lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2909
Symbol	ARHGAP35
Synonymous	GRF-1\|GRLF1\|P190-A\|P190A\|p190ARhoGAP\|p190RhoGAP
Full name	Rho GTPase activating protein 35
Gene description	glucocorticoid receptor DNA binding factor 1\|glucocorticoid receptor DNA-binding factor 1\|glucocorticoid receptor repression factor 1\|rho GAP p190A\|rho GTPase-activating protein 35
Cytoband	19q13.3
Gene type	protein-coding
Synonymous	MIM:605277; HGNC:HGNC:4591; Ensembl:ENSG00000160007; HPRD:05592; Vega:OTTHUMG00000183438

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.456C>T; p.D152D; 19:46919131-46919131	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3775A>T; p.K1259*; 19:46937357-46937357	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.1384G>C; p.E462Q; 19:46920059-46920059	urinary_tract; bladder	carcinoma	Substitution - Missense
c.168C>T; p.S56S; 19:46918843-46918843	skin	malignant_melanoma	Substitution - coding silent
c.2620C>T; p.L874F; 19:46921295-46921295	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3433C>T; p.R1145*; 19:46922108-46922108	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.3433C>T; p.R1145*; 19:46922108-46922108	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.3433C>T; p.R1145*; 19:46922108-46922108	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2815A>C; p.K939Q; 19:46921490-46921490	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2496G>A; p.R832R; 19:46921171-46921171	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1612G>A; p.A538T; 19:46920287-46920287	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1213G>A; p.D405N; 19:46919888-46919888	liver	carcinoma	Substitution - Missense
c.2720_2721insG; p.E909fs*8; 19:46921395-46921396	lung	carcinoma; squamous_cell_carcinoma	Insertion - Frameshift
c.4017C>T; p.I1339I; 19:46989656-46989656	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.151C>T; p.H51Y; 19:46918826-46918826	NS	NS	Substitution - Missense
c.4001C>G; p.P1334R; 19:46989640-46989640	ovary	other; neoplasm	Substitution - Missense
c.2502A>T; p.E834D; 19:46921177-46921177	skin	malignant_melanoma	Substitution - Missense
c.3949G>A; p.V1317M; 19:46989588-46989588	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1686C>A; p.C562*; 19:46920361-46920361	skin	malignant_melanoma	Substitution - Nonsense
c.506G>A; p.G169D; 19:46919181-46919181	urinary_tract; bladder	carcinoma	Substitution - Missense
c.579G>T; p.K193N; 19:46919254-46919254	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2597C>A; p.S866Y; 19:46921272-46921272	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2597C>A; p.S866Y; 19:46921272-46921272	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1467_1468GG>AA; p.E490K; 19:46920142-46920143	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1585C>T; p.R529*; 19:46920260-46920260	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.4335C>T; p.P1445P; 19:47000523-47000523	pancreas	carcinoma	Substitution - coding silent
c.197G>A; p.R66Q; 19:46918872-46918872	kidney	other; neoplasm	Substitution - Missense
c.720C>G; p.F240L; 19:46919395-46919395	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2740G>T; p.E914*; 19:46921415-46921415	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.321T>C; p.P107P; 19:46918996-46918996	pancreas	carcinoma	Substitution - coding silent
c.3778C>G; p.P1260A; 19:46937360-46937360	urinary_tract; bladder	carcinoma	Substitution - Missense
c.31A>T; p.I11F; 19:46918706-46918706	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1188C>T; p.N396N; 19:46919863-46919863	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.3499C>T; p.R1167W; 19:46922174-46922174	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.387A>C; p.E129D; 19:46919062-46919062	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2461T>G; p.L821V; 19:46921136-46921136	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3886C>T; p.Q1296*; 19:46988048-46988048	oesophagus	carcinoma	Substitution - Nonsense
c.135G>A; p.P45P; 19:46918810-46918810	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1471G>C; p.E491Q; 19:46920146-46920146	urinary_tract; bladder	carcinoma	Substitution - Missense
c.3740T>G; p.F1247C; 19:46937322-46937322	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3422G>A; p.S1141N; 19:46922097-46922097	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3514C>T; p.R1172W; 19:46922189-46922189	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1997A>G; p.N666S; 19:46920672-46920672	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.130C>T; p.R44C; 19:46918805-46918805	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3440G>A; p.R1147H; 19:46922115-46922115	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.4295G>T; p.C1432F; 19:47000483-47000483	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.4476G>T; p.Q1492H; 19:47000664-47000664	thyroid	other; neoplasm	Substitution - Missense
c.638C>T; p.A213V; 19:46919313-46919313	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.840G>T; p.L280L; 19:46919515-46919515	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3506C>A; p.A1169D; 19:46922181-46922181	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.325C>T; p.R109*; 19:46919000-46919000	skin	malignant_melanoma	Substitution - Nonsense
c.325C>T; p.R109*; 19:46919000-46919000	skin	malignant_melanoma	Substitution - Nonsense
c.3304G>A; p.E1102K; 19:46921979-46921979	skin	malignant_melanoma	Substitution - Missense
c.3379T>G; p.S1127A; 19:46922054-46922054	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1111G>T; p.E371*; 19:46919786-46919786	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.6G>T; p.M2I; 19:46918681-46918681	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2072A>C; p.N691T; 19:46920747-46920747	skin	malignant_melanoma	Substitution - Missense
c.4037-1G>T; p.?; 19:46999303-46999303	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Unknown
c.131G>A; p.R44H; 19:46918806-46918806	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2084A>G; p.H695R; 19:46920759-46920759	pancreas	carcinoma	Substitution - Missense
c.2910C>T; p.S970S; 19:46921585-46921585	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1297C>T; p.R433*; 19:46919972-46919972	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1297C>T; p.R433*; 19:46919972-46919972	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1297C>T; p.R433*; 19:46919972-46919972	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1645C>G; p.H549D; 19:46920320-46920320	urinary_tract; bladder	carcinoma	Substitution - Missense
c.609C>T; p.D203D; 19:46919284-46919284	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3905-3C>G; p.?; 19:46989541-46989541	skin; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.126C>T; p.F42F; 19:46918801-46918801	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1943T>C; p.V648A; 19:46920618-46920618	skin	malignant_melanoma	Substitution - Missense
c.987G>T; p.K329N; 19:46919662-46919662	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.3331A>G; p.S1111G; 19:46922006-46922006	oesophagus	carcinoma	Substitution - Missense
c.1702G>A; p.A568T; 19:46920377-46920377	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2344C>T; p.L782L; 19:46921019-46921019	kidney	other; neoplasm	Substitution - coding silent
c.759G>A; p.K253K; 19:46919434-46919434	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.347A>G; p.Y116C; 19:46919022-46919022	pancreas	carcinoma	Substitution - Missense
c.2744T>A; p.I915N; 19:46921419-46921419	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3430G>T; p.E1144*; 19:46922105-46922105	pancreas	carcinoma	Substitution - Nonsense
c.3098T>G; p.L1033R; 19:46921773-46921773	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3098T>G; p.L1033R; 19:46921773-46921773	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3098T>G; p.L1033R; 19:46921773-46921773	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3541G>T; p.D1181Y; 19:46922216-46922216	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.4354C>T; p.P1452S; 19:47000542-47000542	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3541G>T; p.D1181Y; 19:46922216-46922216	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4330delC; p.G1446fs*>54; 19:47000518-47000518	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.4330delC; p.G1446fs*>54; 19:47000518-47000518	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2549G>A; p.R850Q; 19:46921224-46921224	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2615C>T; p.A872V; 19:46921290-46921290	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.4002G>A; p.P1334P; 19:46989641-46989641	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2197C>G; p.L733V; 19:46920872-46920872	ovary	other; neoplasm	Substitution - Missense
c.2304C>G; p.V768V; 19:46920979-46920979	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1102A>C; p.K368Q; 19:46919777-46919777	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.3682-1G>A; p.?; 19:46937263-46937263	breast	carcinoma	Unknown
c.3621C>T; p.Y1207Y; 19:46922296-46922296	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.4338C>T; p.G1446G; 19:47000526-47000526	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.4472C>T; p.S1491F; 19:47000660-47000660	skin	malignant_melanoma	Substitution - Missense
c.2597C>T; p.S866F; 19:46921272-46921272	skin	malignant_melanoma	Substitution - Missense
c.2089C>T; p.P697S; 19:46920764-46920764	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1896G>C; p.M632I; 19:46920571-46920571	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1701C>T; p.D567D; 19:46920376-46920376	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.979C>T; p.R327C; 19:46919654-46919654	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2632C>A; p.Q878K; 19:46921307-46921307	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.641A>C; p.H214P; 19:46919316-46919316	liver	carcinoma	Substitution - Missense
c.641A>C; p.H214P; 19:46919316-46919316	liver	carcinoma	Substitution - Missense
c.641A>C; p.H214P; 19:46919316-46919316	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3528C>T; p.S1176S; 19:46922203-46922203	pancreas	carcinoma	Substitution - coding silent
c.1579G>A; p.E527K; 19:46920254-46920254	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1579G>A; p.E527K; 19:46920254-46920254	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.2177G>A; p.S726N; 19:46920852-46920852	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.504G>A; p.R168R; 19:46919179-46919179	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.318A>T; p.Q106H; 19:46918993-46918993	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2199C>T; p.L733L; 19:46920874-46920874	breast	carcinoma	Substitution - coding silent
c.3808G>T; p.E1270*; 19:46937390-46937390	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.4062G>A; p.L1354L; 19:46999329-46999329	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2748C>T; p.D916D; 19:46921423-46921423	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1742C>T; p.P581L; 19:46920417-46920417	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2169A>C; p.Q723H; 19:46920844-46920844	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.3380C>A; p.S1127Y; 19:46922055-46922055	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.4121A>G; p.Y1374C; 19:46999388-46999388	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.628A>G; p.I210V; 19:46919303-46919303	pancreas	carcinoma	Substitution - Missense
c.4375G>A; p.V1459I; 19:47000563-47000563	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2825T>C; p.V942A; 19:46921500-46921500	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.4486G>A; p.E1496K; 19:47000674-47000674	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1335C>T; p.F445F; 19:46920010-46920010	skin	malignant_melanoma	Substitution - coding silent
c.3997G>T; p.V1333F; 19:46989636-46989636	pancreas	carcinoma	Substitution - Missense
c.3647G>C; p.R1216T; 19:46922322-46922322	kidney	other; neoplasm	Substitution - Missense
c.923A>G; p.Y308C; 19:46919598-46919598	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.3499C>A; p.R1167R; 19:46922174-46922174	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2989C>T; p.R997*; 19:46921664-46921664	breast	carcinoma	Substitution - Nonsense
c.2989C>T; p.R997*; 19:46921664-46921664	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2989C>T; p.R997*; 19:46921664-46921664	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.4070T>A; p.L1357H; 19:46999337-46999337	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1159C>T; p.P387S; 19:46919834-46919834	skin	malignant_melanoma	Substitution - Missense
c.3391G>A; p.G1131R; 19:46922066-46922066	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.738C>G; p.L246L; 19:46919413-46919413	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.4000C>T; p.P1334S; 19:46989639-46989639	skin	malignant_melanoma	Substitution - Missense
c.1305G>A; p.A435A; 19:46919980-46919980	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1331C>T; p.P444L; 19:46920006-46920006	skin	malignant_melanoma	Substitution - Missense
c.4242C>T; p.A1414A; 19:47000430-47000430	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1692T>C; p.A564A; 19:46920367-46920367	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1619G>A; p.R540H; 19:46920294-46920294	central_nervous_system; brain	glioma	Substitution - Missense
c.4299_4301delCTT; p.F1436delF; 19:47000487-47000489	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - In frame
c.2194T>G; p.F732V; 19:46920869-46920869	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3641G>A; p.R1214Q; 19:46922316-46922316	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1559T>C; p.I520T; 19:46920234-46920234	soft_tissue; striated_muscle	rhabdomyosarcoma	Substitution - Missense
c.1197C>T; p.N399N; 19:46919872-46919872	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.4204C>A; p.P1402T; 19:47000392-47000392	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2540G>C; p.R847T; 19:46921215-46921215	urinary_tract; bladder	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation