lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	2769
Symbol	GNA15
Synonymous	GNA16
Full name	guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Gene description	G-protein subunit alpha-15\|G-protein subunit alpha-16\|epididymis tissue protein Li 17E\|g alpha-15\|g alpha-16\|guanine nucleotide-binding protein subunit alpha-15\|guanine nucleotide-binding protein subunit alpha-16
Cytoband	19p13.3
Gene type	protein-coding
Synonymous	MIM:139314; HGNC:HGNC:4383; Ensembl:ENSG00000060558; HPRD:00760; Vega:OTTHUMG00000180637

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.595G>A; p.V199M; 19:3151816-3151816	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.595G>A; p.V199M; 19:3151816-3151816	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.595G>A; p.V199M; 19:3151816-3151816	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.485+1G>T; p.?; 19:3150286-3150286	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.875C>T; p.A292V; 19:3157858-3157858	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.212C>T; p.S71L; 19:3148657-3148657	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.580G>A; p.E194K; 19:3151801-3151801	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.850G>A; p.E284K; 19:3157833-3157833	skin; extremity	malignant_melanoma	Substitution - Missense
c.557G>A; p.R186H; 19:3151778-3151778	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.557G>A; p.R186H; 19:3151778-3151778	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.557G>A; p.R186H; 19:3151778-3151778	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.557G>A; p.R186H; 19:3151778-3151778	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1096C>T; p.R366C; 19:3162990-3162990	skin; upper_back	malignant_melanoma	Substitution - Missense
c.1096C>T; p.R366C; 19:3162990-3162990	skin	malignant_melanoma	Substitution - Missense
c.1058G>A; p.R353H; 19:3162952-3162952	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.398C>T; p.A133V; 19:3150198-3150198	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.399G>A; p.A133A; 19:3150199-3150199	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.588C>T; p.C196C; 19:3151809-3151809	skin	malignant_melanoma	Substitution - coding silent
c.1009C>T; p.R337*; 19:3162903-3162903	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.434G>A; p.R145Q; 19:3150234-3150234	pancreas	carcinoma	Substitution - Missense
c.282C>G; p.I94M; 19:3148727-3148727	pancreas	carcinoma	Substitution - Missense
c.448C>T; p.R150C; 19:3150248-3150248	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.448C>T; p.R150C; 19:3150248-3150248	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.950C>T; p.T317M; 19:3162844-3162844	central_nervous_system; brainstem	glioma; oligoastrocytoma_Grade_III	Substitution - Missense
c.658_659AT>CC; p.I220P; 19:3155866-3155867	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.417G>A; p.W139*; 19:3150217-3150217	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.479C>T; p.A160V; 19:3150279-3150279	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.183G>A; p.Q61Q; 19:3148628-3148628	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.525C>T; p.Y175Y; 19:3151746-3151746	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.748C>T; p.R250C; 19:3157731-3157731	liver	carcinoma	Substitution - Missense
c.332A>T; p.H111L; 19:3150132-3150132	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1120C>T; p.L374L; 19:3163014-3163014	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.627C>T; p.V209V; 19:3155835-3155835	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.627C>T; p.V209V; 19:3155835-3155835	skin	malignant_melanoma	Substitution - coding silent
c.282C>T; p.I94I; 19:3148727-3148727	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.224G>A; p.R75H; 19:3148669-3148669	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.704T>G; p.L235R; 19:3155912-3155912	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.618C>T; p.I206I; 19:3155826-3155826	skin	malignant_melanoma	Substitution - coding silent
c.618C>T; p.I206I; 19:3155826-3155826	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.859C>T; p.P287S; 19:3157842-3157842	skin	malignant_melanoma	Substitution - Missense
c.618C>T; p.I206I; 19:3155826-3155826	skin	malignant_melanoma	Substitution - coding silent
c.594C>T; p.S198S; 19:3151815-3151815	skin	malignant_melanoma	Substitution - coding silent
c.657G>A; p.W219*; 19:3155865-3155865	skin	malignant_melanoma	Substitution - Nonsense
c.506G>A; p.R169H; 19:3151727-3151727	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.809C>T; p.T270I; 19:3157792-3157792	urinary_tract; bladder	carcinoma	Substitution - Missense
c.63C>A; p.A21A; 19:3136513-3136513	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.567C>G; p.T189T; 19:3151788-3151788	breast	carcinoma	Substitution - coding silent
c.516G>A; p.E172E; 19:3151737-3151737	skin	malignant_melanoma	Substitution - coding silent
c.858C>T; p.I286I; 19:3157841-3157841	skin; head_neck	malignant_melanoma; superficial_spreading	Substitution - coding silent
c.524A>G; p.Y175C; 19:3151745-3151745	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1043_1044delAC; p.Q350fs*>25; 19:3162937-3162938	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.195C>T; p.I65I; 19:3148640-3148640	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.338C>T; p.A113V; 19:3150138-3150138	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.669C>T; p.F223F; 19:3155877-3155877	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.669C>T; p.F223F; 19:3155877-3155877	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.669C>T; p.F223F; 19:3155877-3155877	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - coding silent
c.658A>T; p.I220F; 19:3155866-3155866	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.196C>T; p.H66Y; 19:3148641-3148641	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.761G>A; p.S254N; 19:3157744-3157744	kidney	other; neoplasm	Substitution - Missense
c.32C>T; p.P11L; 19:3136482-3136482	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.32C>T; p.P11L; 19:3136482-3136482	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.320C>T; p.P107L; 19:3148765-3148765	eye; uveal_tract	malignant_melanoma; mixed	Substitution - Missense
c.937C>A; p.L313M; 19:3162831-3162831	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.472G>A; p.D158N; 19:3150272-3150272	skin	malignant_melanoma	Substitution - Missense
c.472G>A; p.D158N; 19:3150272-3150272	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.762C>G; p.S254R; 19:3157745-3157745	kidney	other; neoplasm	Substitution - Missense
c.457G>A; p.E153K; 19:3150257-3150257	skin	malignant_melanoma	Substitution - Missense
c.1017C>T; p.L339L; 19:3162911-3162911	thyroid	other; neoplasm	Substitution - coding silent
c.738C>T; p.N246N; 19:3155946-3155946	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.738C>T; p.N246N; 19:3155946-3155946	skin	malignant_melanoma	Substitution - coding silent
c.901C>T; p.P301S; 19:3162795-3162795	skin	malignant_melanoma	Substitution - Missense
c.144G>C; p.L48F; 19:3136594-3136594	skin	malignant_melanoma	Substitution - Missense
c.849G>A; p.E283E; 19:3157832-3157832	skin	malignant_melanoma	Substitution - coding silent
c.1097G>T; p.R366L; 19:3162991-3162991	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.653A>C; p.K218T; 19:3155861-3155861	skin	malignant_melanoma	Substitution - Missense
c.517G>A; p.E173K; 19:3151738-3151738	skin	malignant_melanoma	Substitution - Missense
c.517G>A; p.E173K; 19:3151738-3151738	skin	malignant_melanoma	Substitution - Missense
c.517G>A; p.E173K; 19:3151738-3151738	skin	malignant_melanoma	Substitution - Missense
c.982G>A; p.E328K; 19:3162876-3162876	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.812C>G; p.S271C; 19:3157795-3157795	liver	carcinoma	Substitution - Missense
c.820C>T; p.L274F; 19:3157803-3157803	skin	malignant_melanoma	Substitution - Missense
c.526G>A; p.V176I; 19:3151747-3151747	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.160G>A; p.G54R; 19:3148605-3148605	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.500T>G; p.L167R; 19:3151721-3151721	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.108G>T; p.K36N; 19:3136558-3136558	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.189G>T; p.R63R; 19:3148634-3148634	ovary	other; neoplasm	Substitution - coding silent
c.696G>A; p.L232L; 19:3155904-3155904	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.696G>A; p.L232L; 19:3155904-3155904	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation