.Q564Q; 2:74881832-74881832	skin	malignant_melanoma	Substitution - coding silent
c.2447G>A; p.S816N; 2:74889316-74889316	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2651C>T; p.P884L; 2:74890838-74890838	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1343G>T; p.G448V; 2:74880342-74880342	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1331G>A; p.R444H; 2:74880330-74880330	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.728G>T; p.R243L; 2:74874302-74874302	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.464C>T; p.S155L; 2:74872388-74872388	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.65T>A; p.V22D; 2:74854294-74854294	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.749G>C; p.G250A; 2:74874323-74874323	breast	carcinoma	Substitution - Missense
c.1681G>T; p.A561S; 2:74881821-74881821	urinary_tract; bladder	carcinoma	Substitution - Missense
c.220G>T; p.G74W; 2:74854449-74854449	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.470C>T; p.P157L; 2:74872394-74872394	skin	malignant_melanoma	Substitution - Missense
c.2192A>G; p.E731G; 2:74886646-74886646	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.753T>C; p.D251D; 2:74874327-74874327	thyroid	other; neoplasm	Substitution - coding silent
c.2482C>T; p.R828W; 2:74889351-74889351	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1505A>G; p.E502G; 2:74880504-74880504	thyroid	other; neoplasm	Substitution - Missense
c.2729G>A; p.R910H; 2:74890916-74890916	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.806C>T; p.S269L; 2:74874380-74874380	skin	malignant_melanoma	Substitution - Missense
c.2312G>A; p.R771H; 2:74887995-74887995	skin	malignant_melanoma	Substitution - Missense
c.1563C>T; p.D521D; 2:74880562-74880562	central_nervous_system; brain	glioma	Substitution - coding silent
c.1597C>A; p.L533I; 2:74881737-74881737	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2578G>A; p.V860M; 2:74889447-74889447	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1236C>T; p.V412V; 2:74878892-74878892	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1680C>T; p.Y560Y; 2:74881820-74881820	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2473G>A; p.V825M; 2:74889342-74889342	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2208C>G; p.P736P; 2:74886662-74886662	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.105C>T; p.T35T; 2:74854334-74854334	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2325G>A; p.R775R; 2:74888008-74888008	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1864G>T; p.G622C; 2:74885518-74885518	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1864G>T; p.G622C; 2:74885518-74885518	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1864G>T; p.G622C; 2:74885518-74885518	large_intestine; colon	carcinoma	Substitution - Missense
c.1241G>A; p.G414D; 2:74878897-74878897	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1864G>T; p.G622C; 2:74885518-74885518	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.971T>G; p.L324R; 2:74877261-74877261	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.736G>A; p.D246N; 2:74874310-74874310	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.47A>G; p.H16R; 2:74834627-74834627	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.735C>T; p.I245I; 2:74874309-74874309	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1935+1G>T; p.?; 2:74885590-74885590	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Unknown
c.1935+1G>T; p.?; 2:74885590-74885590	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma; medullomyoblastoma	Unknown
c.1489C>A; p.R497R; 2:74880488-74880488	breast	carcinoma	Substitution - coding silent
c.1315G>A; p.D439N; 2:74880314-74880314	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1779C>T; p.G593G; 2:74882179-74882179	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.1779C>T; p.G593G; 2:74882179-74882179	pancreas	carcinoma	Substitution - coding silent
c.343C>T; p.P115S; 2:74867752-74867752	skin	malignant_melanoma	Substitution - Missense
c.343C>T; p.P115S; 2:74867752-74867752	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.413T>C; p.M138T; 2:74872337-74872337	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1717G>A; p.E573K; 2:74881857-74881857	skin; trunk	malignant_melanoma	Substitution - Missense
c.55G>A; p.V19M; 2:74834635-74834635	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2298A>G; p.L766L; 2:74887981-74887981	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2298A>G; p.L766L; 2:74887981-74887981	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.408C>T; p.N136N; 2:74872332-74872332	liver	carcinoma	Substitution - coding silent
c.2298A>G; p.L766L; 2:74887981-74887981	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.359G>A; p.R120Q; 2:74867768-74867768	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1728C>T; p.D576D; 2:74882128-74882128	skin	malignant_melanoma	Substitution - coding silent
c.962G>T; p.G321V; 2:74877252-74877252	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.438G>T; p.K146N; 2:74872362-74872362	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2615C>T; p.A872V; 2:74890802-74890802	breast	carcinoma	Substitution - Missense
c.2261_2272del12; p.R755_L758delRNIL; 2:74887944-74887955	large_intestine	carcinoma; adenocarcinoma	Deletion - In frame
c.2045G>A; p.S682N; 2:74886499-74886499	thyroid	carcinoma	Substitution - Missense
c.1329C>G; p.L443L; 2:74880328-74880328	breast	carcinoma; HER-positive_carcinoma	Substitution - coding silent
c.2251G>T; p.G751C; 2:74887934-74887934	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1176C>T; p.A392A; 2:74878832-74878832	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1504G>A; p.E502K; 2:74880503-74880503	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.941C>T; p.A314V; 2:74877231-74877231	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1978G>A; p.G660R; 2:74886336-74886336	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2743G>A; p.G915R; 2:74890930-74890930	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1599T>G; p.L533L; 2:74881739-74881739	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.88C>T; p.R30C; 2:74854317-74854317	thyroid	carcinoma	Substitution - Missense
c.88C>T; p.R30C; 2:74854317-74854317	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.88C>T; p.R30C; 2:74854317-74854317	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1348G>T; p.G450C; 2:74880347-74880347	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1552G>T; p.A518S; 2:74880551-74880551	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1330C>T; p.R444C; 2:74880329-74880329	skin	malignant_melanoma	Substitution - Missense
c.1087C>T; p.P363S; 2:74878743-74878743	skin	malignant_melanoma	Substitution - Missense
c.1147G>C; p.A383P; 2:74878803-74878803	breast	carcinoma	Substitution - Missense
c.977C>G; p.P326R; 2:74877267-74877267	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.938T>C; p.M313T; 2:74877228-74877228	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1901T>C; p.V634A; 2:74885555-74885555	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1881C>T; p.G627G; 2:74885535-74885535	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1836C>T; p.D612D; 2:74882236-74882236	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1813C>T; p.P605S; 2:74882213-74882213	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.706G>A; p.A236T; 2:74874280-74874280	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2442C>T; p.D814D; 2:74889311-74889311	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.124C>T; p.R42W; 2:74854353-74854353	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.585G>A; p.R195R; 2:74873365-74873365	skin	malignant_melanoma	Substitution - coding silent
c.2051C>T; p.A684V; 2:74886505-74886505	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2343C>T; p.I781I; 2:74888026-74888026	skin	malignant_melanoma	Substitution - coding silent
c.2704G>A; p.A902T; 2:74890891-74890891	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.557T>C; p.V186A; 2:74873337-74873337	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2218A>T; p.R740W; 2:74886672-74886672	liver	carcinoma	Substitution - Missense
c.1785C>T; p.S595S; 2:74882185-74882185	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2581G>T; p.D861Y; 2:74889450-74889450	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1506G>A; p.E502E; 2:74880505-74880505	thyroid	other; neoplasm	Substitution - coding silent
c.2224G>C; p.E742Q; 2:74887907-74887907	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2428G>C; p.E810Q; 2:74889297-74889297	urinary_tract; bladder	carcinoma	Substitution - Missense
c.300T>C; p.N100N; 2:74867709-74867709	liver	carcinoma	Substitution - coding silent
c.11C>T; p.S4L; 2:74834591-74834591	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.11C>T; p.S4L; 2:74834591-74834591	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2170G>A; p.E724K; 2:74886624-74886624	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2703G>A; p.A901A; 2:74890890-74890890	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.125G>A; p.R42Q; 2:74854354-74854354	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1941T>A; p.F647L; 2:74886299-74886299	kidney	other; neoplasm	Substitution - Missense
c.2087T>A; p.V696E; 2:74886541-74886541	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.2087T>A; p.V696E; 2:74886541-74886541	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.125G>A; p.R42Q; 2:74854354-74854354	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1941T>A; p.F647L; 2:74886299-74886299	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2273T>C; p.L758P; 2:74887956-74887956	skin	malignant_melanoma	Substitution - Missense
c.906delG; p.E304fs*3; 2:74877196-74877196	liver	carcinoma	Deletion - Frameshift
c.985C>T; p.L329F; 2:74877275-74877275	skin	malignant_melanoma	Substitution - Missense
c.1685T>C; p.I562T; 2:74881825-74881825	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2264G>A; p.R755H; 2:74887947-74887947	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.2264G>A; p.R755H; 2:74887947-74887947	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2670C>T; p.F890F; 2:74890857-74890857	skin	malignant_melanoma	Substitution - coding silent
c.2670C>T; p.F890F; 2:74890857-74890857	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2628T>C; p.H876H; 2:74890815-74890815	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1603G>T; p.G535*; 2:74881743-74881743	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1329C>T; p.L443L; 2:74880328-74880328	breast	carcinoma	Substitution - coding silent
c.2587A>G; p.T863A; 2:74889456-74889456	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2142C>A; p.D714E; 2:74886596-74886596	lung	carcinoma	Substitution - Missense
c.391G>T; p.A131S; 2:74872315-74872315	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1687C>T; p.P563S; 2:74881827-74881827	skin	malignant_melanoma	Substitution - Missense
c.2650C>T; p.P884S; 2:74890837-74890837	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.552C>T; p.D184D; 2:74873332-74873332	prostate	carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation