lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	286319
Symbol	TUSC1
Synonymous	TSG-9\|TSG9
Full name	tumor suppressor candidate 1
Gene description	tumor suppressor candidate gene 1 protein
Cytoband	9p21.2
Gene type	protein-coding
Synonymous	MIM:610529; HGNC:HGNC:31010; Ensembl:ENSG00000198680; HPRD:18247; Vega:OTTHUMG00000159591

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.424G>T; p.A142S; 9:25677898-25677898	liver	carcinoma	Substitution - Missense
c.614C>T; p.S205L; 9:25677708-25677708	liver	carcinoma	Substitution - Missense
c.614C>T; p.S205L; 9:25677708-25677708	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.214C>G; p.H72D; 9:25678108-25678108	liver	carcinoma	Substitution - Missense
c.214C>G; p.H72D; 9:25678108-25678108	liver	carcinoma	Substitution - Missense
c.198C>G; p.A66A; 9:25678124-25678124	thyroid	other; neoplasm	Substitution - coding silent
c.367A>G; p.N123D; 9:25677955-25677955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.367A>G; p.N123D; 9:25677955-25677955	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.367A>G; p.N123D; 9:25677955-25677955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.367A>G; p.N123D; 9:25677955-25677955	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.367A>G; p.N123D; 9:25677955-25677955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.367A>G; p.N123D; 9:25677955-25677955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.367A>G; p.N123D; 9:25677955-25677955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.367A>G; p.N123D; 9:25677955-25677955	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.367A>G; p.N123D; 9:25677955-25677955	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.142_143insGCG; p.G47_V48insG; 9:25678179-25678180	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Insertion - In frame
c.509G>A; p.R170Q; 9:25677813-25677813	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.188A>C; p.E63A; 9:25678134-25678134	thyroid	carcinoma; medullary_carcinoma	Substitution - Missense
c.220G>T; p.E74*; 9:25678102-25678102	prostate	carcinoma; adenocarcinoma	Substitution - Nonsense
c.605C>T; p.S202F; 9:25677717-25677717	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.510G>A; p.R170R; 9:25677812-25677812	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.380C>T; p.A127V; 9:25677942-25677942	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.440G>T; p.R147L; 9:25677882-25677882	liver	carcinoma	Substitution - Missense
c.387A>G; p.A129A; 9:25677935-25677935	thyroid	other; neoplasm	Substitution - coding silent
c.387A>G; p.A129A; 9:25677935-25677935	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.387A>G; p.A129A; 9:25677935-25677935	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.387A>G; p.A129A; 9:25677935-25677935	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.387A>G; p.A129A; 9:25677935-25677935	thyroid	other; neoplasm	Substitution - coding silent
c.387A>G; p.A129A; 9:25677935-25677935	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.387A>G; p.A129A; 9:25677935-25677935	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.622T>G; p.S208A; 9:25677700-25677700	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.622T>G; p.S208A; 9:25677700-25677700	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.622T>G; p.S208A; 9:25677700-25677700	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.622T>G; p.S208A; 9:25677700-25677700	thyroid	other; neoplasm	Substitution - Missense
c.622T>G; p.S208A; 9:25677700-25677700	thyroid	other; neoplasm	Substitution - Missense
c.335G>A; p.R112H; 9:25677987-25677987	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation