lung cancer gene and literature database Home

Annotation category 5

Basic annotation
Ontology and pathways
Literature evidence
Curated literatures
Expression
Gene expression chart
Somatic mutation
COSMIC and TCGA mutations
Network
Gene interaction
ceRNA
Gene-related ceRNA

Gene information

Gene ID	274
Symbol	BIN1
Synonymous	AMPH2\|AMPHL\|SH3P9
Full name	bridging integrator 1
Gene description	amphiphysin II\|amphiphysin-like protein\|box dependant MYC interacting protein 1\|box-dependent myc-interacting protein 1\|myc box-dependent-interacting protein 1
Cytoband	2q14
Gene type	protein-coding
Synonymous	MIM:601248; HGNC:HGNC:1052; Ensembl:ENSG00000136717; HPRD:03150; Vega:OTTHUMG00000131465

COSMIC somatic mutation

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
c.1224C>A; p.P408P; 2:127053920-127053920	thyroid	other; neoplasm	Substitution - coding silent
c.1627G>T; p.A543S; 2:127050468-127050468	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.692G>A; p.W231*; 2:127063939-127063939	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.416G>T; p.R139L; 2:127069027-127069027	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1563C>T; p.F521F; 2:127050811-127050811	skin	malignant_melanoma	Substitution - coding silent
c.866C>A; p.A289E; 2:127059147-127059147	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.486T>C; p.T162T; 2:127068957-127068957	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.160C>T; p.Q54*; 2:127076631-127076631	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.486T>C; p.T162T; 2:127068957-127068957	thyroid	other; neoplasm	Substitution - coding silent
c.764A>G; p.E255G; 2:127063581-127063581	NS	NS	Substitution - Missense
c.486T>C; p.T162T; 2:127068957-127068957	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.403G>A; p.D135N; 2:127070003-127070003	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.403G>A; p.D135N; 2:127070003-127070003	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.403G>A; p.D135N; 2:127070003-127070003	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.527C>T; p.S176L; 2:127068248-127068248	urinary_tract; bladder	carcinoma	Substitution - Missense
c.527C>T; p.S176L; 2:127068248-127068248	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.905G>A; p.G302D; 2:127059108-127059108	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1747G>A; p.V583I; 2:127048561-127048561	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.273G>T; p.E91D; 2:127070595-127070595	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1781G>T; p.*594L; 2:127048527-127048527	liver	carcinoma; hepatocellular_carcinoma	Nonstop extension
c.687C>T; p.S229S; 2:127063944-127063944	skin	malignant_melanoma	Substitution - coding silent
c.739G>A; p.G247S; 2:127063606-127063606	skin	malignant_melanoma	Substitution - Missense
c.502G>A; p.E168K; 2:127068941-127068941	skin	malignant_melanoma	Substitution - Missense
c.576T>G; p.A192A; 2:127068199-127068199	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.698+10A>G; p.?; 2:127063923-127063923	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1353C>T; p.A451A; 2:127052273-127052273	pancreas	carcinoma	Substitution - coding silent
c.1401G>A; p.G467G; 2:127051214-127051214	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1745G>T; p.G582V; 2:127048563-127048563	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.669G>A; p.L223L; 2:127063962-127063962	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1621C>G; p.L541V; 2:127050474-127050474	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.570G>A; p.L190L; 2:127068205-127068205	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.796G>A; p.V266M; 2:127062176-127062176	pancreas	carcinoma	Substitution - Missense
c.796G>A; p.V266M; 2:127062176-127062176	pancreas	carcinoma	Substitution - Missense
c.957C>T; p.A319A; 2:127059056-127059056	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.957C>T; p.A319A; 2:127059056-127059056	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1264-10_1264-9insTGTGGGGGG; p.?; 2:127052371-127052372	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Unknown
c.957C>T; p.A319A; 2:127059056-127059056	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1359G>A; p.P453P; 2:127052267-127052267	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.277G>A; p.D93N; 2:127070591-127070591	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.866C>T; p.A289V; 2:127059147-127059147	lung	carcinoma; mucoepidermoid_carcinoma	Substitution - Missense
c.86T>G; p.V29G; 2:127076705-127076705	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.179G>A; p.R60Q; 2:127070803-127070803	central_nervous_system; brain	glioma	Substitution - Missense
c.1618C>T; p.Q540*; 2:127050477-127050477	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1618C>T; p.Q540*; 2:127050477-127050477	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.532C>A; p.L178I; 2:127068243-127068243	skin	malignant_melanoma	Substitution - Missense
c.532C>A; p.L178I; 2:127068243-127068243	skin	malignant_melanoma	Substitution - Missense
c.1596G>A; p.T532T; 2:127050499-127050499	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.278A>G; p.D93G; 2:127070590-127070590	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.177C>T; p.T59T; 2:127070805-127070805	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1539G>A; p.G513G; 2:127050835-127050835	pancreas	carcinoma	Substitution - coding silent
c.1539G>A; p.G513G; 2:127050835-127050835	pancreas	carcinoma	Substitution - coding silent
c.1625A>T; p.K542M; 2:127050470-127050470	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1625A>T; p.K542M; 2:127050470-127050470	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1633G>A; p.D545N; 2:127050462-127050462	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.604C>T; p.R202*; 2:127068171-127068171	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1362G>A; p.G454G; 2:127052264-127052264	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.337G>C; p.D113H; 2:127070069-127070069	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1474G>T; p.A492S; 2:127050900-127050900	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.546C>T; p.A182A; 2:127068229-127068229	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1549C>T; p.L517L; 2:127050825-127050825	skin	malignant_melanoma	Substitution - coding silent
c.1321A>G; p.T441A; 2:127052305-127052305	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.894G>A; p.S298S; 2:127059119-127059119	thyroid	other; neoplasm	Substitution - coding silent
c.894G>A; p.S298S; 2:127059119-127059119	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.33G>C; p.A11A; 2:127106911-127106911	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1653C>T; p.P551P; 2:127050442-127050442	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1309G>A; p.A437T; 2:127052317-127052317	stomach	carcinoma; mixed_intestinal_and_diffuse_adenocarcinoma-unclassifiable	Substitution - Missense
c.1461+1G>A; p.?; 2:127051153-127051153	stomach	carcinoma; adenocarcinoma	Unknown
c.864C>T; p.N288N; 2:127059149-127059149	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.85-4G>A; p.?; 2:127076710-127076710	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.671A>T; p.Q224L; 2:127063960-127063960	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1252G>A; p.D418N; 2:127053433-127053433	skin	malignant_melanoma	Substitution - Missense
c.698+8C>T; p.?; 2:127063925-127063925	skin; head_neck	malignant_melanoma; superficial_spreading	Unknown
c.1093A>T; p.T365S; 2:127057511-127057511	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.903T>G; p.D301E; 2:127059110-127059110	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.292G>T; p.D98Y; 2:127070576-127070576	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.684G>A; p.P228P; 2:127063947-127063947	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.285C>T; p.P95P; 2:127070583-127070583	skin	malignant_melanoma	Substitution - coding silent
c.470A>T; p.Y157F; 2:127068973-127068973	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.755T>A; p.F252Y; 2:127063590-127063590	skin	malignant_melanoma	Substitution - Missense
c.1573G>T; p.V525L; 2:127050522-127050522	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.175A>G; p.T59A; 2:127070807-127070807	pancreas	carcinoma	Substitution - Missense
c.652G>A; p.E218K; 2:127063979-127063979	skin	malignant_melanoma	Substitution - Missense
c.1652C>T; p.P551L; 2:127050443-127050443	skin	malignant_melanoma	Substitution - Missense
c.907T>C; p.S303P; 2:127059106-127059106	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.175_176AC>GA; p.T59D; 2:127070806-127070807	pancreas	carcinoma	Substitution - Missense
c.1007G>A; p.R336Q; 2:127057597-127057597	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.676_678delGAG; p.E226delE; 2:127063953-127063955	liver	carcinoma; hepatocellular_carcinoma	Deletion - In frame
c.1165A>T; p.S389C; 2:127053979-127053979	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.408C>A; p.I136I; 2:127069998-127069998	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.477C>T; p.S159S; 2:127068966-127068966	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1193T>C; p.L398P; 2:127053951-127053951	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.160C>A; p.Q54K; 2:127076631-127076631	adrenal_gland; adrenal_gland	adrenal_cortical_carcinoma; functioning	Substitution - Missense
c.589C>G; p.Q197E; 2:127068186-127068186	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1622T>G; p.L541R; 2:127050473-127050473	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1719G>T; p.Q573H; 2:127048589-127048589	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1630G>A; p.G544S; 2:127050465-127050465	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.908C>G; p.S303C; 2:127059105-127059105	breast	carcinoma	Substitution - Missense
c.1746C>T; p.G582G; 2:127048562-127048562	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.176C>A; p.T59N; 2:127070806-127070806	pancreas	carcinoma	Substitution - Missense
c.1609G>T; p.D537Y; 2:127050486-127050486	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.355delG; p.V119fs*6; 2:127070051-127070051	breast	carcinoma	Deletion - Frameshift
c.444G>A; p.V148V; 2:127068999-127068999	skin; upper_leg	malignant_melanoma	Substitution - coding silent
c.843C>G; p.V281V; 2:127062129-127062129	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.657G>A; p.M219I; 2:127063974-127063974	prostate	carcinoma	Substitution - Missense
c.1227G>A; p.T409T; 2:127053917-127053917	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.433C>G; p.R145G; 2:127069010-127069010	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.657G>A; p.M219I; 2:127063974-127063974	prostate	carcinoma	Substitution - Missense
c.657G>A; p.M219I; 2:127063974-127063974	prostate	carcinoma	Substitution - Missense
c.1227G>A; p.T409T; 2:127053917-127053917	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1419A>G; p.G473G; 2:127051196-127051196	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1194C>A; p.L398L; 2:127053950-127053950	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.1194C>A; p.L398L; 2:127053950-127053950	lung	carcinoma; non_small_cell_carcinoma	Substitution - coding silent
c.494delA; p.K165fs*31; 2:127068949-127068949	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.193C>T; p.L65F; 2:127070789-127070789	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.701G>A; p.R234H; 2:127063644-127063644	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1707C>T; p.S569S; 2:127048601-127048601	breast	carcinoma	Substitution - coding silent
c.688C>T; p.L230L; 2:127063943-127063943	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.888C>T; p.S296S; 2:127059125-127059125	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - coding silent
c.85-1G>A; p.?; 2:127076707-127076707	urinary_tract; bladder	carcinoma	Unknown
c.1241C>G; p.S414*; 2:127053444-127053444	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1477G>A; p.V493I; 2:127050897-127050897	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1292C>T; p.P431L; 2:127052334-127052334	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.550delC; p.Q184fs*12; 2:127068225-127068225	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1618C>A; p.Q540K; 2:127050477-127050477	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.260A>T; p.Q87L; 2:127070608-127070608	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.187A>G; p.K63E; 2:127070795-127070795	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.402C>T; p.P134P; 2:127070004-127070004	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.262G>T; p.E88*; 2:127070606-127070606	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1696G>A; p.V566M; 2:127048612-127048612	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.714C>T; p.Y238Y; 2:127063631-127063631	thyroid	other; neoplasm	Substitution - coding silent
c.1297G>A; p.G433R; 2:127052329-127052329	skin	malignant_melanoma	Substitution - Missense
c.79_81delGAG; p.E27delE; 2:127106863-127106865	endometrium	carcinoma; endometrioid_carcinoma	Deletion - In frame
c.1281C>T; p.A427A; 2:127052345-127052345	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1622T>A; p.L541H; 2:127050473-127050473	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.233C>T; p.A78V; 2:127070635-127070635	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense

Annotation category 5

Basic annotation

Literature evidence

Expression

Somatic mutation

Network

ceRNA

Gene information

COSMIC somatic mutation