lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2829
Symbol	XCR1
Synonymous	CCXCR1\|GPR5
Full name	chemokine (C motif) receptor 1
Gene description	G protein-coupled receptor 5\|G-protein coupled receptor 5\|XC chemokine receptor 1\|chemokine (C motif) XC receptor 1\|chemokine XC receptor 1\|lymphotactin receptor
Cytoband	3p21.3
Gene type	protein-coding
Synonymous	MIM:600552; HGNC:HGNC:1625; HPRD:02774

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.213C>T; p.L71L; 3:46021735-46021735	skin	malignant_melanoma	Substitution - coding silent
c.770G>A; p.R257Q; 3:46021178-46021178	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.907C>T; p.R303W; 3:46021041-46021041	liver	carcinoma	Substitution - Missense
c.907C>T; p.R303W; 3:46021041-46021041	liver	carcinoma	Substitution - Missense
c.754C>T; p.R252W; 3:46021194-46021194	skin	malignant_melanoma	Substitution - Missense
c.754C>T; p.R252W; 3:46021194-46021194	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.582C>T; p.F194F; 3:46021366-46021366	skin	malignant_melanoma	Substitution - coding silent
c.720C>T; p.P240P; 3:46021228-46021228	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.423_424insC; p.T142fs*35; 3:46021524-46021525	skin	malignant_melanoma	Insertion - Frameshift
c.479C>T; p.S160F; 3:46021469-46021469	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.466G>A; p.A156T; 3:46021482-46021482	pancreas	carcinoma; adenocarcinoma	Substitution - Missense
c.518C>T; p.S173L; 3:46021430-46021430	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.805C>A; p.L269M; 3:46021143-46021143	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.664C>T; p.R222C; 3:46021284-46021284	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.40delT; p.Y14fs*33; 3:46021908-46021908	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.40delT; p.Y14fs*33; 3:46021908-46021908	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.40delT; p.Y14fs*33; 3:46021908-46021908	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.40delT; p.Y14fs*33; 3:46021908-46021908	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.669G>A; p.T223T; 3:46021279-46021279	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.419T>C; p.V140A; 3:46021529-46021529	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.975C>T; p.F325F; 3:46020973-46020973	skin	malignant_melanoma	Substitution - coding silent
c.993C>T; p.S331S; 3:46020955-46020955	skin	malignant_melanoma	Substitution - coding silent
c.702C>T; p.Y234Y; 3:46021246-46021246	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.624C>A; p.I208I; 3:46021324-46021324	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.615C>T; p.Y205Y; 3:46021333-46021333	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_B_cell_leukaemia	Substitution - coding silent
c.439G>A; p.V147M; 3:46021509-46021509	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3G>A; p.M1I; 3:46021945-46021945	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.241G>A; p.A81T; 3:46021707-46021707	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.558C>T; p.S186S; 3:46021390-46021390	skin	malignant_melanoma	Substitution - coding silent
c.558C>T; p.S186S; 3:46021390-46021390	skin	malignant_melanoma	Substitution - coding silent
c.300C>T; p.F100F; 3:46021648-46021648	skin	malignant_melanoma	Substitution - coding silent
c.121G>A; p.V41M; 3:46021827-46021827	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.273C>T; p.Y91Y; 3:46021675-46021675	breast	carcinoma	Substitution - coding silent
c.281G>C; p.G94A; 3:46021667-46021667	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.985G>A; p.G329S; 3:46020963-46020963	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.639C>T; p.F213F; 3:46021309-46021309	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.97G>T; p.A33S; 3:46021851-46021851	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.331A>C; p.I111L; 3:46021617-46021617	prostate	carcinoma	Substitution - Missense
c.417C>T; p.R139R; 3:46021531-46021531	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.534C>T; p.S178S; 3:46021414-46021414	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.489C>T; p.L163L; 3:46021459-46021459	skin	malignant_melanoma	Substitution - coding silent
c.223C>T; p.L75F; 3:46021725-46021725	skin	malignant_melanoma	Substitution - Missense
c.24G>C; p.E8D; 3:46021924-46021924	breast	carcinoma	Substitution - Missense
c.97G>A; p.A33T; 3:46021851-46021851	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.97G>A; p.A33T; 3:46021851-46021851	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.97G>A; p.A33T; 3:46021851-46021851	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.97G>A; p.A33T; 3:46021851-46021851	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.465A>G; p.V155V; 3:46021483-46021483	oesophagus	carcinoma	Substitution - coding silent
c.409A>C; p.T137P; 3:46021539-46021539	breast	carcinoma	Substitution - Missense
c.833C>T; p.S278F; 3:46021115-46021115	skin	malignant_melanoma	Substitution - Missense
c.580T>A; p.F194I; 3:46021368-46021368	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.597G>A; p.G199G; 3:46021351-46021351	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.668C>T; p.T223M; 3:46021280-46021280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.485T>C; p.I162T; 3:46021463-46021463	NS	malignant_melanoma	Substitution - Missense
c.185T>C; p.L62P; 3:46021763-46021763	skin	malignant_melanoma	Substitution - Missense
c.94C>A; p.L32I; 3:46021854-46021854	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.594G>A; p.L198L; 3:46021354-46021354	skin	malignant_melanoma	Substitution - coding silent
c.747G>A; p.T249T; 3:46021201-46021201	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.594G>A; p.L198L; 3:46021354-46021354	skin	malignant_melanoma	Substitution - coding silent
c.755G>A; p.R252Q; 3:46021193-46021193	pituitary; craniopharyngeal_duct	craniopharyngioma; adamantinomatous	Substitution - Missense
c.240C>T; p.F80F; 3:46021708-46021708	NS	NS	Substitution - coding silent
c.551T>C; p.L184P; 3:46021397-46021397	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.599T>G; p.I200S; 3:46021349-46021349	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.431G>A; p.R144H; 3:46021517-46021517	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.200A>G; p.N67S; 3:46021748-46021748	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.427C>T; p.L143F; 3:46021521-46021521	skin	malignant_melanoma	Substitution - Missense
c.872G>A; p.G291E; 3:46021076-46021076	skin	malignant_melanoma	Substitution - Missense
c.665G>A; p.R222H; 3:46021283-46021283	pancreas	carcinoma	Substitution - Missense
c.665G>A; p.R222H; 3:46021283-46021283	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.211C>A; p.L71I; 3:46021737-46021737	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.665G>A; p.R222H; 3:46021283-46021283	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.171G>A; p.V57V; 3:46021777-46021777	skin	malignant_melanoma	Substitution - coding silent
c.647G>A; p.R216H; 3:46021301-46021301	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.202A>G; p.I68V; 3:46021746-46021746	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.921C>G; p.F307L; 3:46021027-46021027	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.496A>G; p.I166V; 3:46021452-46021452	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.496A>G; p.I166V; 3:46021452-46021452	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.378C>T; p.H126H; 3:46021570-46021570	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.63G>A; p.P21P; 3:46021885-46021885	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.904C>T; p.L302F; 3:46021044-46021044	skin	malignant_melanoma	Substitution - Missense
c.904C>T; p.L302F; 3:46021044-46021044	skin	malignant_melanoma	Substitution - Missense
c.690C>T; p.I230I; 3:46021258-46021258	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.614A>G; p.Y205C; 3:46021334-46021334	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.245G>A; p.C82Y; 3:46021703-46021703	breast	carcinoma	Substitution - Missense
c.422C>T; p.P141L; 3:46021526-46021526	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.139G>C; p.V47L; 3:46021809-46021809	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.540C>A; p.L180L; 3:46021408-46021408	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.416G>A; p.R139H; 3:46021532-46021532	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.416G>A; p.R139H; 3:46021532-46021532	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.416G>A; p.R139H; 3:46021532-46021532	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.778G>A; p.E260K; 3:46021170-46021170	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.333C>T; p.I111I; 3:46021615-46021615	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.697G>T; p.A233S; 3:46021251-46021251	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.697G>T; p.A233S; 3:46021251-46021251	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.697G>T; p.A233S; 3:46021251-46021251	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.697G>T; p.A233S; 3:46021251-46021251	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.697G>T; p.A233S; 3:46021251-46021251	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.697G>T; p.A233S; 3:46021251-46021251	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.950C>T; p.S317L; 3:46020998-46020998	skin	malignant_melanoma	Substitution - Missense
c.193C>T; p.L65F; 3:46021755-46021755	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.950C>T; p.S317L; 3:46020998-46020998	skin	malignant_melanoma	Substitution - Missense
c.535G>A; p.E179K; 3:46021413-46021413	skin	malignant_melanoma	Substitution - Missense
c.535G>A; p.E179K; 3:46021413-46021413	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.285G>T; p.W95C; 3:46021663-46021663	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.380G>A; p.R127H; 3:46021568-46021568	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.542C>T; p.T181M; 3:46021406-46021406	breast	carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation