lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	29102
Symbol	DROSHA
Synonymous	ETOHI2\|HSA242976\|RANSE3L\|RN3\|RNASE3L\|RNASEN
Full name	drosha, ribonuclease type III
Gene description	RNase III\|drosha, double-stranded RNA-specific endoribonuclease\|nuclear RNase III Drosha\|p241\|protein Drosha\|putative protein p241 which interacts with transcription factor Sp1\|putative ribonuclease III\|ribonuclease 3\|ribonuclease III, nuclear\|ribonucleas
Cytoband	5p13.3
Gene type	protein-coding
Synonymous	MIM:608828; HGNC:HGNC:17904; Ensembl:ENSG00000113360; HPRD:10196; Vega:OTTHUMG00000161976

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.2401C>T; p.R801C; 5:31466247-31466247	skin	malignant_melanoma	Substitution - Missense
c.2020_2021CC>AT; p.P674I; 5:31483604-31483605	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.219T>C; p.P73P; 5:31526714-31526714	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3223C>T; p.R1075C; 5:31424465-31424465	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.28A>G; p.M10V; 5:31526905-31526905	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.300G>A; p.P100P; 5:31526633-31526633	endometrium	carcinoma; serous_carcinoma	Substitution - coding silent
c.337G>T; p.V113F; 5:31526596-31526596	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2410C>T; p.L804L; 5:31466238-31466238	skin	malignant_melanoma	Substitution - coding silent
c.3439G>A; p.E1147K; 5:31421358-31421358	kidney	Wilms_tumour	Substitution - Missense
c.3439G>A; p.E1147K; 5:31421358-31421358	kidney	Wilms_tumour	Substitution - Missense
c.1290+1G>A; p.?; 5:31514987-31514987	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.835C>T; p.R279C; 5:31526098-31526098	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.396C>T; p.V132V; 5:31526537-31526537	skin	malignant_melanoma	Substitution - coding silent
c.396C>T; p.V132V; 5:31526537-31526537	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.835C>T; p.R279C; 5:31526098-31526098	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1782C>T; p.Y594Y; 5:31493267-31493267	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.4070G>T; p.W1357L; 5:31401487-31401487	breast	carcinoma	Substitution - Missense
c.1146G>C; p.K382N; 5:31515132-31515132	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1782C>T; p.Y594Y; 5:31493267-31493267	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2985A>T; p.G995G; 5:31435822-31435822	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3511G>A; p.E1171K; 5:31421286-31421286	liver	carcinoma	Substitution - Missense
c.3511G>A; p.E1171K; 5:31421286-31421286	liver	carcinoma	Substitution - Missense
c.2668C>T; p.R890C; 5:31451547-31451547	NS	malignant_melanoma	Substitution - Missense
c.2668C>T; p.R890C; 5:31451547-31451547	NS	malignant_melanoma	Substitution - Missense
c.2668C>T; p.R890C; 5:31451547-31451547	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1102G>T; p.E368*; 5:31515176-31515176	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1617C>T; p.S539S; 5:31504606-31504606	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3681G>T; p.A1227A; 5:31409319-31409319	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1617C>T; p.S539S; 5:31504606-31504606	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1357G>T; p.G453W; 5:31511110-31511110	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2674C>T; p.L892L; 5:31451541-31451541	skin	malignant_melanoma	Substitution - coding silent
c.3940G>C; p.G1314R; 5:31406860-31406860	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1393C>T; p.P465S; 5:31511074-31511074	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1040_1041CC>TT; p.P347L; 5:31515471-31515472	skin; extremity	malignant_melanoma	Substitution - Missense
c.3451G>T; p.D1151Y; 5:31421346-31421346	kidney	Wilms_tumour	Substitution - Missense
c.1953C>A; p.F651L; 5:31484924-31484924	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3370C>T; p.L1124L; 5:31422836-31422836	skin	malignant_melanoma	Substitution - coding silent
c.2308C>T; p.P770S; 5:31467997-31467997	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1910C>G; p.P637R; 5:31486495-31486495	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.104G>T; p.R35M; 5:31526829-31526829	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.572C>A; p.S191Y; 5:31526361-31526361	NS	malignant_melanoma	Substitution - Missense
c.572C>A; p.S191Y; 5:31526361-31526361	NS	malignant_melanoma	Substitution - Missense
c.3633G>A; p.A1211A; 5:31410780-31410780	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1298C>A; p.S433Y; 5:31511169-31511169	thyroid	other; neoplasm	Substitution - Missense
c.457C>T; p.H153Y; 5:31526476-31526476	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1314G>A; p.T438T; 5:31511153-31511153	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.970C>T; p.P324S; 5:31515542-31515542	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4037_4038GG>AA; p.R1346Q; 5:31401519-31401520	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3080G>T; p.G1027V; 5:31431641-31431641	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.642G>C; p.K214N; 5:31526291-31526291	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1362C>T; p.S454S; 5:31511105-31511105	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1922G>C; p.C641S; 5:31484955-31484955	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.199C>T; p.P67S; 5:31526734-31526734	breast	carcinoma	Substitution - Missense
c.1450G>A; p.E484K; 5:31508758-31508758	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2319C>T; p.V773V; 5:31467986-31467986	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3032_3033insT; p.M1011fs*7; 5:31435774-31435775	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.936G>A; p.K312K; 5:31521134-31521134	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2283G>T; p.Q761H; 5:31468022-31468022	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3361G>T; p.V1121F; 5:31422845-31422845	skin	malignant_melanoma	Substitution - Missense
c.3637C>T; p.R1213C; 5:31410776-31410776	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3509A>G; p.H1170R; 5:31421288-31421288	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3197G>A; p.R1066H; 5:31429494-31429494	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.223C>T; p.R75*; 5:31526710-31526710	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.3197G>A; p.R1066H; 5:31429494-31429494	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3062T>G; p.F1021C; 5:31431659-31431659	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1060C>T; p.R354C; 5:31515218-31515218	skin	malignant_melanoma	Substitution - Missense
c.3835C>A; p.P1279T; 5:31409075-31409075	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3835C>A; p.P1279T; 5:31409075-31409075	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3835C>A; p.P1279T; 5:31409075-31409075	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1834delC; p.L612fs*1; 5:31493215-31493215	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2789G>C; p.R930T; 5:31449313-31449313	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.3572C>T; p.A1191V; 5:31410841-31410841	oesophagus	carcinoma	Substitution - Missense
c.154C>T; p.Q52*; 5:31526779-31526779	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2502_2503GA>AT; p.M834_R835>I*; 5:31464307-31464308	lung; right_upper_lobe	carcinoma; adenocarcinoma	Complex - compound substitution
c.1631G>A; p.R544H; 5:31504592-31504592	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1206G>A; p.E402E; 5:31515072-31515072	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.224G>A; p.R75Q; 5:31526709-31526709	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.224G>A; p.R75Q; 5:31526709-31526709	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3646A>T; p.T1216S; 5:31410767-31410767	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.3007A>G; p.I1003V; 5:31435800-31435800	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1287G>A; p.Q429Q; 5:31514991-31514991	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.110A>C; p.Q37P; 5:31526823-31526823	breast	carcinoma	Substitution - Missense
c.3635T>G; p.L1212R; 5:31410778-31410778	liver	carcinoma	Substitution - Missense
c.248C>T; p.P83L; 5:31526685-31526685	urinary_tract; bladder	carcinoma	Substitution - Missense
c.3635T>G; p.L1212R; 5:31410778-31410778	liver	carcinoma	Substitution - Missense
c.1146G>T; p.K382N; 5:31515132-31515132	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1825C>T; p.H609Y; 5:31493224-31493224	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2107C>A; p.L703I; 5:31472197-31472197	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2835G>A; p.L945L; 5:31448594-31448594	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.444T>C; p.P148P; 5:31526489-31526489	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.719G>A; p.R240Q; 5:31526214-31526214	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2782G>A; p.G928R; 5:31449320-31449320	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.379C>T; p.P127S; 5:31526554-31526554	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2511A>G; p.E837E; 5:31464299-31464299	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.3715A>T; p.T1239S; 5:31409285-31409285	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2612G>A; p.R871H; 5:31451603-31451603	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.4032C>T; p.I1344I; 5:31401525-31401525	skin	malignant_melanoma	Substitution - coding silent
c.2551G>C; p.G851R; 5:31464259-31464259	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1241G>A; p.R414Q; 5:31515037-31515037	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.445C>T; p.P149S; 5:31526488-31526488	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1834_1835insC; p.L612fs*8; 5:31493214-31493215	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.248delC; p.P83fs*25; 5:31526685-31526685	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.3648C>T; p.T1216T; 5:31410765-31410765	skin	malignant_melanoma	Substitution - coding silent
c.737C>T; p.S246F; 5:31526196-31526196	central_nervous_system; brain	glioma	Substitution - Missense
c.646C>G; p.P216A; 5:31526287-31526287	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; polycythaemia_vera	Substitution - Missense
c.3564C>A; p.A1188A; 5:31410849-31410849	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.363A>G; p.P121P; 5:31526570-31526570	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.2482delA; p.I828fs*7; 5:31464328-31464328	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.3151G>A; p.V1051I; 5:31429540-31429540	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1090C>T; p.R364C; 5:31515188-31515188	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3819G>A; p.R1273R; 5:31409091-31409091	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2065C>A; p.L689I; 5:31483560-31483560	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.164C>T; p.P55L; 5:31526769-31526769	skin	malignant_melanoma	Substitution - Missense
c.427C>T; p.P143S; 5:31526506-31526506	skin	malignant_melanoma	Substitution - Missense
c.1670C>G; p.A557G; 5:31495371-31495371	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.428C>T; p.P143L; 5:31526505-31526505	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.460C>T; p.P154S; 5:31526473-31526473	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.883C>T; p.R295*; 5:31521187-31521187	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.3295G>T; p.E1099*; 5:31422911-31422911	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1740G>T; p.P580P; 5:31495301-31495301	lung; middle_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.4024C>T; p.R1342W; 5:31401533-31401533	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3080G>A; p.G1027E; 5:31431641-31431641	urinary_tract; bladder	carcinoma	Substitution - Missense
c.233T>G; p.F78C; 5:31526700-31526700	breast	carcinoma	Substitution - Missense
c.2272G>A; p.D758N; 5:31468033-31468033	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.3239A>T; p.N1080I; 5:31424449-31424449	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3268G>T; p.E1090*; 5:31422938-31422938	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Nonsense
c.2021C>T; p.P674L; 5:31483604-31483604	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.260C>A; p.P87Q; 5:31526673-31526673	liver	carcinoma	Substitution - Missense
c.1161C>G; p.I387M; 5:31515117-31515117	urinary_tract; bladder	carcinoma	Substitution - Missense
c.663C>T; p.S221S; 5:31526270-31526270	skin	malignant_melanoma	Substitution - coding silent
c.962C>T; p.S321L; 5:31515550-31515550	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1387C>T; p.R463W; 5:31511080-31511080	pancreas	carcinoma	Substitution - Missense
c.907C>T; p.L303L; 5:31521163-31521163	skin	malignant_melanoma	Substitution - coding silent
c.663C>A; p.S221S; 5:31526270-31526270	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1690A>G; p.M564V; 5:31495351-31495351	pancreas	carcinoma	Substitution - Missense
c.1028C>A; p.S343Y; 5:31515484-31515484	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1028C>A; p.S343Y; 5:31515484-31515484	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1180G>A; p.E394K; 5:31515098-31515098	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2005_2008delTTTG; p.F669fs*17; 5:31483617-31483620	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2257C>T; p.R753C; 5:31468048-31468048	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1400A>T; p.E467V; 5:31511067-31511067	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.3971C>G; p.A1324G; 5:31405700-31405700	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2332C>T; p.R778C; 5:31467973-31467973	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2332C>T; p.R778C; 5:31467973-31467973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2332C>T; p.R778C; 5:31467973-31467973	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.803A>T; p.D268V; 5:31526130-31526130	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3577G>T; p.E1193*; 5:31410836-31410836	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2574+1G>T; p.?; 5:31464235-31464235	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.294C>G; p.I98M; 5:31526639-31526639	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2796T>C; p.V932V; 5:31449306-31449306	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.701G>T; p.R234L; 5:31526232-31526232	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1709G>T; p.R570I; 5:31495332-31495332	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2156T>C; p.I719T; 5:31472148-31472148	urinary_tract; bladder	carcinoma	Substitution - Missense
c.3453C>A; p.D1151E; 5:31421344-31421344	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.216C>T; p.L72L; 5:31526717-31526717	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2028C>T; p.C676C; 5:31483597-31483597	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.914G>C; p.R305T; 5:31521156-31521156	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1298C>G; p.S433C; 5:31511169-31511169	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1529G>A; p.R510H; 5:31508679-31508679	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1587+1G>T; p.?; 5:31508620-31508620	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.854G>T; p.R285I; 5:31526079-31526079	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2512G>T; p.V838L; 5:31464298-31464298	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3881A>T; p.H1294L; 5:31406919-31406919	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.209A>G; p.N70S; 5:31526724-31526724	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3847C>G; p.L1283V; 5:31409063-31409063	breast	carcinoma	Substitution - Missense
c.843C>T; p.Y281Y; 5:31526090-31526090	breast	carcinoma	Substitution - coding silent
c.2316C>T; p.I772I; 5:31467989-31467989	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.62G>A; p.G21E; 5:31526871-31526871	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3284G>A; p.R1095Q; 5:31422922-31422922	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.4051G>C; p.E1351Q; 5:31401506-31401506	breast	carcinoma	Substitution - Missense
c.4030A>G; p.I1344V; 5:31401527-31401527	liver	carcinoma	Substitution - Missense
c.285delC; p.C96fs*12; 5:31526648-31526648	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.3306A>G; p.P1102P; 5:31422900-31422900	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.502T>C; p.Y168H; 5:31526431-31526431	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2888A>G; p.N963S; 5:31437293-31437293	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.899C>T; p.S300L; 5:31521171-31521171	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.175_176CC>TT; p.P59F; 5:31526757-31526758	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.391C>T; p.P131S; 5:31526542-31526542	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.451A>G; p.M151V; 5:31526482-31526482	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2610C>T; p.I870I; 5:31451605-31451605	skin	malignant_melanoma	Substitution - coding silent
c.1449C>T; p.S483S; 5:31508759-31508759	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.98C>T; p.S33F; 5:31526835-31526835	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.859C>T; p.R287*; 5:31521211-31521211	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.3653C>T; p.A1218V; 5:31410760-31410760	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.321G>A; p.M107I; 5:31526612-31526612	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3554G>T; p.R1185I; 5:31410859-31410859	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1340A>C; p.K447T; 5:31511127-31511127	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.811C>T; p.R271*; 5:31526122-31526122	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2240C>T; p.T747M; 5:31472064-31472064	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2451G>T; p.K817N; 5:31466197-31466197	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2850A>G; p.S950S; 5:31448579-31448579	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2240C>T; p.T747M; 5:31472064-31472064	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3194G>C; p.G1065A; 5:31429497-31429497	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1746G>A; p.T582T; 5:31495295-31495295	endometrium	carcinoma; serous_carcinoma	Substitution - coding silent
c.266C>T; p.A89V; 5:31526667-31526667	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1746G>A; p.T582T; 5:31495295-31495295	breast	carcinoma	Substitution - coding silent
c.4037G>A; p.R1346Q; 5:31401520-31401520	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1412C>T; p.T471M; 5:31511055-31511055	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.518C>G; p.S173C; 5:31526415-31526415	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1165G>A; p.E389K; 5:31515113-31515113	skin	malignant_melanoma	Substitution - Missense
c.1165G>A; p.E389K; 5:31515113-31515113	skin	malignant_melanoma	Substitution - Missense
c.3960G>A; p.A1320A; 5:31405711-31405711	skin	malignant_melanoma	Substitution - coding silent
c.1165G>A; p.E389K; 5:31515113-31515113	skin	malignant_melanoma	Substitution - Missense
c.389C>G; p.P130R; 5:31526544-31526544	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2093C>T; p.S698F; 5:31472211-31472211	skin	malignant_melanoma	Substitution - Missense
c.827C>G; p.S276C; 5:31526106-31526106	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2277_2278delTG; p.E760fs*47; 5:31468027-31468028	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.257C>A; p.P86H; 5:31526676-31526676	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1090C>A; p.R364S; 5:31515188-31515188	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2162A>G; p.N721S; 5:31472142-31472142	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.927A>G; p.K309K; 5:31521143-31521143	liver	carcinoma	Substitution - coding silent
c.1325G>A; p.R442H; 5:31511142-31511142	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4025G>A; p.R1342Q; 5:31401532-31401532	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.4025G>A; p.R1342Q; 5:31401532-31401532	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1645C>T; p.H549Y; 5:31504578-31504578	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2786A>T; p.D929V; 5:31449316-31449316	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.927delA; p.E310fs*42; 5:31521143-31521143	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2733T>C; p.D911D; 5:31449369-31449369	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.4025G>T; p.R1342L; 5:31401532-31401532	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3505C>A; p.H1169N; 5:31421292-31421292	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1884G>A; p.T628T; 5:31486521-31486521	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.656G>T; p.R219I; 5:31526277-31526277	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.545T>C; p.F182S; 5:31526388-31526388	breast	carcinoma	Substitution - Missense
c.470delC; p.P157fs*69; 5:31526463-31526463	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.3624G>A; p.R1208R; 5:31410789-31410789	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.4089G>T; p.E1363D; 5:31401468-31401468	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3542T>C; p.L1181S; 5:31410871-31410871	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2179G>A; p.E727K; 5:31472125-31472125	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.1910C>T; p.P637L; 5:31486495-31486495	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3610G>A; p.D1204N; 5:31410803-31410803	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2516C>T; p.T839M; 5:31464294-31464294	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.905C>G; p.S302C; 5:31521165-31521165	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2333G>A; p.R778H; 5:31467972-31467972	liver	carcinoma	Substitution - Missense
c.1404T>G; p.P468P; 5:31511063-31511063	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3765T>C; p.N1255N; 5:31409145-31409145	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2333G>A; p.R778H; 5:31467972-31467972	liver	carcinoma	Substitution - Missense
c.1177G>A; p.E393K; 5:31515101-31515101	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2790A>G; p.R930R; 5:31449312-31449312	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.3462G>A; p.M1154I; 5:31421335-31421335	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2552G>T; p.G851V; 5:31464258-31464258	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3849G>C; p.L1283L; 5:31409061-31409061	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.3038C>A; p.A1013E; 5:31435769-31435769	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3038C>A; p.A1013E; 5:31435769-31435769	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3038C>A; p.A1013E; 5:31435769-31435769	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.833A>G; p.H278R; 5:31526100-31526100	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.3887G>A; p.R1296Q; 5:31406913-31406913	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3875C>T; p.P1292L; 5:31406925-31406925	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2276G>A; p.R759H; 5:31468029-31468029	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2276G>A; p.R759H; 5:31468029-31468029	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.911A>C; p.E304A; 5:31521159-31521159	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3823G>T; p.E1275*; 5:31409087-31409087	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1953C>T; p.F651F; 5:31484924-31484924	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.612C>G; p.F204L; 5:31526321-31526321	ovary	other; neoplasm	Substitution - Missense
c.167C>A; p.P56Q; 5:31526766-31526766	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation