Cancer metastasis database

Annotation category 5

Gene information

Gene ID 29851
Symbol

ICOS

Synonymous

AILIM|CD278|CVID1

Full name

inducible T-cell co-stimulator

Gene description

activation-inducible lymphocyte immunomediatory molecule|inducible T-cell costimulator|inducible costimulator

Cytoband

2q33

Gene type

protein-coding

Synonymous

MIM:604558; HGNC:HGNC:5351; Ensembl:ENSG00000163600; HPRD:09196; Vega:OTTHUMG00000132880

COSMIC somatic mutation

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.208G>A; p.G70R; 2:203955785-203955785

 skinmalignant_melanomaSubstitution - Missense

c.147G>T; p.Q49H; 2:203955724-203955724

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.402A>C; p.Q134H; 2:203956666-203956666

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.190G>A; p.D64N; 2:203955767-203955767

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.190G>A; p.D64N; 2:203955767-203955767

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.587-1G>T; p.?; 2:203959585-203959585

 large_intestine; coloncarcinoma; adenocarcinomaUnknown

c.64A>T; p.I22F; 2:203955641-203955641

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.578G>A; p.R193K; 2:203957875-203957875

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.117A>C; p.Q39H; 2:203955694-203955694

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.58+1G>A; p.?; 2:203936873-203936873

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.173G>A; p.G58E; 2:203955750-203955750

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.171_172insG; p.Q60fs*8; 2:203955748-203955749

 breastcarcinomaInsertion - Frameshift

c.28C>A; p.L10I; 2:203936842-203936842

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.175G>A; p.G59R; 2:203955752-203955752

 breastcarcinomaSubstitution - Missense

c.577A>G; p.R193G; 2:203957874-203957874

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.133C>T; p.P45S; 2:203955710-203955710

 skinmalignant_melanomaSubstitution - Missense

c.215G>A; p.G72E; 2:203955792-203955792

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.295T>G; p.L99V; 2:203955872-203955872

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.572A>C; p.K191T; 2:203957869-203957869

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.244T>C; p.F82L; 2:203955821-203955821

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.517G>A; p.V173M; 2:203957814-203957814

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.501+6C>T; p.?; 2:203956771-203956771

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaUnknown

c.85G>A; p.E29K; 2:203955662-203955662

 breastcarcinomaSubstitution - Missense

c.226T>C; p.S76P; 2:203955803-203955803

 breastcarcinomaSubstitution - Missense

c.226T>C; p.S76P; 2:203955803-203955803

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.535G>A; p.E179K; 2:203957832-203957832

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.494delC; p.T165fs*19; 2:203956758-203956758

 lungcarcinoma; adenocarcinomaDeletion - Frameshift

c.242A>T; p.K81I; 2:203955819-203955819

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.41G>A; p.R14H; 2:203936855-203936855

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.41G>A; p.R14H; 2:203936855-203936855

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.593delC; p.L199fs?; 2:203959592-203959592

 lungcarcinoma; adenocarcinomaDeletion - Frameshift

c.347C>A; p.P116H; 2:203955924-203955924

 ovarycarcinomaSubstitution - Missense

c.140T>C; p.I47T; 2:203955717-203955717

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.563C>G; p.T188R; 2:203957860-203957860

 ovarycarcinoma; serous_carcinomaSubstitution - Missense