lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	285
Symbol	ANGPT2
Synonymous	AGPT2\|ANG2
Full name	angiopoietin 2
Gene description	ANG-2\|Tie2-ligand\|angiopoietin-2\|angiopoietin-2B\|angiopoietin-2a
Cytoband	8p23.1
Gene type	protein-coding
Synonymous	MIM:601922; HGNC:HGNC:485; Ensembl:ENSG00000091879; HPRD:03563; Vega:OTTHUMG00000090365

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1063C>G; p.L355V; 8:6513814-6513814	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.701T>A; p.I234K; 8:6521276-6521276	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.808G>A; p.D270N; 8:6519986-6519986	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.272C>G; p.T91S; 8:6562663-6562663	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.69G>A; p.R23R; 8:6562866-6562866	skin	malignant_melanoma	Substitution - coding silent
c.794C>G; p.S265*; 8:6521183-6521183	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.464G>A; p.R155K; 8:6527657-6527657	breast	carcinoma; HER-positive_carcinoma	Substitution - Missense
c.442C>T; p.Q148*; 8:6532334-6532334	salivary_gland	carcinoma; adenoid_cystic_carcinoma	Substitution - Nonsense
c.469G>A; p.E157K; 8:6527652-6527652	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.88G>C; p.G30R; 8:6562847-6562847	breast	carcinoma	Substitution - Missense
c.496T>G; p.S166A; 8:6527625-6527625	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.594G>A; p.M198I; 8:6521383-6521383	skin	malignant_melanoma	Substitution - Missense
c.914C>G; p.S305C; 8:6519880-6519880	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1126A>C; p.K376Q; 8:6513751-6513751	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.897G>A; p.T299T; 8:6519897-6519897	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.442C>A; p.Q148K; 8:6532334-6532334	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1072G>C; p.E358Q; 8:6513805-6513805	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1481C>T; p.A494V; 8:6503111-6503111	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1251C>T; p.S417S; 8:6509011-6509011	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.514A>C; p.K172Q; 8:6527607-6527607	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.498G>A; p.S166S; 8:6527623-6527623	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.498G>A; p.S166S; 8:6527623-6527623	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.799+8T>A; p.?; 8:6521170-6521170	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.907C>A; p.P303T; 8:6519887-6519887	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1041T>C; p.G347G; 8:6513836-6513836	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.49G>A; p.A17T; 8:6562886-6562886	liver	carcinoma	Substitution - Missense
c.656T>A; p.L219*; 8:6521321-6521321	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.647T>C; p.L216P; 8:6521330-6521330	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.49G>A; p.A17T; 8:6562886-6562886	liver	carcinoma	Substitution - Missense
c.826G>A; p.E276K; 8:6519968-6519968	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.993C>T; p.G331G; 8:6514716-6514716	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1247T>C; p.I416T; 8:6509015-6509015	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.408G>T; p.A136A; 8:6532368-6532368	thyroid	other; neoplasm	Substitution - coding silent
c.978G>A; p.Q326Q; 8:6514731-6514731	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.695A>G; p.K232R; 8:6521282-6521282	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.328G>A; p.V110I; 8:6532448-6532448	liver	carcinoma	Substitution - Missense
c.700_701insA; p.I234fs*8; 8:6521276-6521277	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.700_701insA; p.I234fs*8; 8:6521276-6521277	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.731T>C; p.L244P; 8:6521246-6521246	breast	carcinoma	Substitution - Missense
c.490T>C; p.S164P; 8:6527631-6527631	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1037T>G; p.F346C; 8:6513840-6513840	skin	malignant_melanoma	Substitution - Missense
c.93G>T; p.K31N; 8:6562842-6562842	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.93G>T; p.K31N; 8:6562842-6562842	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.205G>A; p.A69T; 8:6562730-6562730	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.516A>G; p.K172K; 8:6527605-6527605	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.516A>G; p.K172K; 8:6527605-6527605	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.516A>G; p.K172K; 8:6527605-6527605	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.733C>T; p.Q245*; 8:6521244-6521244	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.758A>T; p.E253V; 8:6521219-6521219	skin	malignant_melanoma	Substitution - Missense
c.1103G>A; p.R368H; 8:6513774-6513774	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.204C>G; p.D68E; 8:6562731-6562731	ovary	other; neoplasm	Substitution - Missense
c.1103G>A; p.R368H; 8:6513774-6513774	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.642T>A; p.D214E; 8:6521335-6521335	prostate	adenoma	Substitution - Missense
c.212T>C; p.L71P; 8:6562723-6562723	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.693A>T; p.E231D; 8:6521284-6521284	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.700delA; p.I234fs*1; 8:6521277-6521277	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.700delA; p.I234fs*1; 8:6521277-6521277	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.700delA; p.I234fs*1; 8:6521277-6521277	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.700delA; p.I234fs*1; 8:6521277-6521277	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.408G>C; p.A136A; 8:6532368-6532368	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.408G>C; p.A136A; 8:6532368-6532368	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.700delA; p.I234fs*1; 8:6521277-6521277	pancreas	carcinoma; acinar_carcinoma	Deletion - Frameshift
c.1382C>A; p.P461Q; 8:6503210-6503210	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.714G>T; p.T238T; 8:6521263-6521263	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1021G>T; p.E341*; 8:6514688-6514688	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.636G>A; p.E212E; 8:6521341-6521341	skin	malignant_melanoma	Substitution - coding silent
c.161G>A; p.R54H; 8:6562774-6562774	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.161G>A; p.R54H; 8:6562774-6562774	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.927C>A; p.I309I; 8:6519867-6519867	liver	carcinoma	Substitution - coding silent
c.927C>A; p.I309I; 8:6519867-6519867	ovary	other; neoplasm	Substitution - coding silent
c.1348T>C; p.C450R; 8:6503244-6503244	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1068A>G; p.G356G; 8:6513809-6513809	breast	carcinoma	Substitution - coding silent
c.1327G>A; p.G443R; 8:6508935-6508935	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.882G>A; p.T294T; 8:6519912-6519912	thyroid	other; neoplasm	Substitution - coding silent
c.1370G>A; p.G457E; 8:6503222-6503222	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.636G>T; p.E212D; 8:6521341-6521341	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.793T>G; p.S265A; 8:6521184-6521184	prostate	adenoma	Substitution - Missense
c.1300A>C; p.I434L; 8:6508962-6508962	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.609C>G; p.I203M; 8:6521368-6521368	skin	malignant_melanoma	Substitution - Missense
c.1311T>C; p.C437C; 8:6508951-6508951	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.979C>T; p.R327*; 8:6514730-6514730	oesophagus	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1230C>A; p.A410A; 8:6509032-6509032	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.971T>A; p.I324N; 8:6514738-6514738	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.48C>A; p.A16A; 8:6562887-6562887	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.714G>A; p.T238T; 8:6521263-6521263	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1217T>A; p.L406H; 8:6509045-6509045	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.428C>A; p.T143N; 8:6532348-6532348	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1411G>A; p.G471S; 8:6503181-6503181	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1102C>T; p.R368C; 8:6513775-6513775	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1102C>T; p.R368C; 8:6513775-6513775	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.677T>A; p.I226N; 8:6521300-6521300	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.536G>C; p.S179T; 8:6527585-6527585	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.572_573insT; p.E192fs*37; 8:6521404-6521405	skin	malignant_melanoma	Insertion - Frameshift
c.1241G>A; p.S414N; 8:6509021-6509021	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.996C>T; p.S332S; 8:6514713-6514713	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1369G>A; p.G457R; 8:6503223-6503223	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1369G>A; p.G457R; 8:6503223-6503223	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.960C>G; p.G320G; 8:6514749-6514749	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.813C>A; p.P271P; 8:6519981-6519981	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.207G>A; p.A69A; 8:6562728-6562728	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.389A>T; p.N130I; 8:6532387-6532387	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.119C>T; p.S40F; 8:6562816-6562816	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.318G>T; p.K106N; 8:6532458-6532458	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1201A>C; p.I401L; 8:6509061-6509061	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.9G>T; p.Q3H; 8:6562926-6562926	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1159T>C; p.Y387H; 8:6513718-6513718	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.418C>T; p.R140W; 8:6532358-6532358	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.692delA; p.I234fs*1; 8:6521285-6521285	large_intestine; colon	carcinoma	Deletion - Frameshift
c.1282G>A; p.G428R; 8:6508980-6508980	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation