lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2922
Symbol	GRP
Synonymous	BN\|GRP-10\|preproGRP\|proGRP
Full name	gastrin-releasing peptide
Gene description	bombesin\|neuromedin C\|pre-progastrin releasing peptide\|prepro-GRP
Cytoband	18q21.1-q21.32
Gene type	protein-coding
Synonymous	MIM:137260; HGNC:HGNC:4605; Ensembl:ENSG00000134443; HPRD:08845; Vega:OTTHUMG00000132760

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.314G>A; p.G105D; 18:59225666-59225666	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.438C>G; p.N146K; 18:59230459-59230459	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.163A>G; p.T55A; 18:59225515-59225515	breast	carcinoma	Substitution - Missense
c.244A>C; p.R82R; 18:59225596-59225596	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.228G>T; p.R76S; 18:59225580-59225580	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.232G>A; p.E78K; 18:59225584-59225584	skin	malignant_melanoma	Substitution - Missense
c.422_425delGGAA; p.R141fs*4; 18:59230443-59230446	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Deletion - Frameshift
c.422_425delGGAA; p.R141fs*4; 18:59230443-59230446	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Deletion - Frameshift
c.422_425delGGAA; p.R141fs*4; 18:59230443-59230446	large_intestine; colon	carcinoma	Deletion - Frameshift
c.422_425delGGAA; p.R141fs*4; 18:59230443-59230446	kidney	carcinoma; renal_cell_carcinoma	Deletion - Frameshift
c.422_425delGGAA; p.R141fs*4; 18:59230443-59230446	kidney	carcinoma; renal_cell_carcinoma	Deletion - Frameshift
c.422_425delGGAA; p.R141fs*4; 18:59230443-59230446	ovary	carcinoma; adenocarcinoma	Deletion - Frameshift
c.143A>G; p.H48R; 18:59225495-59225495	liver	carcinoma	Substitution - Missense
c.229T>G; p.W77G; 18:59225581-59225581	breast	carcinoma	Substitution - Missense
c.301C>A; p.P101T; 18:59225653-59225653	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.116C>T; p.P39L; 18:59220381-59220381	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.338C>A; p.S113*; 18:59225690-59225690	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.217G>T; p.E73*; 18:59225569-59225569	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.88G>A; p.G30R; 18:59220353-59220353	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.263T>C; p.I88T; 18:59225615-59225615	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.259C>T; p.L87F; 18:59225611-59225611	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.305A>G; p.K102R; 18:59225657-59225657	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.188A>C; p.E63A; 18:59225540-59225540	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.310C>A; p.L104M; 18:59225662-59225662	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.397G>A; p.A133T; 18:59230418-59230418	genital_tract; extragonadal	germ_cell_tumour; seminoma	Substitution - Missense
c.6C>T; p.R2R; 18:59220271-59220271	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.302C>T; p.P101L; 18:59225654-59225654	skin	malignant_melanoma	Substitution - Missense
c.334G>A; p.D112N; 18:59225686-59225686	skin	malignant_melanoma	Substitution - Missense
c.145T>G; p.L49V; 18:59225497-59225497	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.357C>G; p.F119L; 18:59225709-59225709	breast	carcinoma	Substitution - Missense
c.377G>A; p.G126D; 18:59225729-59225729	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.245G>A; p.R82K; 18:59225597-59225597	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.135G>C; p.A45A; 18:59220400-59220400	pancreas	carcinoma	Substitution - coding silent
c.10C>A; p.R4S; 18:59220275-59220275	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.10C>A; p.R4S; 18:59220275-59220275	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.10C>A; p.R4S; 18:59220275-59220275	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.10C>A; p.R4S; 18:59220275-59220275	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.10C>A; p.R4S; 18:59220275-59220275	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.10C>A; p.R4S; 18:59220275-59220275	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.10C>A; p.R4S; 18:59220275-59220275	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.10C>A; p.R4S; 18:59220275-59220275	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.10C>A; p.R4S; 18:59220275-59220275	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.10C>A; p.R4S; 18:59220275-59220275	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.10C>A; p.R4S; 18:59220275-59220275	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.10C>A; p.R4S; 18:59220275-59220275	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.10C>A; p.R4S; 18:59220275-59220275	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation