lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3092
Symbol	HIP1
Synonymous	HIP-I\|ILWEQ\|SHON
Full name	huntingtin interacting protein 1
Gene description	huntingtin-interacting protein 1\|huntingtin-interacting protein I
Cytoband	7q11.23
Gene type	protein-coding
Synonymous	MIM:601767; HGNC:HGNC:4913; Ensembl:ENSG00000127946; HPRD:03461; Vega:OTTHUMG00000156050

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.397G>A; p.E133K; 7:75586821-75586821	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1322G>T; p.R441M; 7:75559785-75559785	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1547C>T; p.S516L; 7:75557688-75557688	skin	malignant_melanoma	Substitution - Missense
c.1547C>T; p.S516L; 7:75557688-75557688	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2776G>A; p.D926N; 7:75542965-75542965	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1704C>T; p.A568A; 7:75556149-75556149	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1070G>A; p.S357N; 7:75562121-75562121	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.851G>A; p.R284Q; 7:75563216-75563216	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1636C>T; p.Q546*; 7:75556757-75556757	prostate	carcinoma	Substitution - Nonsense
c.2329G>C; p.E777Q; 7:75548968-75548968	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.853C>T; p.L285F; 7:75563214-75563214	stomach	adenocarcinoma	Substitution - Missense
c.2904C>G; p.F968L; 7:75541967-75541967	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2184T>C; p.Y728Y; 7:75553564-75553564	bone; femur	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2088C>G; p.A696A; 7:75554183-75554183	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2218G>A; p.E740K; 7:75553530-75553530	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.85G>C; p.E29Q; 7:75738836-75738836	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2157C>A; p.D719E; 7:75554114-75554114	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2198T>C; p.L733P; 7:75553550-75553550	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2932C>T; p.R978C; 7:75541939-75541939	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1390A>G; p.N464D; 7:75558241-75558241	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2172C>T; p.A724A; 7:75553576-75553576	skin	malignant_melanoma	Substitution - coding silent
c.2722C>T; p.H908Y; 7:75544739-75544739	skin	malignant_melanoma	Substitution - Missense
c.149C>T; p.T50M; 7:75599219-75599219	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2142A>C; p.P714P; 7:75554129-75554129	breast	carcinoma	Substitution - coding silent
c.1377G>A; p.R459R; 7:75558254-75558254	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1081A>G; p.N361D; 7:75562110-75562110	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1377G>A; p.R459R; 7:75558254-75558254	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2953G>C; p.V985L; 7:75539431-75539431	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1556G>A; p.R519H; 7:75557679-75557679	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.178G>A; p.A60T; 7:75599190-75599190	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1093C>G; p.Q365E; 7:75562098-75562098	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2953-1G>T; p.?; 7:75539432-75539432	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Unknown
c.144T>G; p.I48M; 7:75599224-75599224	skin	malignant_melanoma	Substitution - Missense
c.120+9G>A; p.?; 7:75738792-75738792	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.1376-1G>T; p.?; 7:75558256-75558256	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1593G>A; p.Q531Q; 7:75556800-75556800	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1523G>A; p.R508Q; 7:75557712-75557712	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.703C>T; p.L235F; 7:75573803-75573803	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1570G>T; p.G524C; 7:75557665-75557665	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1729C>T; p.R577W; 7:75556124-75556124	breast	carcinoma	Substitution - Missense
c.2627C>T; p.S876F; 7:75545121-75545121	skin	malignant_melanoma	Substitution - Missense
c.3102C>T; p.T1034T; 7:75538184-75538184	skin	malignant_melanoma	Substitution - coding silent
c.2921C>A; p.T974K; 7:75541950-75541950	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2645G>T; p.G882V; 7:75545103-75545103	liver	carcinoma	Substitution - Missense
c.2645G>T; p.G882V; 7:75545103-75545103	liver	carcinoma	Substitution - Missense
c.2884G>T; p.E962*; 7:75542857-75542857	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1376G>A; p.R459K; 7:75558255-75558255	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2952+1G>T; p.?; 7:75541918-75541918	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.2906C>G; p.S969*; 7:75541965-75541965	ovary	other; neoplasm	Substitution - Nonsense
c.2943G>T; p.M981I; 7:75541928-75541928	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.245G>A; p.R82H; 7:75592454-75592454	pancreas	carcinoma	Substitution - Missense
c.2916G>T; p.T972T; 7:75541955-75541955	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1279G>A; p.A427T; 7:75559828-75559828	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1249G>A; p.A417T; 7:75559858-75559858	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2960T>G; p.V987G; 7:75539424-75539424	breast	carcinoma	Substitution - Missense
c.2928C>A; p.I976I; 7:75541943-75541943	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.294G>A; p.V98V; 7:75592405-75592405	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.752C>A; p.P251Q; 7:75568250-75568250	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2309G>A; p.R770K; 7:75548988-75548988	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.298C>T; p.H100Y; 7:75592401-75592401	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.164T>A; p.V55E; 7:75599204-75599204	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2336T>C; p.L779P; 7:75548961-75548961	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2993G>A; p.R998H; 7:75539391-75539391	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2322C>G; p.I774M; 7:75548975-75548975	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.123T>C; p.T41T; 7:75599245-75599245	large_intestine; colon	NS	Substitution - coding silent
c.2200G>A; p.A734T; 7:75553548-75553548	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.835C>T; p.L279L; 7:75563232-75563232	skin	malignant_melanoma	Substitution - coding silent
c.963C>T; p.P321P; 7:75562992-75562992	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1270C>A; p.Q424K; 7:75559837-75559837	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1189G>C; p.E397Q; 7:75561331-75561331	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2592G>T; p.K864N; 7:75545156-75545156	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2845G>A; p.V949I; 7:75542896-75542896	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.775C>A; p.R259R; 7:75568227-75568227	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - coding silent
c.3020A>G; p.K1007R; 7:75539364-75539364	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1281C>T; p.A427A; 7:75559826-75559826	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1281C>T; p.A427A; 7:75559826-75559826	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.850C>T; p.R284W; 7:75563217-75563217	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.2379T>A; p.A793A; 7:75548918-75548918	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2603G>T; p.W868L; 7:75545145-75545145	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2445C>T; p.V815V; 7:75547775-75547775	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2478C>T; p.C826C; 7:75547020-75547020	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2292C>T; p.G764G; 7:75553456-75553456	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2295+2T>C; p.?; 7:75553451-75553451	stomach	carcinoma; adenocarcinoma	Unknown
c.1075C>T; p.P359S; 7:75562116-75562116	skin	malignant_melanoma	Substitution - Missense
c.962C>T; p.P321L; 7:75562993-75562993	skin	malignant_melanoma	Substitution - Missense
c.1391A>G; p.N464S; 7:75558240-75558240	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2693G>T; p.G898V; 7:75544768-75544768	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2496A>G; p.Q832Q; 7:75547002-75547002	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2693G>T; p.G898V; 7:75544768-75544768	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1781T>C; p.L594P; 7:75556072-75556072	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1988C>T; p.S663F; 7:75554502-75554502	skin	malignant_melanoma	Substitution - Missense
c.287G>A; p.C96Y; 7:75592412-75592412	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.523G>T; p.E175*; 7:75582094-75582094	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1980G>A; p.T660T; 7:75554510-75554510	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.770G>A; p.G257D; 7:75568232-75568232	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1548G>A; p.S516S; 7:75557687-75557687	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.687C>G; p.I229M; 7:75573819-75573819	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.518C>T; p.A173V; 7:75582099-75582099	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2102A>G; p.D701G; 7:75554169-75554169	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.2265C>A; p.N755K; 7:75553483-75553483	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2289C>T; p.I763I; 7:75553459-75553459	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2967G>T; p.E989D; 7:75539417-75539417	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2213C>A; p.S738Y; 7:75553535-75553535	breast	carcinoma	Substitution - Missense
c.1804C>T; p.Q602*; 7:75556049-75556049	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Nonsense
c.1230C>T; p.S410S; 7:75559877-75559877	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2739C>G; p.S913R; 7:75544722-75544722	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2309G>T; p.R770M; 7:75548988-75548988	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3101C>T; p.T1034I; 7:75538185-75538185	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.132C>G; p.I44M; 7:75599236-75599236	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1145G>C; p.R382T; 7:75561375-75561375	urinary_tract; bladder	carcinoma	Substitution - Missense
c.132C>G; p.I44M; 7:75599236-75599236	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2572C>G; p.P858A; 7:75545176-75545176	breast	carcinoma	Substitution - Missense
c.2840C>T; p.A947V; 7:75542901-75542901	pancreas	NS	Substitution - Missense
c.2731G>T; p.A911S; 7:75544730-75544730	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.385-7C>T; p.?; 7:75586840-75586840	liver	carcinoma	Unknown
c.385-7C>T; p.?; 7:75586840-75586840	liver	carcinoma	Unknown
c.2844C>T; p.G948G; 7:75542897-75542897	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2653G>A; p.V885I; 7:75545095-75545095	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2653G>A; p.V885I; 7:75545095-75545095	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.2769G>A; p.V923V; 7:75542972-75542972	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2926A>G; p.I976V; 7:75541945-75541945	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1588G>T; p.E530*; 7:75556805-75556805	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.614C>T; p.S205F; 7:75573892-75573892	skin	malignant_melanoma	Substitution - Missense
c.2307C>T; p.P769P; 7:75548990-75548990	skin	malignant_melanoma	Substitution - coding silent
c.2720C>T; p.S907F; 7:75544741-75544741	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2584T>C; p.Y862H; 7:75545164-75545164	skin	malignant_melanoma	Substitution - Missense
c.1095A>T; p.Q365H; 7:75562096-75562096	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2600G>C; p.R867P; 7:75545148-75545148	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.837G>A; p.L279L; 7:75563230-75563230	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.1828-7T>G; p.?; 7:75555558-75555558	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.2572C>T; p.P858S; 7:75545176-75545176	skin	malignant_melanoma	Substitution - Missense
c.1453C>T; p.L485L; 7:75558178-75558178	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2370T>G; p.T790T; 7:75548927-75548927	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1950C>T; p.C650C; 7:75555429-75555429	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.712T>C; p.Y238H; 7:75573794-75573794	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1307A>T; p.E436V; 7:75559800-75559800	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.141C>T; p.A47A; 7:75599227-75599227	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.776G>A; p.R259Q; 7:75568226-75568226	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.776G>A; p.R259Q; 7:75568226-75568226	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1180A>T; p.M394L; 7:75561340-75561340	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2597C>T; p.S866F; 7:75545151-75545151	skin	malignant_melanoma	Substitution - Missense
c.632C>T; p.S211F; 7:75573874-75573874	skin	malignant_melanoma	Substitution - Missense
c.972G>A; p.E324E; 7:75562983-75562983	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.972G>A; p.E324E; 7:75562983-75562983	breast	carcinoma	Substitution - coding silent
c.2399G>A; p.R800K; 7:75548898-75548898	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2311G>A; p.G771R; 7:75548986-75548986	skin	malignant_melanoma	Substitution - Missense
c.876T>C; p.P292P; 7:75563191-75563191	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.3067G>C; p.E1023Q; 7:75538219-75538219	breast	carcinoma	Substitution - Missense
c.644C>G; p.T215R; 7:75573862-75573862	urinary_tract; bladder	carcinoma	Substitution - Missense
c.644C>G; p.T215R; 7:75573862-75573862	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.186G>A; p.T62T; 7:75592513-75592513	breast	carcinoma	Substitution - coding silent
c.644C>T; p.T215M; 7:75573862-75573862	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.58A>T; p.S20C; 7:75738863-75738863	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1391A>C; p.N464T; 7:75558240-75558240	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1853A>G; p.D618G; 7:75555526-75555526	pancreas	carcinoid-endocrine_tumour; islet_cell	Substitution - Missense
c.1198C>T; p.R400W; 7:75559909-75559909	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2790C>T; p.P930P; 7:75542951-75542951	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1710C>T; p.F570F; 7:75556143-75556143	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2415C>A; p.L805L; 7:75547805-75547805	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1710C>T; p.F570F; 7:75556143-75556143	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.297C>T; p.F99F; 7:75592402-75592402	skin	malignant_melanoma	Substitution - coding silent
c.2333A>G; p.E778G; 7:75548964-75548964	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.3055G>C; p.E1019Q; 7:75539329-75539329	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.916G>T; p.E306*; 7:75563039-75563039	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.830G>A; p.S277N; 7:75563237-75563237	lung	carcinoma	Substitution - Missense
c.1696T>C; p.W566R; 7:75556157-75556157	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.830G>A; p.S277N; 7:75563237-75563237	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.751C>T; p.P251S; 7:75568251-75568251	skin	malignant_melanoma	Substitution - Missense
c.1639C>T; p.R547W; 7:75556754-75556754	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2971G>T; p.E991*; 7:75539413-75539413	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.3038G>T; p.G1013V; 7:75539346-75539346	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.660C>T; p.C220C; 7:75573846-75573846	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.914C>G; p.S305*; 7:75563041-75563041	breast	carcinoma	Substitution - Nonsense
c.757G>A; p.D253N; 7:75568245-75568245	breast	carcinoma	Substitution - Missense
c.1858C>T; p.R620*; 7:75555521-75555521	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.996C>A; p.L332L; 7:75562959-75562959	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1225G>A; p.V409I; 7:75559882-75559882	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2131C>A; p.L711I; 7:75554140-75554140	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation