lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	306
Symbol	ANXA3
Synonymous	ANX3
Full name	annexin A3
Gene description	35-alpha calcimedin\|Annexin III (lipocortin III)\|PAP-III\|annexin III (lipocortin III, 1,2-cyclic-inositol-phosphate phosphodiesterase, placental anticoagulant protein III, calcimedin 35-alpha)\|annexin-3\|calcimedin 35-alpha\|inositol 1,2-cyclic phosphate 2-
Cytoband	4q21.21
Gene type	protein-coding
Synonymous	MIM:106490; HGNC:HGNC:541; Ensembl:ENSG00000138772; HPRD:00111; Vega:OTTHUMG00000130198

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.386C>T; p.S129F; 4:78586333-78586333	skin	malignant_melanoma	Substitution - Missense
c.793A>G; p.I265V; 4:78604280-78604280	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.923C>T; p.S308F; 4:78610066-78610066	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.300G>A; p.K100K; 4:78582278-78582278	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.327C>T; p.N109N; 4:78586274-78586274	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.59C>T; p.P20L; 4:78573223-78573223	NS	malignant_melanoma	Substitution - Missense
c.457C>T; p.R153W; 4:78591597-78591597	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.635-1G>T; p.?; 4:78597318-78597318	lung	carcinoma; adenocarcinoma	Unknown
c.904G>A; p.A302T; 4:78604391-78604391	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.703C>T; p.H235Y; 4:78597387-78597387	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.243G>A; p.E81E; 4:78582221-78582221	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.92T>C; p.I31T; 4:78573256-78573256	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.851T>C; p.L284P; 4:78604338-78604338	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.514G>A; p.E172K; 4:78595411-78595411	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.514G>A; p.E172K; 4:78595411-78595411	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.204G>T; p.L68L; 4:78582182-78582182	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.957T>C; p.C319C; 4:78610100-78610100	central_nervous_system; brain	glioma	Substitution - coding silent
c.300G>T; p.K100N; 4:78582278-78582278	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.157C>T; p.R53W; 4:78579080-78579080	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.757delT; p.L254fs*1; 4:78601536-78601536	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.962G>A; p.G321E; 4:78610105-78610105	liver	carcinoma	Substitution - Missense
c.757delT; p.L254fs*1; 4:78601536-78601536	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.962G>A; p.G321E; 4:78610105-78610105	liver	carcinoma	Substitution - Missense
c.328G>A; p.E110K; 4:78586275-78586275	skin	malignant_melanoma	Substitution - Missense
c.233G>T; p.G78V; 4:78582211-78582211	liver	carcinoma	Substitution - Missense
c.233G>T; p.G78V; 4:78582211-78582211	liver	carcinoma	Substitution - Missense
c.657C>T; p.I219I; 4:78597341-78597341	skin	malignant_melanoma	Substitution - coding silent
c.897A>G; p.L299L; 4:78604384-78604384	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.799A>G; p.T267A; 4:78604286-78604286	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.522G>A; p.L174L; 4:78595419-78595419	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.458G>A; p.R153Q; 4:78591598-78591598	skin	malignant_melanoma	Substitution - Missense
c.458G>A; p.R153Q; 4:78591598-78591598	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.714C>T; p.D238D; 4:78597398-78597398	upper_aerodigestive_tract; larynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.268C>A; p.P90T; 4:78582246-78582246	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.789+1G>A; p.?; 4:78601569-78601569	large_intestine; rectum	carcinoma; adenocarcinoma	Unknown
c.786G>C; p.L262F; 4:78601565-78601565	breast	carcinoma	Substitution - Missense
c.238T>A; p.F80I; 4:78582216-78582216	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.104G>C; p.G35A; 4:78579027-78579027	breast	carcinoma	Substitution - Missense
c.666G>T; p.K222N; 4:78597350-78597350	liver	carcinoma	Substitution - Missense
c.703C>A; p.H235N; 4:78597387-78597387	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.316G>A; p.A106T; 4:78586263-78586263	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.779G>A; p.R260Q; 4:78601558-78601558	skin; leg	malignant_melanoma	Substitution - Missense
c.779G>A; p.R260Q; 4:78601558-78601558	skin; leg	malignant_melanoma	Substitution - Missense
c.4G>A; p.A2T; 4:78554477-78554477	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.801T>G; p.T267T; 4:78604288-78604288	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.963A>T; p.G321G; 4:78610106-78610106	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.505A>G; p.K169E; 4:78595402-78595402	breast	carcinoma	Substitution - Missense
c.20G>C; p.G7A; 4:78573184-78573184	parathyroid	carcinoma	Substitution - Missense
c.820C>T; p.R274*; 4:78604307-78604307	skin	malignant_melanoma	Substitution - Nonsense
c.302A>C; p.K101T; 4:78582280-78582280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.446C>G; p.S149C; 4:78591586-78591586	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.718C>A; p.L240M; 4:78597402-78597402	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.944T>C; p.L315P; 4:78610087-78610087	prostate	carcinoma	Substitution - Missense
c.119T>G; p.M40R; 4:78579042-78579042	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.603G>A; p.L201L; 4:78595856-78595856	thyroid	carcinoma	Substitution - coding silent
c.862C>A; p.R288R; 4:78604349-78604349	thyroid	carcinoma	Substitution - coding silent
c.225T>A; p.D75E; 4:78582203-78582203	large_intestine; colon	adenoma	Substitution - Missense
c.255G>T; p.V85V; 4:78582233-78582233	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.862C>T; p.R288*; 4:78604349-78604349	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.620C>T; p.P207L; 4:78595873-78595873	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.416G>T; p.S139I; 4:78591556-78591556	central_nervous_system; brain	glioma	Substitution - Missense
c.763G>A; p.A255T; 4:78601542-78601542	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.536C>T; p.A179V; 4:78595433-78595433	liver	carcinoma	Substitution - Missense
c.536C>T; p.A179V; 4:78595433-78595433	liver	carcinoma	Substitution - Missense
c.221G>A; p.G74D; 4:78582199-78582199	skin	malignant_melanoma	Substitution - Missense
c.498A>G; p.E166E; 4:78595395-78595395	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.158G>A; p.R53Q; 4:78579081-78579081	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.103+9T>C; p.?; 4:78573276-78573276	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.103+9T>C; p.?; 4:78573276-78573276	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.591C>A; p.F197L; 4:78595844-78595844	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.314G>C; p.G105A; 4:78586261-78586261	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.716T>C; p.L239S; 4:78597400-78597400	breast	carcinoma	Substitution - Missense
c.791G>A; p.G264D; 4:78604278-78604278	skin; acral	malignant_melanoma	Substitution - Missense
c.319G>T; p.G107*; 4:78586266-78586266	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Nonsense
c.753G>A; p.P251P; 4:78601532-78601532	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation