lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	29108
Symbol	PYCARD
Synonymous	ASC\|CARD5\|TMS\|TMS-1\|TMS1
Full name	PYD and CARD domain containing
Gene description	apoptosis-associated speck-like protein containing a CARD\|caspase recruitment domain-containing protein 5\|target of methylation-induced silencing 1
Cytoband	16p11.2
Gene type	protein-coding
Synonymous	MIM:606838; HGNC:HGNC:16608; Ensembl:ENSG00000103490; HPRD:06020; Vega:OTTHUMG00000176753

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.411C>A; p.Y137*; 16:31201762-31201762	pancreas	carcinoma	Substitution - Nonsense
c.237G>T; p.Q79H; 16:31202454-31202454	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.100G>A; p.E34K; 16:31202591-31202591	NS	NS	Substitution - Missense
c.352C>A; p.H118N; 16:31201821-31201821	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.285C>T; p.A95A; 16:31202193-31202193	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.55G>T; p.E19*; 16:31202636-31202636	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.45G>A; p.L15L; 16:31202646-31202646	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - coding silent
c.318G>A; p.S106S; 16:31202160-31202160	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.433C>T; p.Q145*; 16:31201740-31201740	breast	carcinoma	Substitution - Nonsense
c.349C>A; p.Q117K; 16:31201824-31201824	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.478C>T; p.R160W; 16:31201695-31201695	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.438C>T; p.Y146Y; 16:31201735-31201735	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.535C>T; p.Q179*; 16:31201638-31201638	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.484C>T; p.L162F; 16:31201689-31201689	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.585C>A; p.S195R; 16:31201588-31201588	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.304G>A; p.A102T; 16:31202174-31202174	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.276C>A; p.G92G; 16:31202202-31202202	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.474G>C; p.K158N; 16:31201699-31201699	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.513G>C; p.W171C; 16:31201660-31201660	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense