lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	3009
Symbol	HIST1H1B
Synonymous	H1\|H1.5\|H1B\|H1F5\|H1s-3
Full name	histone cluster 1, H1b
Gene description	H1 histone family, member 5\|histone 1, H1b\|histone H1.5\|histone H1a\|histone H1b\|histone H1s-3
Cytoband	6p22.1
Gene type	protein-coding
Synonymous	MIM:142711; HGNC:HGNC:4719; Ensembl:ENSG00000184357; HPRD:00821; Vega:OTTHUMG00000016139

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.114G>T; p.A38A; 6:27867416-27867416	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.430A>G; p.K144E; 6:27867100-27867100	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.444G>T; p.A148A; 6:27867086-27867086	breast	carcinoma	Substitution - coding silent
c.306T>G; p.T102T; 6:27867224-27867224	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.564G>C; p.K188N; 6:27866966-27866966	breast	carcinoma	Substitution - Missense
c.557C>T; p.A186V; 6:27866973-27866973	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.119G>A; p.G40E; 6:27867411-27867411	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.620A>G; p.K207R; 6:27866910-27866910	soft_tissue; blood_vessel	angiosarcoma	Substitution - Missense
c.125delC; p.P42fs*5; 6:27867405-27867405	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.224A>G; p.D75G; 6:27867306-27867306	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.224A>G; p.D75G; 6:27867306-27867306	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.302G>A; p.G101D; 6:27867228-27867228	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.218G>A; p.G73D; 6:27867312-27867312	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.183T>C; p.S61S; 6:27867347-27867347	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.444G>A; p.A148A; 6:27867086-27867086	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.209C>T; p.A70V; 6:27867321-27867321	breast	carcinoma	Substitution - Missense
c.80A>G; p.K27R; 6:27867450-27867450	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.491C>T; p.A164V; 6:27867039-27867039	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.80A>G; p.K27R; 6:27867450-27867450	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.352_353insG; p.E118fs*13; 6:27867177-27867178	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.636A>G; p.K212K; 6:27866894-27866894	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.379G>A; p.G127S; 6:27867151-27867151	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.297C>T; p.T99T; 6:27867233-27867233	skin	malignant_melanoma	Substitution - coding silent
c.259C>T; p.L87F; 6:27867271-27867271	skin	malignant_melanoma	Substitution - Missense
c.79A>T; p.K27*; 6:27867451-27867451	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.420G>A; p.K140K; 6:27867110-27867110	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.449A>G; p.K150R; 6:27867081-27867081	skin	malignant_melanoma	Substitution - Missense
c.449A>G; p.K150R; 6:27867081-27867081	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.257G>A; p.G86D; 6:27867273-27867273	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.634A>T; p.K212*; 6:27866896-27866896	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.480G>A; p.K160K; 6:27867050-27867050	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.679T>C; p.*227Q; 6:27866851-27866851	large_intestine; colon	carcinoma; adenocarcinoma	Nonstop extension
c.119G>T; p.G40V; 6:27867411-27867411	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.546A>C; p.K182N; 6:27866984-27866984	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.30C>T; p.A10A; 6:27867500-27867500	skin	malignant_melanoma	Substitution - coding silent
c.30C>T; p.A10A; 6:27867500-27867500	skin	malignant_melanoma	Substitution - coding silent
c.635A>G; p.K212R; 6:27866895-27866895	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.449delA; p.K150fs*3; 6:27867081-27867081	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.449delA; p.K150fs*3; 6:27867081-27867081	skin	malignant_melanoma	Deletion - Frameshift
c.449delA; p.K150fs*3; 6:27867081-27867081	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.675G>C; p.K225N; 6:27866855-27866855	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.675G>C; p.K225N; 6:27866855-27866855	liver	carcinoma	Substitution - Missense
c.410C>G; p.A137G; 6:27867120-27867120	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.485C>T; p.P162L; 6:27867045-27867045	skin	malignant_melanoma	Substitution - Missense
c.675G>C; p.K225N; 6:27866855-27866855	liver	carcinoma	Substitution - Missense
c.330C>G; p.L110L; 6:27867200-27867200	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.410C>G; p.A137G; 6:27867120-27867120	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.594G>A; p.P198P; 6:27866936-27866936	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.391G>A; p.A131T; 6:27867139-27867139	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.571_585del15; p.A191_A195delAKPKA; 6:27866945-27866959	prostate	carcinoma	Deletion - In frame
c.17C>T; p.P6L; 6:27867513-27867513	skin	malignant_melanoma	Substitution - Missense
c.283A>G; p.T95A; 6:27867247-27867247	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.369C>T; p.A123A; 6:27867161-27867161	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.234_236delGAA; p.K78delK; 6:27867294-27867296	oesophagus	carcinoma; adenocarcinoma	Deletion - In frame
c.138G>C; p.L46L; 6:27867392-27867392	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.662C>T; p.A221V; 6:27866868-27866868	prostate	carcinoma	Substitution - Missense
c.52T>A; p.S18T; 6:27867478-27867478	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.48G>A; p.E16E; 6:27867482-27867482	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.551A>G; p.K184R; 6:27866979-27866979	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.86C>G; p.A29G; 6:27867444-27867444	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.25A>G; p.T9A; 6:27867505-27867505	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.81G>A; p.K27K; 6:27867449-27867449	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.502delA; p.K169fs*>58; 6:27867028-27867028	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Deletion - Frameshift
c.502delA; p.K169fs*>58; 6:27867028-27867028	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Deletion - Frameshift
c.190G>T; p.A64S; 6:27867340-27867340	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.477G>A; p.A159A; 6:27867053-27867053	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.98C>A; p.A33D; 6:27867432-27867432	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.70G>A; p.A24T; 6:27867460-27867460	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.70G>A; p.A24T; 6:27867460-27867460	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.372G>A; p.K124K; 6:27867158-27867158	skin	malignant_melanoma	Substitution - coding silent
c.43G>T; p.V15L; 6:27867487-27867487	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.342G>T; p.A114A; 6:27867188-27867188	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.342G>T; p.A114A; 6:27867188-27867188	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.267C>T; p.S89S; 6:27867263-27867263	skin	malignant_melanoma	Substitution - coding silent
c.155C>T; p.A52V; 6:27867375-27867375	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.480G>C; p.K160N; 6:27867050-27867050	pancreas	carcinoma	Substitution - Missense
c.480G>C; p.K160N; 6:27867050-27867050	pancreas	carcinoma	Substitution - Missense
c.480G>C; p.K160N; 6:27867050-27867050	pancreas	carcinoma	Substitution - Missense
c.480G>C; p.K160N; 6:27867050-27867050	pancreas	carcinoma	Substitution - Missense
c.480G>C; p.K160N; 6:27867050-27867050	pancreas	carcinoma	Substitution - Missense
c.559A>G; p.T187A; 6:27866971-27866971	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.651G>C; p.K217N; 6:27866879-27866879	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.534G>C; p.K178N; 6:27866996-27866996	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.643G>A; p.A215T; 6:27866887-27866887	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.326A>G; p.K109R; 6:27867204-27867204	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.661G>A; p.A221T; 6:27866869-27866869	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.488C>A; p.A163E; 6:27867042-27867042	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.506A>T; p.K169M; 6:27867024-27867024	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.654C>G; p.A218A; 6:27866876-27866876	skin	malignant_melanoma	Substitution - coding silent
c.429G>C; p.K143N; 6:27867101-27867101	breast	carcinoma	Substitution - Missense
c.429G>C; p.K143N; 6:27867101-27867101	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.654C>G; p.A218A; 6:27866876-27866876	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.401C>T; p.P134L; 6:27867129-27867129	skin	malignant_melanoma	Substitution - Missense
c.198G>A; p.K66K; 6:27867332-27867332	skin	malignant_melanoma	Substitution - coding silent
c.461A>G; p.K154R; 6:27867069-27867069	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.170G>T; p.R57L; 6:27867360-27867360	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.474G>A; p.K158K; 6:27867056-27867056	skin	malignant_melanoma	Substitution - coding silent
c.525G>A; p.K175K; 6:27867005-27867005	skin	malignant_melanoma	Substitution - coding silent
c.291G>A; p.V97V; 6:27867239-27867239	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.58G>T; p.A20S; 6:27867472-27867472	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.676_678delAAG; p.K226delK; 6:27866852-27866854	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.386C>T; p.A129V; 6:27867144-27867144	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.434C>T; p.A145V; 6:27867096-27867096	liver	carcinoma	Substitution - Missense
c.634A>G; p.K212E; 6:27866896-27866896	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.615_629del15; p.P213_K217delPKAAK; 6:27866901-27866915	lung	carcinoma; adenocarcinoma	Deletion - In frame
c.634A>G; p.K212E; 6:27866896-27866896	oesophagus	carcinoma	Substitution - Missense
c.653C>T; p.A218V; 6:27866877-27866877	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.281G>A; p.G94D; 6:27867249-27867249	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.573C>G; p.A191A; 6:27866957-27866957	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3G>T; p.M1I; 6:27867527-27867527	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.616G>A; p.A206T; 6:27866914-27866914	urinary_tract; bladder	carcinoma	Substitution - Missense
c.222C>T; p.Y74Y; 6:27867308-27867308	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.147G>T; p.K49N; 6:27867383-27867383	lung	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation