| Gene ID | 2879 |
| Symbol | GPX4 |
| Synonymous | GPx-4|GSHPx-4|MCSP|PHGPx|snGPx|snPHGPx |
| Full name | glutathione peroxidase 4 |
| Gene description | phospholipid hydroperoxidase|phospholipid hydroperoxide glutathione peroxidase, mitochondrial|sperm nucleus glutathione peroxidase |
| Cytoband | 19p13.3 |
| Gene type | protein-coding |
| Synonymous | MIM:138322; HGNC:HGNC:4556; Ensembl:ENSG00000167468; HPRD:11819; Vega:OTTHUMG00000181874 |
Mutation (CDS; AA; Chr) | Site | Histology | Mutation Type |
|---|---|---|---|
c.95G>A; p.R32Q; 19:1105196-1105196 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.95G>A; p.R32Q; 19:1105196-1105196 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.243T>C; p.T81T; 19:1105429-1105429 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.402C>T; p.C134C; 19:1105735-1105735 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.138C>A; p.A46A; 19:1105239-1105239 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - coding silent |
c.157A>G; p.M53V; 19:1105258-1105258 |
bone | Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour | Substitution - Missense |
c.22C>T; p.R8C; 19:1104065-1104065 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.115C>T; p.R39C; 19:1105216-1105216 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.191G>A; p.C64Y; 19:1105377-1105377 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.411G>T; p.G137G; 19:1105744-1105744 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - coding silent |
c.434A>G; p.K145R; 19:1105767-1105767 |
oesophagus; middle_third | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.426G>A; p.P142P; 19:1105759-1105759 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.313T>C; p.F105L; 19:1105499-1105499 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.155A>C; p.H52P; 19:1105256-1105256 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.358G>A; p.A120T; 19:1105691-1105691 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.541_542GG>AA; p.G181K; 19:1106439-1106440 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.418G>A; p.A140T; 19:1105751-1105751 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.510C>T; p.I170I; 19:1106408-1106408 |
prostate | carcinoma; adenocarcinoma | Substitution - coding silent |
c.510C>T; p.I170I; 19:1106408-1106408 |
breast | carcinoma | Substitution - coding silent |
c.476+4C>G; p.?; 19:1105813-1105813 |
oesophagus; lower_third | carcinoma; squamous_cell_carcinoma | Unknown |
c.495C>T; p.F165F; 19:1106260-1106260 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.522C>T; p.G174G; 19:1106420-1106420 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - coding silent |
c.521G>C; p.G174A; 19:1106419-1106419 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |